ICD-10-CM Code For Toxic Encephalopathy: Group Overview

The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group G92 includes diagnoses for encephalopathy due to toxins, drugs, metabolic agents, and systemic poisons that impair cerebral function. These ICD-10-CM diagnosis codes are used to document clinical scenarios of acute or chronic brain dysfunction caused by exposure to specific toxic substances, capturing severity and neurologic manifestations. Accurate coding within the ICD-10-CM G92 group supports proper claim adjudication, complete clinical documentation, or appropriate reimbursement.

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ICD-10-CM G92: Toxic Encephalopathy Overview

The diagnoses in this group represent brain dysfunction caused by toxic exposure to drugs, chemicals, metabolic byproducts, or other systemic toxins and affect the central nervous system. Toxic encephalopathies can present with altered mental status, cognitive impairment, seizures, or focal neurologic signs depending on exposure and severity. Accurate coding matters for reimbursement because it links clinical findings to toxic etiologies and supports medically necessary care and appropriate claim adjudication.

When to Use

Use a code from this group when clinical documentation identifies encephalopathy attributable to a toxic exposure, poisoning, or adverse effect of a substance. Select codes that reflect the specific toxin when documented and include indicators of acute versus chronic presentations and associated neurologic findings.

ICD-10-CM Codes

8 rows

ICD-10-CM Code	Description
G92.00	Immune effector cell-associated neurotoxicity syndrome, grade unspecified
G92.01	Immune effector cell-associated neurotoxicity syndrome, grade 1
G92.02	Immune effector cell-associated neurotoxicity syndrome, grade 2
G92.03	Immune effector cell-associated neurotoxicity syndrome, grade 3
G92.04	Immune effector cell-associated neurotoxicity syndrome, grade 4
G92.05	Immune effector cell-associated neurotoxicity syndrome, grade 5
G92.8	Other toxic encephalopathy
G92.9	Unspecified toxic encephalopathy

DRG Codes

7 rows

DRG Code	Description
023	Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis with MCC or Antineoplastic Implant or Epilepsy with Neurostimulator
024	Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis without MCC
091	Other Disorders of Nervous System with MCC
092	Other Disorders of Nervous System with CC
093	Other Disorders of Nervous System without CC/MCC
791	Prematurity with Major Problems
793	Full Term Neonate with Major Problems

Typical Clinical Scenarios

An adult is brought to the emergency department with sudden confusion, disorientation, and altered level of consciousness after a workplace exposure to high levels of organic solvent fumes; initial exam shows reduced attention and memory impairment without focal neurologic deficits. Toxic exposure is suspected as the precipitant of acute diffuse brain dysfunction, so an acute toxic encephalopathy code is assigned to capture the substance-related acute neurologic impairment. Typical codes: G92.0.
An elderly patient in a skilled nursing facility develops progressive cognitive decline, gait disturbance, and behavioral changes over weeks while receiving chronic high-dose opioid therapy and multiple sedating medications; clinicians suspect cumulative drug toxicity contributing to encephalopathy rather than primary neurodegenerative disease. Because the presentation reflects an ongoing toxic metabolic effect on brain function related to medication exposure, a subacute or chronic toxic encephalopathy code is used to document the condition and guide medication review. Typical codes: G92.02, G92.01.
A hospitalized patient with hepatic failure develops fluctuating consciousness, asterixis, and confusion as a complication of advanced liver disease and known toxin accumulation; the team documents an encephalopathic state attributable to systemic toxin retention. The encephalopathy in this case is recorded as a toxic/metabolic encephalopathy as a comorbidity complicating the inpatient course and influencing management and prognosis. Typical codes: G92.03, G92.9.

ICD-10-CM Code For Disorders Of Autonomic Nervous System: Group Overview

G91-HYDROCEPHALUS

ICD-10-CM Code For Hydrocephalus: Group Overview

G93-OTHER-DISORDERS-OF-BRAIN

ICD-10-CM Code For Other Disorders Of Brain: Group Overview

G94-OTHER-DISORDERS-OF-BRAIN

ICD-10-CM Code For Other Disorders Of Brain In Diseases Classified Elsewhere: Group Overview

G95-OTHER-AND-UNSPECIFIED-SPINAL-CORD

ICD-10-CM Code For Other And Unspecified Diseases Of Spinal Cord: Group Overview

G96-OTHER-DISORDERS-OF-CENTRAL-NERVOUS-SYSTEM

ICD-10-CM Code For Other Disorders Of Central Nervous System: Group Overview

G97-INTRAOPERATIVE-AND-POSTPROCEDURAL-NERVOUS-SYSTEM

ICD-10-CM Code For Intraoperative And Postprocedural Complications Of Nervous System: Group Overview

G98-OTHER-NERVOUS-SYSTEM-DISORDERS

ICD-10-CM Code For Other Disorders Of Nervous System Not Elsewhere Classified: Group Overview

G99-OTHER-DISORDERS-OF-NERVOUS-SYSTEM

ICD-10-CM Code For Other Disorders Of Nervous System In Diseases Classified Elsewhere: Group Overview

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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When to Use

