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    OpenPayerBilling CodesPathology and Laboratory ServicesHCPCS hcpcs-level-ii-p2029-congo-red-blood-test
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    HCPCS P2029: Congo red, blood

    HCPCS Level II code P2029 represents a laboratory test for Congo red staining performed on blood specimens, used to detect amyloid or other abnormal protein deposits; this is a pathology/chemistry diagnostic service typically billed for clinical laboratory settings such as hospital labs, reference laboratories, or outpatient laboratory collection sites.

    For related coverage guidance, see recent payer policy updates: Hematology - Adzynma, Tumor Treating Fields for Pancreatic Cancer, Axicabtagene ciloleucel (Yescarta®) coverage.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult referred from primary care or hematology for evaluation of suspected systemic amyloidosis after presenting with unexplained nephrotic-range proteinuria, restrictive cardiomyopathy, peripheral neuropathy, or abnormal light-chain studies. A phlebotomy appointment is scheduled in an outpatient laboratory or hospital lab. A trained phlebotomist or laboratory technologist collects a blood specimen in the appropriate tube, labels it per facility policy, and sends it to the clinical laboratory. The laboratory performs Congo red staining on a blood-derived specimen (usually to detect circulating amyloid or for research/confirmatory testing) or processes the sample for further confirmatory testing such as immunofixation, serum free light chains, or mass spectrometry. Results are reviewed by the ordering clinician (e.g., hematologist, nephrologist, cardiologist) and integrated with clinical evaluation, tissue biopsy results, and other laboratory studies to guide diagnosis and management.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    36415Collection of venous blood by venipunctureCommonly performed immediately prior to ordering the Congo red blood test to obtain the specimen.
    80305Drug screen, presumptive (not directly related)Data not available in the input.
    83880Immunoassay for analyte other than infectious agent (first step)Often used for adjunctive serum free light chain or immunoassay testing when evaluating suspected amyloidosis.
    86301Immunoassay for tumor antigens (not directly related)Data not available in the input.
    88342Immunohistochemistry or special stains on surgical pathology specimens (special stain)Used for Congo red staining in tissue biopsy workflows; related when tissue biopsy is performed to confirm amyloid.
    84999Unlisted chemistry procedureUsed rarely when a specific laboratory test does not have a direct CPT equivalent; may be used for novel or specialized amyloid assays.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    2080P0206X
    2084P0800X
    207RH0000X
    207RR0500X
    207RC0000X
    2251P0200X
    261QP0905X
    125J00000X

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 4

    10 rows

    PolicyPayerEffective Date
    Hematology - AdzynmaCigna2026-10-15
    Tumor Treating Fields for Pancreatic Cancerselect_health2026-10-01
    Axicabtagene ciloleucel (Yescarta®) coverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Kentucky Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Kansas Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Idaho Only)UnitedHealthcare2026-10-01
    Brexucabtagene autoleucel (Tecartus) CoverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Pennsylvania Only)UnitedHealthcare2026-10-01
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Factor VIII ProductsCigna2026-09-15

    Related Codes

    HCPCS-P2028-CEPHALIN-FLOCCULATION-BLOOD

    HCPCS Level II P2028: Cephalin Flocculation, Blood

    HCPCS-P2031-HAIR-ANALYSIS-EXCLUDING-ARSENIC

    HCPCS P2031: Hair Analysis (Excluding Arsenic)

    HCPCS-P2033-THYMOL-TURBIDITY-BLOOD-LAB-TEST

    HCPCS P2033: Thymol Turbidity, Blood

    HCPCS-P2038-MUCOPROTEIN-BLOOD-SEROMUCOID-LAB-TEST

    HCPCS Level II P2038: Mucoprotein (Seromucoid) Blood Test

    HCPCS-P3000-SCREENING-PAP-SMEAR-TECHNICIAN-SUPERVISED

    HCPCS Level II P3000: Screening Papanicolaou Smear by Technician

    HCPCS-P3001-SCREENING-PAP-SMEAR-CERVICAL-VAGINAL

    HCPCS Level II P3001: Screening Papanicolaou Smear, Up to Three Smears

    HCPCS-P7001-QUANTITATIVE-URINE-BACTERIAL-CULTURE-SENSITIVITY

    HCPCS P7001: Urine Bacterial Culture, Quantitative with Sensitivity

    HCPCS-P9010-WHOLE-BLOOD-TRANSFUSION-PER-UNIT

    HCPCS Level II P9010: Blood (whole) for Transfusion, per Unit

    HCPCS-P9011-BLOOD-SPLIT-UNIT

    HCPCS Level II P9011: Blood, Split Unit

    HCPCS-P9012-CRYOPRECIPITATE-EACH-UNIT

    HCPCS Level II P9012: Cryoprecipitate, Each Unit

    Showing 1–10 of 58

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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