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    v1.0.28
    OpenPayerBilling CodesOther nutritional deficienciesICD-10-CM e52-niacin-deficiency-pellagra
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    ICD-10-CM Code For Niacin Deficiency [Pellagra]: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group E52 includes diagnoses for niacin deficiency and pellagra, covering manifestations such as dermatitis, diarrhea, and neuropsychiatric symptoms resulting from inadequate niacin intake or metabolism. These ICD-10-CM diagnosis codes are used to document clinical scenarios involving nutritional deficiency with systemic involvement, capturing severity, presence of complications, and associated conditions. Accurate coding within the ICD-10-CM E52 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM E52: Niacin Deficiency [Pellagra] Overview

    This group represents niacin deficiency, commonly known as pellagra, affecting multiple systems including dermatologic, gastrointestinal, and neurologic manifestations. The codes target nutrient deficiency conditions caused by inadequate dietary niacin or tryptophan metabolism. Accurate coding matters for appropriate clinical documentation and reimbursement because it captures disease severity and associated complications.

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    When to Use

    Use a code from this group when a documented diagnosis of niacin deficiency or pellagra is present and being treated or evaluated. Assign codes that reflect the specific manifestations and any associated complications to accurately represent clinical severity.

    ICD-10-CM Codes

    1 rows

    ICD-10-CM CodeDescription
    E52Niacin deficiency [pellagra]

    DRG Codes

    2 rows

    DRG CodeDescription
    640Miscellaneous Disorders of Nutrition, Metabolism, Fluids and Electrolytes with MCC
    641Miscellaneous Disorders of Nutrition, Metabolism, Fluids and Electrolytes without MCC

    Typical Clinical Scenarios

    • A middle-aged patient with chronic alcohol use disorder presents to the emergency department with progressive diarrhea, dermatitis (symmetric scaly rash on sun-exposed areas), and new-onset confusion. Laboratory evaluation and history reveal poor nutrition and niacin-poor diet; the clinical triad suggests pellagra leading to acute neurocognitive changes prompting urgent treatment and coding. Typical codes: E52
    • An elderly nursing home resident with long-standing malabsorptive bowel disease reports months of progressive skin hyperpigmentation, mucosal glossitis, and intermittent diarrhea without acute neurologic decline; the care team documents a chronic nutritional deficiency due to inadequate dietary intake and malabsorption, and assigns a diagnosis reflecting niacin deficiency as part of the resident’s ongoing problem list. Typical codes: E52
    • A patient hospitalized for severe burns develops prolonged enteral feeding interruptions and subsequently manifests delirium, dermatitis, and watery stools; the treating team identifies a hospital-acquired deficiency of niacin contributing to the neurocutaneous symptoms and records it as a comorbid condition affecting management. Typical codes: E52

    Related Codes

    E50-VITAMIN-A-DEFICIENCY

    ICD-10-CM Code For Vitamin A Deficiency: Group Overview

    E51-THIAMINE-DEFICIENCY

    ICD-10-CM Code For Thiamine Deficiency: Group Overview

    E53-DEFICIENCY-OF-OTHER-B-GROUP-VITAMINS

    ICD-10-CM Code For Deficiency Of Other B Group Vitamins: Group Overview

    E54-ASCORBIC-ACID-DEFICIENCY

    ICD-10-CM Code For Ascorbic Acid Deficiency: Group Overview

    E55-VITAMIN-D-DEFICIENCY

    ICD-10-CM Code For Vitamin D Deficiency: Group Overview

    E56-OTHER-VITAMIN-DEFICIENCIES

    ICD-10-CM Code For Other Vitamin Deficiencies: Group Overview

    E58-DIETARY-CALCIUM-DEFICIENCY

    ICD-10-CM Code For Dietary Calcium Deficiency: Group Overview

    E59-DIETARY-SELENIUM-DEFICIENCY

    ICD-10-CM Code For Dietary Selenium Deficiency: Group Overview

    E60-DIETARY-ZINC-DEFICIENCY

    ICD-10-CM Code For Dietary Zinc Deficiency: Group Overview

    E61-DEFICIENCY-OF-OTHER-NUTRIENT-ELEMENTS

    ICD-10-CM Code For Deficiency Of Other Nutrient Elements: Group Overview

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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