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    OpenPayerBilling CodesMatrix for Wound Management (Placental, Equine, Synthetic)HCPCS hcpcs-a2006-novosorb-dermal-matrix-per-cm
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    HCPCS A2006: Novosorb Synpath Dermal Matrix, per cm2

    Medicare pays $133 on average nationally for this procedure.

    HCPCS Level II code A2006 describes billing for Novosorb Synpath dermal matrix billed per square centimeter as an add-on product used in surgical reconstruction or wound repair; the service is a dermal matrix graft/implant and is typically provided in operative or outpatient surgical settings such as ambulatory surgery centers or hospital operating rooms.

    For related coverage guidance, see recent payer policy updates: Breast Reduction (Mammoplasty) Surgery, Rhinoplasty Medical Necessity and Site of Service, Surgical Treatments for Lymphedema.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 62-year-old with a chronic full-thickness lower extremity wound after failed conservative care and debridement. The wound demonstrates inadequate granulation and exposed subcutaneous tissue; the surgical team elects to apply a NovoSorb Biodegradable Temporizing Matrix (NovoSorb SynPath dermal matrix) as part of a staged reconstructive wound management strategy. The procedure is performed in an operating room or procedure suite under local anesthesia with sedation or general anesthesia depending on wound extent. The clinical workflow includes preoperative wound assessment and debridement, measurement of the defect in square centimeters, preparation and placement of the dermal matrix cut to size, securement to the wound bed, and documentation of square centimeters of product used for billing with A2006 as an add-on billing line to the primary closure, grafting, or wound repair procedure. Postoperative care includes dressing application, instruction for immobilization or offloading, and scheduled follow-up for assessment of integration and planning for potential skin grafting once neodermis forms.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    11042Debridement, muscle and/or fascia (first 20 sq cm or less)Often performed immediately before placement of a dermal matrix to prepare a viable wound bed.
    15271Placement of biologic or synthetic dermal substitute, first 100 sq cm or less; trunk, arms, legsCommonly billed for application of a dermal substitute as the primary procedural CPT when applicable alongside product billing with A2006.
    15777Implantation of biologic graft (muscle/fascia/dermis) for soft tissue reinforcement (e.g., hernia)Utilized for more complex reconstructive cases where dermal matrices reinforce soft tissue.
    15100Split-thickness autograft, first 100 sq cm or lessMay be performed in a staged approach after neodermis formation under the dermal matrix.
    97597Debridement wound, selective debridement including topical application(s), first 20 sq cmOften performed in clinic or bedside before definitive operative management with a dermal matrix.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207L00000X
    207P00000X
    231H00000X
    207K00000X
    246Z00000X
    207RH0005X
    261QV0200X
    323P00000X

    Related ICD-10-CM Codes

    24 rows

    ICD-10-CM CodeDescription
    A49.02Methicillin resistant Staphylococcus aureus infection, unspecified site
    E10.621Type 1 diabetes mellitus with foot ulcer
    E11.621Type 2 diabetes mellitus with foot ulcer
    L03.116Cellulitis of left lower limb
    L89.213Pressure ulcer of right hip, stage 3
    L89.314Pressure ulcer of right buttock, stage 4
    L89.524Pressure ulcer of left ankle, stage 4
    L89.624Pressure ulcer of left heel, stage 4
    L97.101Non-pressure chronic ulcer of unspecified thigh limited to breakdown of skin
    L97.209Non-pressure chronic ulcer of unspecified calf with unspecified severity

    Showing 1–10 of 24

    Related Payer Policy Updates

    Specialty: Plastic/Reconstructive Surgery1 / 3

    10 rows

    PolicyPayerEffective Date
    Breast Reduction (Mammoplasty) SurgeryKaiser Permanente2027-02-01
    Rhinoplasty Medical Necessity and Site of ServicePremera Bluecross2026-10-14
    Surgical Treatments for LymphedemaProvidence Health Plan2026-10-01
    Surgical Treatment of Lipedema and LymphedemaPremera Bluecross2026-10-01
    Breast Reduction Surgery (for North Carolina Only)UnitedHealthcare2026-10-01
    Cosmetic, Reconstructive, or Plastic SurgeryUnitedHealthcare2026-10-01
    Surgical Treatments for LymphedemaProvidence Health Plan2026-10-01
    Reduction Mammoplasty (Breast Reduction Surgery) for Symptomatic MacromastiaWPS Health Insurance2026-10-01
    Reduction MammoplastyModa Health2026-10-01
    Treatment for Lipedema (Lipectomy/Liposuction)Moda Health2026-10-01

    Related Codes

    HCPCS-A2001-INNOVAMATRIX-PER-SQ-CM

    HCPCS Level II A2001: Innovamatrix ac, per square centimeter (add-on)

    HCPCS-A2002-MIRRAGEN-ADVANCED-WOUND-MATRIX-PER-CM2

    HCPCS Level II A2002: Mirragen Advanced Wound Matrix, per sq cm

    HCPCS-A2004-XCELLISTEM-1MG-SPECIALTY-BIOLOGIC-SUPPLY

    HCPCS A2004: Xcellistem, 1 mg

    HCPCS-A2005-MICROLYTE-MATRIX-WOUND-BIOMATERIAL-PER-CM2

    HCPCS Level II A2005: Microlyte Matrix, Per Square Centimeter

    HCPCS-A2007-RESTRATA-PER-SQ-CM-TOPICAL-WOUND-MATERIAL

    HCPCS Level II A2007: Restrata, per Square Centimeter (Add-on)

    HCPCS-A2008-THERAGENESIS-PER-SQUARE-CENTIMETER-ADD-ON

    HCPCS Level II A2008: Theragenesis, Per Square Centimeter

    HCPCS-A2009-SYMPHONY-PER-SQUARE-CENTIMETER-ADD-ON

    HCPCS Level II A2009: Symphony, per Square Centimeter (Add-on)

    HCPCS-A2010-APIS-PER-SQUARE-CENTIMETER-TOPICAL-BIOLOGIC-ADD-ON

    HCPCS Level II A2010: Apis Topical Product Per Square Centimeter

    HCPCS-A2011-SUPRA-SDRM-PER-SQ-CM-ADD-ON

    HCPCS Level II A2011: Suprasdrm per Square Centimeter (Add-on)

    HCPCS-A2012-SUPRATHEL-PER-SQUARE-CENTIMETER

    HCPCS A2012: Suprathel Skin Substitute, Per cm2

    Showing 1–10 of 43

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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