ICD-10-CM Code For Immunodeficiency With Predominantly Antibody Defects: Group Overview

The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group D80 includes diagnoses of predominantly antibody-related immunodeficiencies such as agammaglobulinemia, hypogammaglobulinemia, and common variable immunodeficiency that impair humoral immunity. These ICD-10-CM diagnosis codes are used to document clinical scenarios involving recurrent infections, reduced immunoglobulin levels, and immune dysfunction, capturing disease severity and treatment complexity. Accurate coding within the ICD-10-CM D80 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

Customize your policy alerts

Sign up for ICD-10-CM Code For Immunodeficiency With Predominantly Antibody Defects: Group Overview policy alerts

Get alerted when relevant policies change without checking for updates manually.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

ICD-10-CM D80: Immunodeficiency With Predominantly Antibody Defects Overview

This group represents primary and secondary disorders characterized by impaired antibody production and humoral immune dysfunction affecting the immune system. It includes conditions such as agammaglobulinemia and common variable immunodeficiency that primarily target B-cell function and antibody-mediated immunity. Accurate coding is important because it documents disease severity and complexity, which impacts clinical management and reimbursement.

When to Use

Use a code from this group when a patient has documented antibody deficiency demonstrated by low immunoglobulin levels, recurrent or unusual infections, or a known diagnosis of a B-cell related immunodeficiency. Assign codes that reflect the specific diagnosis and severity, including any documented complications or associated organ involvement.

ICD-10-CM Codes

10 rows

ICD-10-CM Code	Description
D80.0	Hereditary hypogammaglobulinemia
D80.1	Nonfamilial hypogammaglobulinemia
D80.2	Selective deficiency of immunoglobulin A [IgA]
D80.3	Selective deficiency of immunoglobulin G [IgG] subclasses
D80.4	Selective deficiency of immunoglobulin M [IgM]
D80.5	Immunodeficiency with increased immunoglobulin M [IgM]
D80.6	Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia
D80.7	Transient hypogammaglobulinemia of infancy
D80.8	Other immunodeficiencies with predominantly antibody defects
D80.9	Immunodeficiency with predominantly antibody defects, unspecified

DRG Codes

6 rows

DRG Code	Description
808	Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with MCC
809	Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with CC
810	Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders without CC/MCC
814	Reticuloendothelial and Immunity Disorders with MCC
815	Reticuloendothelial and Immunity Disorders with CC
816	Reticuloendothelial and Immunity Disorders without CC/MCC

Typical Clinical Scenarios

An infant or young child with recurrent, severe bacterial otitis media, pneumonia, and failure to thrive is evaluated by pediatrics after multiple courses of antibiotics and poor response to routine immunizations; laboratory testing demonstrates markedly reduced serum immunoglobulin levels with poor vaccine antibody titers, prompting referral to immunology and initiation of immunoglobulin replacement therapy. Typical codes: D80.0, D80.1
An adult presents to the emergency department with an acute, high-grade fever and rapidly progressive sinopulmonary infection; history reveals long-standing recurrent sinopulmonary infections and laboratory assessment shows low B-cell counts and hypogammaglobulinemia, so admission is for intravenous antibiotics and prompt immunologic evaluation for a primary antibody deficiency. Typical codes: D80.3, D80.6
A middle-aged patient with a known antibody deficiency on chronic immunoglobulin replacement develops chronic diarrhea, weight loss, and new-onset autoimmune cytopenias; this visit is for management of complications of the underlying humoral immunodeficiency and optimization of therapy. Typical codes: D80.4, D80.5

Related Codes

D81-COMBINED-IMMUNODEFICIENCIES

ICD-10-CM Code For Combined Immunodeficiencies: Group Overview

D82-IMMUNODEFICIENCY-WITH-MAJOR-DEFECTS

ICD-10-CM Code For Immunodeficiency Associated With Other Major Defects: Group Overview

D83-COMMON-VARIABLE-IMMUNODEFICIENCY

ICD-10-CM Code For Common Variable Immunodeficiency: Group Overview

D84-OTHER-IMMUNODEFICIENCIES

ICD-10-CM Code For Other Immunodeficiencies: Group Overview

D86-SARCOIDOSIS

ICD-10-CM Code For Sarcoidosis: Group Overview

D89-OTHER-IMMUNE-MECHANISM-DISORDERS

ICD-10-CM Code For Other Disorders Involving The Immune Mechanism Not Elsewhere Classified: Group Overview