ICD-10-CM Codes

8 rows

ICD-10-CM Code	Description
G92.00	Immune effector cell-associated neurotoxicity syndrome, grade unspecified
G92.01	Immune effector cell-associated neurotoxicity syndrome, grade 1
G92.02	Immune effector cell-associated neurotoxicity syndrome, grade 2
G92.03	Immune effector cell-associated neurotoxicity syndrome, grade 3
G92.04	Immune effector cell-associated neurotoxicity syndrome, grade 4
G92.05	Immune effector cell-associated neurotoxicity syndrome, grade 5
G92.8	Other toxic encephalopathy
G92.9	Unspecified toxic encephalopathy

DRG Codes

7 rows

DRG Code	Description
023	Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis with MCC or Antineoplastic Implant or Epilepsy with Neurostimulator
024	Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis without MCC
091	Other Disorders of Nervous System with MCC
092	Other Disorders of Nervous System with CC
093	Other Disorders of Nervous System without CC/MCC
791	Prematurity with Major Problems
793	Full Term Neonate with Major Problems

Typical Clinical Scenarios

An adult is brought to the emergency department with sudden confusion, disorientation, and altered level of consciousness after a workplace exposure to high levels of organic solvent fumes; initial exam shows reduced attention and memory impairment without focal neurologic deficits. Toxic exposure is suspected as the precipitant of acute diffuse brain dysfunction, so an acute toxic encephalopathy code is assigned to capture the substance-related acute neurologic impairment. Typical codes: G92.0.
An elderly patient in a skilled nursing facility develops progressive cognitive decline, gait disturbance, and behavioral changes over weeks while receiving chronic high-dose opioid therapy and multiple sedating medications; clinicians suspect cumulative drug toxicity contributing to encephalopathy rather than primary neurodegenerative disease. Because the presentation reflects an ongoing toxic metabolic effect on brain function related to medication exposure, a subacute or chronic toxic encephalopathy code is used to document the condition and guide medication review. Typical codes: G92.02, G92.01.
A hospitalized patient with hepatic failure develops fluctuating consciousness, asterixis, and confusion as a complication of advanced liver disease and known toxin accumulation; the team documents an encephalopathic state attributable to systemic toxin retention. The encephalopathy in this case is recorded as a toxic/metabolic encephalopathy as a comorbidity complicating the inpatient course and influencing management and prognosis. Typical codes: G92.03, G92.9.

ICD-10-CM Code For Disorders Of Autonomic Nervous System: Group Overview

G91-HYDROCEPHALUS

ICD-10-CM Code For Hydrocephalus: Group Overview

G93-OTHER-DISORDERS-OF-BRAIN

ICD-10-CM Code For Other Disorders Of Brain: Group Overview

G94-OTHER-DISORDERS-OF-BRAIN

ICD-10-CM Code For Other Disorders Of Brain In Diseases Classified Elsewhere: Group Overview

G95-OTHER-AND-UNSPECIFIED-SPINAL-CORD

ICD-10-CM Code For Other And Unspecified Diseases Of Spinal Cord: Group Overview

G96-OTHER-DISORDERS-OF-CENTRAL-NERVOUS-SYSTEM

ICD-10-CM Code For Other Disorders Of Central Nervous System: Group Overview

G97-INTRAOPERATIVE-AND-POSTPROCEDURAL-NERVOUS-SYSTEM

ICD-10-CM Code For Intraoperative And Postprocedural Complications Of Nervous System: Group Overview

G98-OTHER-NERVOUS-SYSTEM-DISORDERS

ICD-10-CM Code For Other Disorders Of Nervous System Not Elsewhere Classified: Group Overview

G99-OTHER-DISORDERS-OF-NERVOUS-SYSTEM

ICD-10-CM Code For Other Disorders Of Nervous System In Diseases Classified Elsewhere: Group Overview

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

ICD-10-CM Code For Toxic Encephalopathy: Group Overview

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ICD-10-CM G92: Toxic Encephalopathy Overview

ICD-10-CM Code For Toxic Encephalopathy: Group Overview

Sign up for ICD-10-CM Code For Toxic Encephalopathy: Group Overview policy alerts

ICD-10-CM G92: Toxic Encephalopathy Overview

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

References

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

References

ICD-10-CM Code For Toxic Encephalopathy: Group Overview

Sign up for ICD-10-CM Code For Toxic Encephalopathy: Group Overview policy alerts

ICD-10-CM G92: Toxic Encephalopathy Overview

ICD-10-CM Code For Toxic Encephalopathy: Group Overview

Sign up for ICD-10-CM Code For Toxic Encephalopathy: Group Overview policy alerts

ICD-10-CM G92: Toxic Encephalopathy Overview

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

What clinical scenarios does ICD-10-CM group `G92` cover?

Which specific diagnosis codes are included in the G92 group?

How does accurate coding within `G92` affect reimbursement?

Which DRGs are related to diagnoses in the `G92` group?

How are immune effector cell-associated neurotoxicity syndromes represented in the `G92` group?

References

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

What clinical scenarios does ICD-10-CM group `G92` cover?

Which specific diagnosis codes are included in the G92 group?

How does accurate coding within `G92` affect reimbursement?

Which DRGs are related to diagnoses in the `G92` group?

How are immune effector cell-associated neurotoxicity syndromes represented in the `G92` group?

References