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    v1.0.30
    OpenPayerBilling CodesPathology and Laboratory ServicesHCPCS hcpcs-p2028-cephalin-flocculation-blood
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    HCPCS Level II P2028: Cephalin Flocculation, Blood

    HCPCS Level II code P2028 describes cephalin flocculation testing on blood, a laboratory procedure that assesses blood plasma reactivity by measuring flocculation of cephalin; service type is laboratory diagnostic test, typically performed in clinical laboratory or hospital laboratory settings.

    For related coverage guidance, see recent payer policy updates: Hematology - Adzynma, Tumor Treating Fields for Pancreatic Cancer, Axicabtagene ciloleucel (Yescarta®) coverage.

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    Clinical & Coding Specifications

    Clinical Context

    A patient presents to the outpatient hematology or laboratory service for evaluation of a suspected coagulation disorder or monitoring of an existing bleeding disorder. Typical indications include unexplained bruising, mucosal bleeding, prolonged bleeding after a procedure, family history of bleeding diathesis, or abnormal screening coagulation tests. The clinician orders specialized platelet function and coagulation assays; one such test is the cephalin flocculation (also known as the kaolin-cephalin flocculation test) performed on a blood specimen.

    The clinical workflow: the patient has blood drawn in the phlebotomy area of an ambulatory clinic, hospital outpatient lab, or inpatient ward. The sample is labeled and transported to the clinical laboratory. A medical laboratory technologist performs the cephalin flocculation assay, documents results in the laboratory information system, and the hematologist or ordering clinician reviews results and integrates them into the diagnostic workup or monitoring plan. Typical sites of service include hospital outpatient laboratory, independent clinical laboratory, and inpatient hospital laboratory.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    36415Collection of venous blood by venipuncturePerformed immediately before the cephalin flocculation test to obtain the specimen.
    85025Blood count; complete (CBC) automated and automated differential WBC countCommonly ordered alongside coagulation and platelet function testing to assess platelet count and morphology.
    85610Prothrombin time (PT)Often performed in the same coagulation panel and provides complementary information about clotting cascade function.
    85730Thrombin time (TT)May be ordered with cephalin flocculation when assessing fibrinogen function or suspected heparin effect.
    86040Immunohematology testing for platelet antibodies (when indicated)Performed when immune-mediated platelet dysfunction is suspected after abnormal platelet function assays.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RH0000X
    207L00000X
    363LF0000X
    2080P0207X
    320800000X
    2088P0231X
    376J00000X
    2084N0402X

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    A41.9Sepsis, unspecified organism
    B34.9Viral infection, unspecified
    B37.7Candidal sepsis
    D65Disseminated intravascular coagulation [defibrination syndrome]
    D68.4Acquired coagulation factor deficiency
    D68.9Coagulation defect, unspecified
    D69.3Immune thrombocytopenic purpura
    D69.41Evans syndrome
    D69.42Congenital and hereditary thrombocytopenia purpura
    D69.59Other secondary thrombocytopenia

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 4

    10 rows

    PolicyPayerEffective Date
    Hematology - AdzynmaCigna2026-10-15
    Tumor Treating Fields for Pancreatic Cancerselect_health2026-10-01
    Axicabtagene ciloleucel (Yescarta®) coverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Kentucky Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Kansas Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Idaho Only)UnitedHealthcare2026-10-01
    Brexucabtagene autoleucel (Tecartus) CoverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Pennsylvania Only)UnitedHealthcare2026-10-01
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Factor VIII ProductsCigna2026-09-15

    Related Codes

    HCPCS-LEVEL-II-P2029-CONGO-RED-BLOOD-TEST

    HCPCS P2029: Congo red, blood

    HCPCS-P2031-HAIR-ANALYSIS-EXCLUDING-ARSENIC

    HCPCS P2031: Hair Analysis (Excluding Arsenic)

    HCPCS-P2033-THYMOL-TURBIDITY-BLOOD-LAB-TEST

    HCPCS P2033: Thymol Turbidity, Blood

    HCPCS-P2038-MUCOPROTEIN-BLOOD-SEROMUCOID-LAB-TEST

    HCPCS Level II P2038: Mucoprotein (Seromucoid) Blood Test

    HCPCS-P3000-SCREENING-PAP-SMEAR-TECHNICIAN-SUPERVISED

    HCPCS Level II P3000: Screening Papanicolaou Smear by Technician

    HCPCS-P3001-SCREENING-PAP-SMEAR-CERVICAL-VAGINAL

    HCPCS Level II P3001: Screening Papanicolaou Smear, Up to Three Smears

    HCPCS-P7001-QUANTITATIVE-URINE-BACTERIAL-CULTURE-SENSITIVITY

    HCPCS P7001: Urine Bacterial Culture, Quantitative with Sensitivity

    HCPCS-P9010-WHOLE-BLOOD-TRANSFUSION-PER-UNIT

    HCPCS Level II P9010: Blood (whole) for Transfusion, per Unit

    HCPCS-P9011-BLOOD-SPLIT-UNIT

    HCPCS Level II P9011: Blood, Split Unit

    HCPCS-P9012-CRYOPRECIPITATE-EACH-UNIT

    HCPCS Level II P9012: Cryoprecipitate, Each Unit

    Showing 1–10 of 58

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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