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

Explore openpayer tools

View all tools

When to Use

ICD-10-CM Codes

10 rows

ICD-10-CM Code	Description
D80.0	Hereditary hypogammaglobulinemia
D80.1	Nonfamilial hypogammaglobulinemia
D80.2	Selective deficiency of immunoglobulin A [IgA]
D80.3	Selective deficiency of immunoglobulin G [IgG] subclasses
D80.4	Selective deficiency of immunoglobulin M [IgM]
D80.5	Immunodeficiency with increased immunoglobulin M [IgM]
D80.6	Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia
D80.7	Transient hypogammaglobulinemia of infancy
D80.8	Other immunodeficiencies with predominantly antibody defects
D80.9	Immunodeficiency with predominantly antibody defects, unspecified

DRG Codes

6 rows

DRG Code	Description
808	Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with MCC
809	Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with CC
810	Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders without CC/MCC
814	Reticuloendothelial and Immunity Disorders with MCC
815	Reticuloendothelial and Immunity Disorders with CC
816	Reticuloendothelial and Immunity Disorders without CC/MCC

Typical Clinical Scenarios

An infant or young child with recurrent, severe bacterial otitis media, pneumonia, and failure to thrive is evaluated by pediatrics after multiple courses of antibiotics and poor response to routine immunizations; laboratory testing demonstrates markedly reduced serum immunoglobulin levels with poor vaccine antibody titers, prompting referral to immunology and initiation of immunoglobulin replacement therapy. Typical codes: D80.0, D80.1
An adult presents to the emergency department with an acute, high-grade fever and rapidly progressive sinopulmonary infection; history reveals long-standing recurrent sinopulmonary infections and laboratory assessment shows low B-cell counts and hypogammaglobulinemia, so admission is for intravenous antibiotics and prompt immunologic evaluation for a primary antibody deficiency. Typical codes: D80.3, D80.6
A middle-aged patient with a known antibody deficiency on chronic immunoglobulin replacement develops chronic diarrhea, weight loss, and new-onset autoimmune cytopenias; this visit is for management of complications of the underlying humoral immunodeficiency and optimization of therapy. Typical codes: D80.4, D80.5

Related Codes

D81-COMBINED-IMMUNODEFICIENCIES

ICD-10-CM Code For Combined Immunodeficiencies: Group Overview

D82-IMMUNODEFICIENCY-WITH-MAJOR-DEFECTS

ICD-10-CM Code For Immunodeficiency Associated With Other Major Defects: Group Overview

D83-COMMON-VARIABLE-IMMUNODEFICIENCY

ICD-10-CM Code For Common Variable Immunodeficiency: Group Overview

D84-OTHER-IMMUNODEFICIENCIES

ICD-10-CM Code For Other Immunodeficiencies: Group Overview

D86-SARCOIDOSIS

ICD-10-CM Code For Sarcoidosis: Group Overview

D89-OTHER-IMMUNE-MECHANISM-DISORDERS

ICD-10-CM Code For Other Disorders Involving The Immune Mechanism Not Elsewhere Classified: Group Overview

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

ICD-10-CM Code For Immunodeficiency With Predominantly Antibody Defects: Group Overview

Sign up for ICD-10-CM Code For Immunodeficiency With Predominantly Antibody Defects: Group Overview policy alerts

ICD-10-CM D80: Immunodeficiency With Predominantly Antibody Defects Overview

ICD-10-CM Code For Immunodeficiency With Predominantly Antibody Defects: Group Overview

Sign up for ICD-10-CM Code For Immunodeficiency With Predominantly Antibody Defects: Group Overview policy alerts

ICD-10-CM D80: Immunodeficiency With Predominantly Antibody Defects Overview

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which diagnoses are included in ICD-10-CM group D80?

What clinical features justify using a code from D80?

How does accurate coding in D80 affect reimbursement and claims?

Which DRGs commonly relate to D80 diagnoses for inpatient categorization?

Are both primary and secondary immunodeficiencies represented in the D80 group?

References

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which diagnoses are included in ICD-10-CM group D80?

What clinical features justify using a code from D80?

How does accurate coding in D80 affect reimbursement and claims?

Which DRGs commonly relate to D80 diagnoses for inpatient categorization?

Are both primary and secondary immunodeficiencies represented in the D80 group?

References