Summary & Overview

HCPCS Level II S0171: Injection, Bumetanide 0.5 mg

HCPCS Level II code S0171 designates an injectable supply of bumetanide at a 0.5 mg unit. Bumetanide is a loop diuretic used to manage fluid overload in a variety of acute and chronic conditions; an HCPCS Level II supply code like S0171 is important for accurate billing of administered injectable drug units outside of standard pharmacy billing pathways. Nationwide, consistent use of this code affects facility and professional billing, drug utilization tracking, and payment adjudication for outpatient injectable therapies.

Key payers discussed include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise outline of clinical context for injectable bumetanide, typical sites of service where S0171 applies, and the role of this code in service-line billing. The publication summarizes available benchmarks and payment considerations where applicable and highlights common operational issues around coding injectable medications for outpatient administration. Data not available in the input for detailed payer-specific rates, associated taxonomies, ICD-10 pairings, and related codes.

AetnaBlue Cross Blue ShieldCigna HealthUnitedHealthcareMedicareS0171HCPCS Level IIinjectable diureticbumetanidedrug administrationoutpatientinfusionbillingdrug code

Billing Code Overview

HCPCS Level II code S0171 represents Injection, bumetanide, 0.5 mg. This code covers administration of the loop diuretic bumetanide in a 0.5 mg unit of drug for use in a clinical setting.

Service type: Drug administration (injectable diuretic)
Typical site of service: Ambulatory clinic, physician office, infusion center, or other outpatient settings where injectable medications are provided.

If additional billing details such as modifiers, associated taxonomies, or ICD-10 diagnoses are required, Data not available in the input.

Clinical & Coding Specifications

Clinical Context

A typical patient is an adult with acute decompensated heart failure or symptomatic fluid overload who requires a rapid-acting loop diuretic in the outpatient infusion center, emergency department, or inpatient ward. The clinician orders S0171 for administration of bumetanide 0.5 mg via intramuscular or intravenous injection when oral diuretics are ineffective, the patient is NPO, has poor oral absorption, or needs prompt diuresis. The nursing workflow includes verification of indication and allergies, confirmation of recent weight and input/output, preparation of medication per facility protocol, venous access assessment (peripheral IV or existing central access), administration of the 0.5 mg dose, monitoring of vital signs, urine output, and electrolytes, and documentation of dose, route, time, lot number, and patient response. Typical sites of service are outpatient infusion centers, hospital inpatient units, emergency departments, and skilled nursing facilities. Clinical monitoring focuses on blood pressure, renal function, and serum electrolytes within 24 hours after administration.

Coding Specifications

Modifier	Description	When to Use
`22`	Increased procedural services	Use when preparation or administration required substantially greater effort than usual (e.g., complex vascular access or prolonged monitoring).
`23`	Unusual anesthesia	Use when general anesthesia or a deep sedation unrelated to the injection is provided during administration.
`52`	Reduced services	Use when the injection/service is partially reduced or not completed as planned.
`53`	Discontinued procedure	Use when the injection was started but discontinued due to patient instability.
`54`	Surgical care only	Rare for medication injection; use if only surgical portion applies and unrelated to this injection.
`55`	Postoperative management only	Use when only postoperative management is billed separate from the drug administration.
`56`	Preoperative management only	Use when only preoperative management is billed separate from the drug administration.
`62`	Two surgeons	Use when two qualified surgeons are required and both bill separately; uncommon for medication injection.
`78`	Unplanned return to operating/procedure room	Use if patient requires return for a complication directly related to the injection procedure.
`AS`	Physician assistant, nurse practitioner, or clinical nurse specialist services for assistant at surgery	Use when an advanced practitioner assists in a procedure associated with the injection.
`CO`	Worker’s Compensation or public payer jurisdictional reporting	Use to indicate specific payer reporting requirements where applicable.
`CQ`	Service furnished by a physician or other qualified health care professional incident to a CRNA	Use when service is related to anesthesia care model involving CRNA.
`QK`	Medical direction of two, three, or four concurrent anesthesia procedures involving qualified individuals	Use in anesthesia billing contexts when directing concurrent cases that include this injection.

Taxonomy Code	Specialty	Notes
`208D00000X`	Cardiology	Cardiology clinics and inpatient cardiology teams commonly order IV bumetanide for acute decompensated heart failure.
`283Q00000X`	Nephrology	Nephrologists manage volume overload in patients with renal impairment and may direct IV diuretic therapy.
`163W00000X`	Emergency Medicine	Emergency clinicians administer IV bumetanide for acute pulmonary edema and symptomatic volume overload.
`3336C0002X`	Hospitalist/Internal Medicine	Hospitalists frequently order and document inpatient IV diuretic administration and monitoring.
`363L00000X`	Family Medicine	Family medicine physicians in urgent care or outpatient infusion settings may administer IV bumetanide for symptomatic patients.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`I50.33`	Acute on chronic systolic (congestive) heart failure	Acute decompensation with volume overload often requires IV loop diuretics such as bumetanide.
`I50.23`	Acute on chronic diastolic (congestive) heart failure	Volume overload in diastolic failure may require rapid IV diuresis.
`I50.9`	Heart failure, unspecified	General coding for heart failure episodes where IV diuretics are indicated.
`R60.0`	Localized edema	Symptomatic edema not otherwise specified may be treated with parenteral diuretics when severe.
`R09.02`	Hypoxemia	Associated with pulmonary edema from fluid overload; IV diuretics aid decongestion.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96372`	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular	Commonly billed for single IM administration of a medication like bumetanide when documentation supports IM route.
`96365`	Intravenous infusion, for therapy, prophylaxis, or diagnosis; initial, up to 1 hour	Used when bumetanide is administered as part of an IV infusion encounter requiring monitoring and concurrent IV infusion services.
`96374`	Intravenous push, single or initial substance/drug	Billed when bumetanide is given as an IV push (bolus) and separate from infusion services.
`36415`	Collection of venous blood by venipuncture	Often performed before or after administration for serum electrolytes, BUN, creatinine, and drug monitoring.
`99070`	Supplies and materials (e.g., drugs, administrative supplies) provided by the physician over and above those usually included	Used for drug preparation supplies or single-use administration kits associated with injection billing.