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    v1.0.30
    OpenPayerBilling CodesMatrix for Wound Management (Placental, Equine, Synthetic)HCPCS hcpcs-a2010-apis-per-square-centimeter-topical-biologic-add-on
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    HCPCS Level II A2010: Apis Topical Product Per Square Centimeter

    Medicare pays $133 on average nationally for this procedure.

    HCPCS Level II code A2010 describes billing for Apis topical product measured per square centimeter to be reported as an add-on, listed separately in addition to the primary procedure; this code represents a topical dermatologic/therapeutic application typically used in ambulatory clinic or outpatient procedural settings where surface-area–based topical agents are applied and billed separately from the primary service.

    For related coverage guidance, see recent payer policy updates: Breast Reduction (Mammoplasty) Surgery, Rhinoplasty Medical Necessity and Site of Service, Surgical Treatments for Lymphedema.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient scenario involves a dermatologist treating a patient with a localized area of cutaneous inflammation or lesion requiring topical apitoxin (bee venom) application as an adjunct to a primary procedure. The billing code A2010 represents apis (bee venom) billed per square centimeter as an add-on supply when used in conjunction with a primary procedure (for example, wound care, dermatologic debridement, or topical immunotherapy).

    In workflow: the patient presents to an outpatient dermatology or wound care clinic. The primary procedure (e.g., lesion debridement, excision, or advanced wound dressing application) is performed first. Clinical staff measure the area in square centimeters to determine the quantity of A2010 required. The apitoxin preparation is applied topically to the wound or lesion site per protocol. Documentation includes the primary procedure code and notes the square centimeters treated, the lot/batch of the apitoxin product, informed consent for topical biologic use, and any immediate clinical response. Billing includes the primary procedure CPT and the add-on code A2010 reported per square centimeter with appropriate modifiers as indicated by payer rules and clinical circumstances.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    11042Debridement, subcutaneous tissue (first 20 sq cm or less)May precede A2010 when apis is applied to a debrided wound bed as an adjunct topical biologic.
    11044Debridement, muscle and/or fascia (first 20 sq cm or less)Applicable when deeper debridement is performed prior to topical apis application.
    12001Simple repair of superficial wounds (up to 2.5 cm)May be part of the procedural course when apis is applied to surgically treated skin lesions.
    15002Burn debridement and/or excision (first 10 sq cm)Used when burn care is required and topical apis is applied to treated burn wound areas.
    97602Debridement, non-surgical (e.g., selective debridement)May be performed before topical apis application in wound clinic settings.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207Q00000X
    207P00000X
    208000000X
    207U00000X
    207RX0202X
    261QR0208X
    111NI0900X
    3336N0007X

    Related Payer Policy Updates

    Specialty: Plastic/Reconstructive Surgery1 / 3

    10 rows

    PolicyPayerEffective Date
    Breast Reduction (Mammoplasty) SurgeryKaiser Permanente2027-02-01
    Rhinoplasty Medical Necessity and Site of ServicePremera Bluecross2026-10-14
    Surgical Treatments for LymphedemaProvidence Health Plan2026-10-01
    Surgical Treatment of Lipedema and LymphedemaPremera Bluecross2026-10-01
    Breast Reduction Surgery (for North Carolina Only)UnitedHealthcare2026-10-01
    Cosmetic, Reconstructive, or Plastic SurgeryUnitedHealthcare2026-10-01
    Surgical Treatments for LymphedemaProvidence Health Plan2026-10-01
    Reduction Mammoplasty (Breast Reduction Surgery) for Symptomatic MacromastiaWPS Health Insurance2026-10-01
    Reduction MammoplastyModa Health2026-10-01
    Treatment for Lipedema (Lipectomy/Liposuction)Moda Health2026-10-01

    Related Codes

    HCPCS-A2001-INNOVAMATRIX-PER-SQ-CM

    HCPCS Level II A2001: Innovamatrix ac, per square centimeter (add-on)

    HCPCS-A2002-MIRRAGEN-ADVANCED-WOUND-MATRIX-PER-CM2

    HCPCS Level II A2002: Mirragen Advanced Wound Matrix, per sq cm

    HCPCS-A2004-XCELLISTEM-1MG-SPECIALTY-BIOLOGIC-SUPPLY

    HCPCS A2004: Xcellistem, 1 mg

    HCPCS-A2005-MICROLYTE-MATRIX-WOUND-BIOMATERIAL-PER-CM2

    HCPCS Level II A2005: Microlyte Matrix, Per Square Centimeter

    HCPCS-A2006-NOVOSORB-DERMAL-MATRIX-PER-CM

    HCPCS A2006: Novosorb Synpath Dermal Matrix, per cm2

    HCPCS-A2007-RESTRATA-PER-SQ-CM-TOPICAL-WOUND-MATERIAL

    HCPCS Level II A2007: Restrata, per Square Centimeter (Add-on)

    HCPCS-A2008-THERAGENESIS-PER-SQUARE-CENTIMETER-ADD-ON

    HCPCS Level II A2008: Theragenesis, Per Square Centimeter

    HCPCS-A2009-SYMPHONY-PER-SQUARE-CENTIMETER-ADD-ON

    HCPCS Level II A2009: Symphony, per Square Centimeter (Add-on)

    HCPCS-A2011-SUPRA-SDRM-PER-SQ-CM-ADD-ON

    HCPCS Level II A2011: Suprasdrm per Square Centimeter (Add-on)

    HCPCS-A2012-SUPRATHEL-PER-SQUARE-CENTIMETER

    HCPCS A2012: Suprathel Skin Substitute, Per cm2

    Showing 1–10 of 43

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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