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    OpenPayerBilling CodesPhotodynamic Therapy ProceduresCPT cpt-96573-photodynamic-therapy-photosensitizer-application-lesion
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    CPT 96573: Photodynamic Therapy with Photosensitizer Application

    Medicare pays $228 on average nationally for this procedure.

    CPT code 96573 describes a physician or qualified health care professional applying a photosensitizing drug to a skin or adjacent mucosal lesion followed by exposure to a specific wavelength of light to destroy precancerous cells; this procedure is a photodynamic therapy service typically performed in an ambulatory clinic or outpatient dermatology setting and is reported once per day for the treatment of superficial precancerous lesions.

    For related coverage guidance, see recent payer policy updates: Onychomycosis diagnostic testing and coverage, Topical Acne-Non-Retinoid Products, Dermatology - Vtama Drug Quantity Management Policy - Per Days.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 68-year-old patient with a history of chronic sun exposure presents to a dermatology clinic with multiple actinic keratoses and a field of dysplastic, precancerous lesions on the dorsal hands and forearms. After evaluation by a board-certified dermatologist, the decision is made to perform photodynamic therapy to treat superficial precancerous lesions. On the day of service the patient is prepared in a dermatology procedure room: informed consent is confirmed, lesions are cleansed, a photosensitizing agent is applied to the target lesion(s), and the agent is allowed an incubation period. The provider then exposes the treated area to a specific wavelength light source for the prescribed time to activate the photosensitizer and induce selective cell destruction. Post-procedure wound care instructions are given and a follow-up visit is scheduled.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    11102Tangential biopsy of skin, single lesionPerformed prior to photodynamic therapy to obtain histologic diagnosis of suspicious lesions.
    17000Destruction of premalignant lesions (e.g., actinic keratoses); up to 14 lesionsAn alternative or adjunct treatment; may be used when PDT is not indicated or for smaller numbers of lesions.
    97597Debridement (e.g., topical) — selective debridement for wounds or lesionsMay be performed prior to application of photosensitizer if necrotic tissue requires removal.
    99070Supplies and materials (e.g., noncovered items)Used to report additional supplies such as specialized photosensitizing agents or dressing materials when payer allows separate reporting.
    96573Photodynamic therapy, as describedPrimary procedure code for topical photodynamic therapy to destroy precancerous skin and adjacent mucosa; reportable once per day.

    Related Modifiers

    13 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Showing 1–10 of 13

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207P00000XEmergency Medicine PhysicianAn emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
    208D00000XGeneral Practice PhysicianA physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    207K00000XAllergy & Immunology PhysicianAn allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
    332BD1200XDialysis Equipment & Supplies (DME)Suppliers · Durable Medical Equipment & Medical Supplies
    2279H0200XHome Health Registered Respiratory TherapistHome care fosters individual responsibility for self-management of chronic respiratory conditions. It includes individualized assessment based plans …
    2082S0099XPlastic Surgery Within the Head and Neck (Plastic Surgery) PhysicianA plastic surgeon with additional training in plastic and reconstructive procedures within the head, face, neck and associated structures, including c…
    103G00000XClinical NeuropsychologistA clinical psychologist who applies principles of assessment and intervention based upon the scientific study of human behavior as it relates to norma…

    Related Payer Policy Updates

    Specialty: Dermatology1 / 2

    10 rows

    PolicyPayerEffective Date
    Onychomycosis diagnostic testing and coverageOscar Health2026-10-01
    Topical Acne-Non-Retinoid ProductsCigna2026-08-15
    Dermatology - Vtama Drug Quantity Management Policy - Per DaysCigna2026-08-15
    Medical Necessity Guidelines: Acne and Rosacea Medicationsharvard pilgrim health care2026-08-11
    Pharmacologic Treatment of PsoriasisPremera Bluecross2026-08-01
    Winlevi (clascoterone 1% cream) — Topical AcneCigna2026-08-01
    Spevigo (spesolimab‑sbzo) for generalized pustular psoriasisUnitedHealthcare2026-08-01
    Onychomycosis Testingblue cross blue shield - louisiana2026-08-01
    Spesolimab-sbzo (Spevigoblue cross blue shield - tennessee2026-07-31
    Home ultraviolet light therapy equipment for skin conditionsselect_health2026-07-01

    Related Codes

    CPT-96567-PHOTODYNAMIC-THERAPY-PRECANCEROUS-SKIN-LESION

    CPT 96567: Photodynamic Therapy for Precancerous Skin Lesions

    CPT-96570-PHOTODYNAMIC-THERAPY-DURING-ENDOSCOPY-BRONCHOSCOPY

    CPT 96570: Photodynamic Therapy During Endoscopy or Bronchoscopy

    CPT-96571-PHOTODYNAMIC-THERAPY-DURING-ENDOSCOPY-BRONCHOSCOPY

    CPT 96571: Photodynamic Therapy During Endoscopy or Bronchoscopy

    CPT-96574-PHOTODYNAMIC-THERAPY-FOR-PRECANCEROUS-SKIN-LESIONS

    CPT 96574: Photodynamic Therapy for Precancerous Skin Lesions

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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