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    v1.0.30
    OpenPayerBilling CodesPathology and Laboratory ServicesHCPCS hcpcs-p9012-cryoprecipitate-each-unit
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    HCPCS Level II P9012: Cryoprecipitate, Each Unit

    HCPCS Level II code P9012 describes a single unit of cryoprecipitate, a plasma-derived blood product rich in fibrinogen and clotting factors used to treat bleeding disorders; the service is the provision/administration of one unit of cryoprecipitate, typically delivered in hospital settings or other acute care sites where blood products are transfused.

    For related coverage guidance, see recent payer policy updates: Hematology - Adzynma, Tumor Treating Fields for Pancreatic Cancer, Axicabtagene ciloleucel (Yescarta®) coverage.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient scenario involves an adult inpatient with active bleeding or at high risk for bleeding due to hypofibrinogenemia, disseminated intravascular coagulation (DIC), massive transfusion, or congenital fibrinogen deficiency who requires transfusion support. Cryoprecipitate (P9012, cryoprecipitate, each unit) is prepared by thawing frozen plasma and pooling the cold-insoluble precipitate rich in fibrinogen, factor VIII, von Willebrand factor, and factor XIII. Clinical workflow: the ordering clinician documents an indication (for example, fibrinogen <100 mg/dL with bleeding), the transfusion service verifies crossmatch and product availability, the blood bank issues thawed cryoprecipitate units, bedside nursing performs patient identification and administers the product, and transfusion monitoring and post-transfusion fibrinogen levels are obtained as indicated. Typical sites of service include the inpatient hospital ward, intensive care unit, emergency department, and operating room during perioperative or trauma care. Patient monitoring includes vital signs, signs of transfusion reaction, and laboratory assessment of coagulation parameters after administration.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    36430Transfusion, blood or blood components, percutaneous, includes all infusions and concurrent monitoringUsed for administration of blood products including cryoprecipitate when billed as a transfusion administration service
    36440Transfusion, blood or blood components; each additional unit, peripheral venous catheterUsed when additional units are administered during the same session and may support billing for multiple-unit administration efforts
    36415Collection of venous blood by venipuncturePerformed before transfusion for crossmatch, type and screen, and laboratory monitoring
    85610Prothrombin timeCoagulation testing often ordered before/after cryoprecipitate to assess bleeding risk and response
    85385Fibrinogen; Clauss methodDirect measurement of fibrinogen level used to determine indication for and response to cryoprecipitate transfusion

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RH0000X
    208800000X
    207L00000X
    385HR2065X
    163WH0500X
    103TE1000X
    261QC1800X
    207WX0109X

    Related ICD-10-CM Codes

    21 rows

    ICD-10-CM CodeDescription
    D62Acute posthemorrhagic anemia
    D65Disseminated intravascular coagulation [defibrination syndrome]
    D66Hereditary factor VIII deficiency
    D67Hereditary factor IX deficiency
    D68.4Acquired coagulation factor deficiency
    D69.3Immune thrombocytopenic purpura
    D69.6Thrombocytopenia, unspecified
    I50.9Heart failure, unspecified
    I81Portal vein thrombosis
    I82.409Acute embolism and thrombosis of unspecified deep veins of unspecified lower extremity

    Showing 1–10 of 21

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 4

    10 rows

    PolicyPayerEffective Date
    Hematology - AdzynmaCigna2026-10-15
    Tumor Treating Fields for Pancreatic Cancerselect_health2026-10-01
    Axicabtagene ciloleucel (Yescarta®) coverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Kentucky Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Kansas Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Idaho Only)UnitedHealthcare2026-10-01
    Brexucabtagene autoleucel (Tecartus) CoverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Pennsylvania Only)UnitedHealthcare2026-10-01
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Factor VIII ProductsCigna2026-09-15

    Related Codes

    HCPCS-LEVEL-II-P2029-CONGO-RED-BLOOD-TEST

    HCPCS P2029: Congo red, blood

    HCPCS-P2028-CEPHALIN-FLOCCULATION-BLOOD

    HCPCS Level II P2028: Cephalin Flocculation, Blood

    HCPCS-P2031-HAIR-ANALYSIS-EXCLUDING-ARSENIC

    HCPCS P2031: Hair Analysis (Excluding Arsenic)

    HCPCS-P2033-THYMOL-TURBIDITY-BLOOD-LAB-TEST

    HCPCS P2033: Thymol Turbidity, Blood

    HCPCS-P2038-MUCOPROTEIN-BLOOD-SEROMUCOID-LAB-TEST

    HCPCS Level II P2038: Mucoprotein (Seromucoid) Blood Test

    HCPCS-P3000-SCREENING-PAP-SMEAR-TECHNICIAN-SUPERVISED

    HCPCS Level II P3000: Screening Papanicolaou Smear by Technician

    HCPCS-P3001-SCREENING-PAP-SMEAR-CERVICAL-VAGINAL

    HCPCS Level II P3001: Screening Papanicolaou Smear, Up to Three Smears

    HCPCS-P7001-QUANTITATIVE-URINE-BACTERIAL-CULTURE-SENSITIVITY

    HCPCS P7001: Urine Bacterial Culture, Quantitative with Sensitivity

    HCPCS-P9010-WHOLE-BLOOD-TRANSFUSION-PER-UNIT

    HCPCS Level II P9010: Blood (whole) for Transfusion, per Unit

    HCPCS-P9011-BLOOD-SPLIT-UNIT

    HCPCS Level II P9011: Blood, Split Unit

    Showing 1–10 of 58

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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