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    v1.0.28
    OpenPayerBilling CodesPhotodynamic Therapy ProceduresCPT cpt-96571-photodynamic-therapy-during-endoscopy-bronchoscopy
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    CPT 96571: Photodynamic Therapy During Endoscopy or Bronchoscopy

    Medicare pays $27 on average nationally for this procedure.

    CPT code 96571 describes photodynamic therapy where the provider administers a photosensitizing drug to abnormal tissue and, during the same session as a primary endoscopy or bronchoscopy, exposes the tissue to a specific wavelength of light in 15-minute increments (typical total exposure 38–52 minutes) to destroy cancerous or precancerous cells; service type: photodynamic therapy adjunct to endoscopic or bronchoscopic procedure; typical site of service: outpatient endoscopy or bronchoscopy suite or operating room during the primary procedure.

    For related coverage guidance, see recent payer policy updates: Onychomycosis diagnostic testing and coverage, Topical Acne-Non-Retinoid Products, Dermatology - Vtama Drug Quantity Management Policy - Per Days.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 62-year-old male with a history of squamous cell carcinoma of the bronchus undergoes diagnostic bronchoscopy for tissue staging. During the same session, the interventional pulmonologist administers a photosensitizing agent to an identified abnormal endobronchial lesion and performs photodynamic therapy to the lesion for a total exposure time within the 38–52 minute range, delivered in 15-minute increments as needed. The clinical workflow includes pre-procedure consent and photosensitizer dosing, endoscopic visualization and assessment of the lesion, instillation or topical application of the photosensitizing drug to the targeted abnormal tissue, timed light exposure using the appropriate wavelength for tissue penetration, intra-procedure monitoring for airway stability and oxygenation, and post-procedure recovery with instructions regarding photosensitivity precautions and follow-up surveillance bronchoscopy.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    31622Bronchoscopy, rigid or flexible, including fluoroscopic guidance, when performed; with diagnostic bronchoscopy with or without brushing or washingDiagnostic bronchoscopy is often performed immediately before PDT to visualize and sample lesions.
    43235Upper GI endoscopy including esophagus, stomach, and either the duodenum; diagnostic, including collection of specimen(s) by brushing or washingDiagnostic upper endoscopy may precede PDT for esophageal mucosal lesions.
    43239Esophagoscopy, rigid or flexible; with biopsy, single or multipleBiopsy during endoscopy provides histologic confirmation prior to photodynamic therapy.
    31624Bronchoscopy with biopsy, single or multipleTissue biopsy during bronchoscopy to confirm malignancy prior to or during the same session as PDT.
    51702Cystourethroscopy, with or without irrigation, instillation, or ureteral catheterization; diagnosticEndoscopic diagnostic procedures in other tracts are analogous when PDT is applied during a primary endoscopic session.
    96567Photodynamic therapy, including topical or systemic sensitizing agent, when performed without endoscopy (example for comparison)Related photodynamic therapy code used in non-endoscopic settings; illustrates alternative reporting for PDT when not performed with primary endoscopy/bronchoscopy.

    Related Modifiers

    11 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    73Modifier 73 indicates a facility-level outpatient hospital or ASC procedure that was discontinued after the patient was prepared and taken to the procedure/operating room but before any anesthesia…- When to use: Apply CPT modifier 73 on the FACILITY (outpatient hospital or ASC) claim when the patient has been fully prepared and physically taken into the procedure/operating room but the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…

    Showing 1–10 of 11

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207R00000XInternal Medicine PhysicianA physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults…
    2084P0800XPsychiatry PhysicianA Psychiatrist specializes in the prevention, diagnosis, and treatment of mental disorders, emotional disorders, psychotic disorders, mood disorders, …
    207T00000XNeurological Surgery PhysicianA neurological surgeon provides the operative and non-operative management (i.e., prevention, diagnosis, evaluation, treatment, critical care, and reh…
    208000000XPediatrics PhysicianA pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    213EG0000XDeactivated - Podiatrist
    364SR0400XRehabilitation Clinical Nurse SpecialistPhysician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist
    171W00000XContractorFor the purposes of the Health Care Provider Taxonomy, a contractor is limited to individuals who do construction or mechanical work to modify a patie…

    Related Payer Policy Updates

    Specialty: Dermatology1 / 2

    10 rows

    PolicyPayerEffective Date
    Onychomycosis diagnostic testing and coverageOscar Health2026-10-01
    Topical Acne-Non-Retinoid ProductsCigna2026-08-15
    Dermatology - Vtama Drug Quantity Management Policy - Per DaysCigna2026-08-15
    Medical Necessity Guidelines: Acne and Rosacea Medicationsharvard pilgrim health care2026-08-11
    Pharmacologic Treatment of PsoriasisPremera Bluecross2026-08-01
    Winlevi (clascoterone 1% cream) — Topical AcneCigna2026-08-01
    Spevigo (spesolimab‑sbzo) for generalized pustular psoriasisUnitedHealthcare2026-08-01
    Onychomycosis Testingblue cross blue shield - louisiana2026-08-01
    Spesolimab-sbzo (Spevigoblue cross blue shield - tennessee2026-07-31
    Home ultraviolet light therapy equipment for skin conditionsselect_health2026-07-01

    Related Codes

    CPT-96567-PHOTODYNAMIC-THERAPY-PRECANCEROUS-SKIN-LESION

    CPT 96567: Photodynamic Therapy for Precancerous Skin Lesions

    CPT-96570-PHOTODYNAMIC-THERAPY-DURING-ENDOSCOPY-BRONCHOSCOPY

    CPT 96570: Photodynamic Therapy During Endoscopy or Bronchoscopy

    CPT-96573-PHOTODYNAMIC-THERAPY-PHOTOSENSITIZER-APPLICATION-LESION

    CPT 96573: Photodynamic Therapy with Photosensitizer Application

    CPT-96574-PHOTODYNAMIC-THERAPY-FOR-PRECANCEROUS-SKIN-LESIONS

    CPT 96574: Photodynamic Therapy for Precancerous Skin Lesions

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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