ICD-10-CM Code For Deficiency Of Other B Group Vitamins: Group Overview

The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group E53 includes deficiencies of B vitamins other than thiamine and folate, covering conditions such as riboflavin, niacin, pyridoxine, and cobalamin-related disorders when specified as other B group vitamin deficiencies. These ICD-10-CM diagnosis codes are used to document clinical scenarios related to nutrient deficiency states that may present with neurologic, dermatologic, or hematologic manifestations and to capture severity, chronicity, or complications. Accurate coding within the ICD-10-CM E53 group supports proper claim adjudication and complete clinical documentation and appropriate reimbursement.

Customize your policy alerts

Sign up for ICD-10-CM Code For Deficiency Of Other B Group Vitamins: Group Overview policy alerts

Get alerted when relevant policies change without checking for updates manually.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

ICD-10-CM E53: Deficiency Of Other B Group Vitamins Overview

This group includes vitamin B deficiencies other than thiamine and folate that affect metabolic and neurologic function. It targets clinical conditions caused by insufficient intake, malabsorption, or increased requirement of B vitamins and may involve peripheral nerves, the central nervous system, or hematologic systems. Accurate coding ensures that clinical complexity is documented and supports appropriate reimbursement for nutrition-related care.

When to Use

Use codes from this group when a documented clinical assessment attributes symptoms or laboratory evidence to deficiency of B vitamins other than thiamine and folate. Apply these codes to capture the specific vitamin involved, the presence of complications, and the clinical severity as documented in the medical record.

ICD-10-CM Codes

4 rows

ICD-10-CM Code	Description
E53.0	Riboflavin deficiency
E53.1	Pyridoxine deficiency
E53.8	Deficiency of other specified B group vitamins
E53.9	Vitamin B deficiency, unspecified

DRG Codes

2 rows

DRG Code	Description
640	Miscellaneous Disorders of Nutrition, Metabolism, Fluids and Electrolytes with MCC
641	Miscellaneous Disorders of Nutrition, Metabolism, Fluids and Electrolytes without MCC

Typical Clinical Scenarios

An elderly patient with progressive peripheral neuropathy, glossitis, and angular cheilosis presents to primary care complaining of fatigue and numbness in the feet over several months; dietary history reveals poor intake of meat and dairy and chronic alcohol use, and laboratory testing shows low serum levels of thiamine and other B vitamins. A deficiency of other B group vitamins is assigned to explain the multisystem signs related to insufficient dietary intake and malnutrition. Typical codes: E53.8, E53.9
A middle-aged patient with chronic pancreatitis and malabsorption is hospitalized for unintentional weight loss, watery diarrhea, and macrocytic anemia; evaluation demonstrates malabsorption of fat- and water-soluble vitamins with laboratory evidence consistent with a documented deficiency of pyridoxine (vitamin B6). A specific code from this group is used to capture the nutritional deficiency secondary to malabsorption as part of the inpatient problem list. Typical codes: E53.1, E53.8
A postpartum woman who has been exclusively breastfeeding and following a restrictive vegan diet presents to urgent care with severe dermatitis, irritability, and seizures; workup reveals marked deficiency of niacin and other B vitamins with neurologic and dermatologic manifestations requiring supplementation. The encounter is coded to reflect the acute nutritional deficiency contributing to the neurocutaneous findings and need for treatment. Typical codes: E53.0, E53.8

Related Codes

E50-VITAMIN-A-DEFICIENCY

ICD-10-CM Code For Vitamin A Deficiency: Group Overview

E51-THIAMINE-DEFICIENCY

ICD-10-CM Code For Thiamine Deficiency: Group Overview

E52-NIACIN-DEFICIENCY-PELLAGRA

ICD-10-CM Code For Niacin Deficiency [Pellagra]: Group Overview

E54-ASCORBIC-ACID-DEFICIENCY

ICD-10-CM Code For Ascorbic Acid Deficiency: Group Overview

E55-VITAMIN-D-DEFICIENCY

ICD-10-CM Code For Vitamin D Deficiency: Group Overview

E56-OTHER-VITAMIN-DEFICIENCIES

ICD-10-CM Code For Other Vitamin Deficiencies: Group Overview

E58-DIETARY-CALCIUM-DEFICIENCY

ICD-10-CM Code For Dietary Calcium Deficiency: Group Overview

E59-DIETARY-SELENIUM-DEFICIENCY

ICD-10-CM Code For Dietary Selenium Deficiency: Group Overview

E60-DIETARY-ZINC-DEFICIENCY

ICD-10-CM Code For Dietary Zinc Deficiency: Group Overview

E61-DEFICIENCY-OF-OTHER-NUTRIENT-ELEMENTS

ICD-10-CM Code For Deficiency Of Other Nutrient Elements: Group Overview

Showing 1–10 of 12

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

Explore openpayer tools

View all tools

When to Use

ICD-10-CM Codes

4 rows

ICD-10-CM Code	Description
E53.0	Riboflavin deficiency
E53.1	Pyridoxine deficiency
E53.8	Deficiency of other specified B group vitamins
E53.9	Vitamin B deficiency, unspecified

