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    v1.0.31
    OpenPayerBilling CodesTemporary National Codes (Non-Medicare)HCPCS hcpcs-s2054-multivisceral-organ-transplantation
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    HCPCS S2054: Transplantation of Multivisceral Organs

    HCPCS Level II code S2054 describes transplantation of multivisceral organs, a complex surgical procedure that involves removal and replacement of multiple abdominal organs; the service is a multiorgan transplant surgery typically performed in an inpatient hospital or transplant center operating room setting.

    For related coverage guidance, see recent payer policy updates: Non-Emergency Facility to Facility Transfers, Non-Emergency Facility to Facility Transfers, Medical Necessity Guidelines Non-Emergency Transportation.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient undergoing S2054 (transplantation of multivisceral organs) is an adult with end-stage, irreversible failure of multiple abdominal organs—commonly liver plus stomach, pancreas, small intestine, and sometimes kidney—often after chronic intestinal failure, short bowel syndrome, or extensive splanchnic vascular thrombosis. Presentation includes progressive malnutrition, dependence on total parenteral nutrition with associated liver disease, recurrent catheter-related sepsis, or multiorgan failure from congenital or acquired disorders.

    The clinical workflow begins with multidisciplinary evaluation by transplant surgery, hepatology, gastroenterology, transplant infectious disease, nutrition, and psychiatry. Preoperative workup includes imaging (CT/MRI angiography), cardiopulmonary assessment, infectious disease screening, nutritional and immunologic evaluation, and optimization of comorbidities. Organ allocation and donor selection are coordinated through the organ procurement organization. The operative encounter involves en bloc explantation of native viscera and implantation of donor multivisceral grafts in a specialized transplant operating room with experienced surgical, anesthesia, and perfusion teams. Postoperative care occurs in a tertiary ICU with intensive immunosuppression management, infectious prophylaxis, surveillance endoscopy of the graft, and long-term outpatient transplant follow-up for rejection surveillance and functional recovery.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    00790Anesthesia for intrathoracic proceduresMay be used if thoracic procedures are needed during multivisceral transplant or for anesthesia reporting when thoracic exposure occurs
    00562Anesthesia for procedures on liver, pancreas, spleenCommon anesthesia codes used for major abdominal organ transplantation support during multivisceral operations
    44120Enterectomy, resection of small intestine; single resection and anastomosisMay be performed as part of explant or reconstruction during multivisceral transplant
    47135Hepatectomy, partial lobectomyPortions of native liver resection or donor hepatectomy steps relate to the transplant operative course
    44160Intestinal anastomosis (resection with anastomosis)Used for reconstruction of intestinal continuity during implantation of intestinal grafts
    33944Extracorporeal circulation auxiliary procedures (if applicable)Applicable when cardiopulmonary support or bypass is used intraoperatively

    Related Modifiers

    12 rows

    ModifierDescriptionWhen to Use
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    73Modifier 73 indicates a facility-level outpatient hospital or ASC procedure that was discontinued after the patient was prepared and taken to the procedure/operating room but before any anesthesia…- When to use: Apply CPT modifier 73 on the FACILITY (outpatient hospital or ASC) claim when the patient has been fully prepared and physically taken into the procedure/operating room but the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…

    Showing 1–10 of 12

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207L00000X
    207RH0000X
    207P00000X
    2080P0207X
    282NR1301X
    207XX0004X
    226300000X
    2080P0204X

    Related Payer Policy Updates

    Specialty: Emergency & Medical Transportation1 / 3

    10 rows

    PolicyPayerEffective Date
    Non-Emergency Facility to Facility TransfersCareSource Georgia2026-11-01
    Non-Emergency Facility to Facility Transferscaresourcegeorgia2026-11-01
    Medical Necessity Guidelines Non-Emergency TransportationMass General Brigham Health Plan2026-11-01
    Non-Emergent Transportation Medical PolicyHealth-New-England2026-11-01
    Non-Emergency Facility to Facility Transfershap_caresource_mi_coordinated_health2026-11-01
    Ambulance and Medical Transport Services (Ground, Air and Water) Corporate Medical Policybcbsvermont2026-10-01
    Emergency Air/Water Ambulance Services Medical GuidelineWPS Health Insurance2026-10-01
    Non-Emergent Ambulance ServicesConnectiCare2026-09-11
    Fixed Wing Air Ambulance TransportCigna2026-08-15
    Air AmbulanceAmbetter Georgia2026-08-01

    Related Codes

    HCPCS-LEVEL-II-S2152-SOLID-ORGAN-TRANSPLANTATION-GLOBAL-CARE

    HCPCS Level II S2152: Solid Organ Procurement and Transplantation

    HCPCS-LEVEL-II-S2266-INDUCED-ABORTION-29-TO-31-WEEKS

    HCPCS Level II S2266: Induced Abortion, 29 to 31 Weeks

    HCPCS-LEVEL-II-S3630-EOSINOPHIL-COUNT-BLOOD-DIRECT

    HCPCS Level II S3630: Eosinophil Count, Blood, Direct

    HCPCS-LEVEL-II-S4017-INCOMPLETE-ART-CYCLE-CANCELLED-PRIOR-TO-STIMULATION

    HCPCS Level II S4017: Incomplete Cycle — Cancelled Prior to Stimulation

    HCPCS-LEVEL-II-S8055-ULTRASOUND-GUIDANCE-MULTIFETAL-REDUCTION-TC

    HCPCS Level II S8055: Ultrasound Guidance for Multifetal Pregnancy Reduction

    HCPCS-LEVEL-II-S8940-EQUESTRIAN-HIPPOTHERAPY-PER-SESSION

    HCPCS Level II S8940: Equestrian/Hippotherapy, Per Session

    HCPCS-LEVEL-II-S9024-PARANASAL-SINUS-ULTRASOUND

    HCPCS Level II S9024: Paranasal Sinus Ultrasound

    HCPCS-LEVEL-II-S9366-HOME-TPN-1-2L-PER-DAY-HOME-INFUSION

    HCPCS Level II S9366: Home Infusion TPN, 1–2 L/day

    HCPCS-LEVEL-II-S9446-GROUP-PATIENT-EDUCATION-NON-PHYSICIAN

    HCPCS S9446: Patient Education, Non-Physician Provider, Group, Per Session

    HCPCS-LEVEL-II-S9451-EXERCISE-CLASS-NON-PHYSICIAN-SESSION

    HCPCS S9451: Exercise Classes, Non-Physician Provider, Per Session

    Showing 1–10 of 532

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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