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    v1.0.28
    OpenPayerBilling CodesOther disorders of glucose regulation and pancreatic internal secretionICD-10-CM e16-other-disorders-of-pancreatic-secretion
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    ICD-10-CM Code For Other Disorders Of Pancreatic Internal Secretion: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group E16 includes disorders of pancreatic internal secretion such as hypoglycemia not elsewhere classified, hyperinsulinemia, and other specified abnormalities of insulin secretion and glucose regulation. These ICD-10-CM diagnosis codes are used to document clinical scenarios involving dysregulated insulin production or action, symptomatic hypoglycemia or hyperinsulinemic states, and complications related to pancreatic endocrine function. Accurate coding within the ICD-10-CM E16 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM E16: Other Disorders Of Pancreatic Internal Secretion Overview

    The ICD-10-CM E16 group encompasses disorders of pancreatic internal secretion affecting glucose regulation and pancreatic hormone balance, such as hypoglycemia not elsewhere classified, hyperinsulinemia, and other specified disorders of insulin secretion. These conditions target the endocrine pancreas and systemic metabolic control. Accurate coding matters for appropriate claim adjudication and to reflect clinical complexity that can affect reimbursement and care coordination.

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    When to Use

    Assign a code from this group when a patient has documented hypoglycemia, hyperinsulinemia, or another specified disorder of pancreatic hormone secretion that is the focus of care or affects treatment decisions. Use these codes to reflect the specific clinical presentation, severity, and any related complications when documented in the medical record.

    ICD-10-CM Codes

    10 rows

    ICD-10-CM CodeDescription
    E16.0Drug-induced hypoglycemia without coma
    E16.1Other hypoglycemia
    E16.2Hypoglycemia, unspecified
    E16.3Increased secretion of glucagon
    E16.4Increased secretion of gastrin
    E16.8Other specified disorders of pancreatic internal secretion
    E16.9Disorder of pancreatic internal secretion, unspecified
    E16.A1Hypoglycemia level 1
    E16.A2Hypoglycemia level 2
    E16.A3Hypoglycemia level 3

    DRG Codes

    8 rows

    DRG CodeDescription
    380Complicated Peptic Ulcer with MCC
    381Complicated Peptic Ulcer with CC
    382Complicated Peptic Ulcer without CC/MCC
    640Miscellaneous Disorders of Nutrition, Metabolism, Fluids and Electrolytes with MCC
    641Miscellaneous Disorders of Nutrition, Metabolism, Fluids and Electrolytes without MCC
    643Endocrine Disorders with MCC
    644Endocrine Disorders with CC
    645Endocrine Disorders without CC/MCC

    Related Codes

    E15-NONDIABETIC-HYPOGLYCEMIC-COMA

    ICD-10-CM Code For Nondiabetic Hypoglycemic Coma: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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