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    OpenPayerBilling CodesMatrix for Wound Management (Placental, Equine, Synthetic)HCPCS hcpcs-a2002-mirragen-advanced-wound-matrix-per-cm2
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    HCPCS Level II A2002: Mirragen Advanced Wound Matrix, per sq cm

    Medicare pays $133 on average nationally for this procedure.

    HCPCS Level II code A2002 describes the Mirragen advanced wound matrix billed per square centimeter as an add-on product used in wound care procedures; this represents a biologically active wound matrix product supplied to support tissue regeneration during surgical or procedural wound management, typically provided in ambulatory surgical centers or hospital outpatient departments as an adjunct to a primary wound procedure.

    For related coverage guidance, see recent payer policy updates: Breast Reduction (Mammoplasty) Surgery, Rhinoplasty Medical Necessity and Site of Service, Surgical Treatments for Lymphedema.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult with a chronic, non-healing full‑thickness lower extremity wound (for example, a diabetic foot ulcer or venous stasis ulcer) that has failed conservative wound care (debridement, dressings, offloading, compression) and requires advanced biologic matrix application. The wound care specialist (podiatrist, vascular surgeon, or wound care physician) evaluates the wound in an outpatient wound clinic or ambulatory surgery center. After assessing vascular status, controlling infection, and performing sharp debridement under local anesthesia, the provider measures the wound bed and applies the Mirragen advanced wound matrix product to the prepared wound surface, billed using A2002 per square centimeter as an add-on to the primary debridement or other primary wound procedure. Typical workflow steps include pre-procedure assessment and consent, infection control (topical/systemic as indicated), sharp debridement, hemostasis, application of the matrix to exact wound dimensions, securement with appropriate dressings, patient education on offloading and dressing care, and scheduled follow-up visits for reassessment and possible repeat applications.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    11042Debridement, subcutaneous tissue, first 20 sq cm or lessOften performed immediately before matrix application to prepare a viable wound bed.
    11043Debridement, muscle and/or fascia, first 20 sq cm or lessUsed when deeper debridement is necessary prior to placement of an advanced matrix.
    11730Partial or complete nail avulsion (simple)May be performed in conjunction for diabetic foot infections where nail pathology contributes to ulceration.
    97597Debridement (selective) by skilled therapist; per session, initial 20 sq cm or lessMay be billed for skilled debridement sessions in outpatient wound clinics preceding matrix application.
    15271Application of skin substitute graft to trunk, arms, legs; first 100 sq cmRepresents application of biologic/skin substitute material and is clinically analogous in workflow to matrix application; used when primary procedure codes for grafts are reported alongside A2002 as an add-on.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207P00000X
    207L00000X
    207K00000X
    207RH0000X
    207RC0000X
    332800000X
    2279G0305X
    246XC2903X

    Related Payer Policy Updates

    Specialty: Plastic/Reconstructive Surgery1 / 3

    10 rows

    PolicyPayerEffective Date
    Breast Reduction (Mammoplasty) SurgeryKaiser Permanente2027-02-01
    Rhinoplasty Medical Necessity and Site of ServicePremera Bluecross2026-10-14
    Surgical Treatments for LymphedemaProvidence Health Plan2026-10-01
    Surgical Treatment of Lipedema and LymphedemaPremera Bluecross2026-10-01
    Breast Reduction Surgery (for North Carolina Only)UnitedHealthcare2026-10-01
    Cosmetic, Reconstructive, or Plastic SurgeryUnitedHealthcare2026-10-01
    Surgical Treatments for LymphedemaProvidence Health Plan2026-10-01
    Reduction Mammoplasty (Breast Reduction Surgery) for Symptomatic MacromastiaWPS Health Insurance2026-10-01
    Reduction MammoplastyModa Health2026-10-01
    Treatment for Lipedema (Lipectomy/Liposuction)Moda Health2026-10-01

    Related Codes

    HCPCS-A2001-INNOVAMATRIX-PER-SQ-CM

    HCPCS Level II A2001: Innovamatrix ac, per square centimeter (add-on)

    HCPCS-A2004-XCELLISTEM-1MG-SPECIALTY-BIOLOGIC-SUPPLY

    HCPCS A2004: Xcellistem, 1 mg

    HCPCS-A2005-MICROLYTE-MATRIX-WOUND-BIOMATERIAL-PER-CM2

    HCPCS Level II A2005: Microlyte Matrix, Per Square Centimeter

    HCPCS-A2006-NOVOSORB-DERMAL-MATRIX-PER-CM

    HCPCS A2006: Novosorb Synpath Dermal Matrix, per cm2

    HCPCS-A2007-RESTRATA-PER-SQ-CM-TOPICAL-WOUND-MATERIAL

    HCPCS Level II A2007: Restrata, per Square Centimeter (Add-on)

    HCPCS-A2008-THERAGENESIS-PER-SQUARE-CENTIMETER-ADD-ON

    HCPCS Level II A2008: Theragenesis, Per Square Centimeter

    HCPCS-A2009-SYMPHONY-PER-SQUARE-CENTIMETER-ADD-ON

    HCPCS Level II A2009: Symphony, per Square Centimeter (Add-on)

    HCPCS-A2010-APIS-PER-SQUARE-CENTIMETER-TOPICAL-BIOLOGIC-ADD-ON

    HCPCS Level II A2010: Apis Topical Product Per Square Centimeter

    HCPCS-A2011-SUPRA-SDRM-PER-SQ-CM-ADD-ON

    HCPCS Level II A2011: Suprasdrm per Square Centimeter (Add-on)

    HCPCS-A2012-SUPRATHEL-PER-SQUARE-CENTIMETER

    HCPCS A2012: Suprathel Skin Substitute, Per cm2

    Showing 1–10 of 43

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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