DRG Codes

2 rows

DRG Code	Description
640	Miscellaneous Disorders of Nutrition, Metabolism, Fluids and Electrolytes with MCC
641	Miscellaneous Disorders of Nutrition, Metabolism, Fluids and Electrolytes without MCC

Typical Clinical Scenarios

An elderly patient with progressive peripheral neuropathy, glossitis, and angular cheilosis presents to primary care complaining of fatigue and numbness in the feet over several months; dietary history reveals poor intake of meat and dairy and chronic alcohol use, and laboratory testing shows low serum levels of thiamine and other B vitamins. A deficiency of other B group vitamins is assigned to explain the multisystem signs related to insufficient dietary intake and malnutrition. Typical codes: E53.8, E53.9
A middle-aged patient with chronic pancreatitis and malabsorption is hospitalized for unintentional weight loss, watery diarrhea, and macrocytic anemia; evaluation demonstrates malabsorption of fat- and water-soluble vitamins with laboratory evidence consistent with a documented deficiency of pyridoxine (vitamin B6). A specific code from this group is used to capture the nutritional deficiency secondary to malabsorption as part of the inpatient problem list. Typical codes: E53.1, E53.8
A postpartum woman who has been exclusively breastfeeding and following a restrictive vegan diet presents to urgent care with severe dermatitis, irritability, and seizures; workup reveals marked deficiency of niacin and other B vitamins with neurologic and dermatologic manifestations requiring supplementation. The encounter is coded to reflect the acute nutritional deficiency contributing to the neurocutaneous findings and need for treatment. Typical codes: E53.0, E53.8

Related Codes

E50-VITAMIN-A-DEFICIENCY

ICD-10-CM Code For Vitamin A Deficiency: Group Overview

E51-THIAMINE-DEFICIENCY

ICD-10-CM Code For Thiamine Deficiency: Group Overview

E52-NIACIN-DEFICIENCY-PELLAGRA

ICD-10-CM Code For Niacin Deficiency [Pellagra]: Group Overview

E54-ASCORBIC-ACID-DEFICIENCY

ICD-10-CM Code For Ascorbic Acid Deficiency: Group Overview

E55-VITAMIN-D-DEFICIENCY

ICD-10-CM Code For Vitamin D Deficiency: Group Overview

E56-OTHER-VITAMIN-DEFICIENCIES

ICD-10-CM Code For Other Vitamin Deficiencies: Group Overview

E58-DIETARY-CALCIUM-DEFICIENCY

ICD-10-CM Code For Dietary Calcium Deficiency: Group Overview

E59-DIETARY-SELENIUM-DEFICIENCY

ICD-10-CM Code For Dietary Selenium Deficiency: Group Overview

E60-DIETARY-ZINC-DEFICIENCY

ICD-10-CM Code For Dietary Zinc Deficiency: Group Overview

E61-DEFICIENCY-OF-OTHER-NUTRIENT-ELEMENTS

ICD-10-CM Code For Deficiency Of Other Nutrient Elements: Group Overview

Showing 1–10 of 12

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

ICD-10-CM Code For Deficiency Of Other B Group Vitamins: Group Overview

Sign up for ICD-10-CM Code For Deficiency Of Other B Group Vitamins: Group Overview policy alerts

ICD-10-CM E53: Deficiency Of Other B Group Vitamins Overview

ICD-10-CM Code For Deficiency Of Other B Group Vitamins: Group Overview

Sign up for ICD-10-CM Code For Deficiency Of Other B Group Vitamins: Group Overview policy alerts

ICD-10-CM E53: Deficiency Of Other B Group Vitamins Overview

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which ICD-10-CM codes are included in the E53 group?

What clinical manifestations are associated with E53 group diagnoses?

How does accurate coding within E53 support reimbursement?

When should a coder choose `E53.8` versus `E53.9`?

Which DRGs are related to the E53 diagnoses for hospital grouping?

References

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which ICD-10-CM codes are included in the E53 group?

What clinical manifestations are associated with E53 group diagnoses?

How does accurate coding within E53 support reimbursement?

When should a coder choose `E53.8` versus `E53.9`?

Which DRGs are related to the E53 diagnoses for hospital grouping?

References