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    v1.0.28
    OpenPayerBilling CodesPhotodynamic Therapy ProceduresCPT cpt-96574-photodynamic-therapy-for-precancerous-skin-lesions
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    CPT 96574: Photodynamic Therapy for Precancerous Skin Lesions

    Medicare pays $279 on average nationally for this procedure.

    CPT code 96574 describes physician- or qualified health professional–performed removal of hyperkeratotic precancerous skin lesions followed by photodynamic therapy that exposes a lesion treated with a photosensitizing drug to a specific wavelength of light; this dermatologic procedural service is typically delivered in an outpatient clinic, ambulatory surgery center, or dermatology office and is intended to destroy precancerous cells of the skin and adjacent mucosa and may be reported once per day.

    For related coverage guidance, see recent payer policy updates: Onychomycosis diagnostic testing and coverage, Topical Acne-Non-Retinoid Products, Dermatology - Vtama Drug Quantity Management Policy - Per Days.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 68-year-old male with a history of chronic sun exposure presents to a dermatology clinic with multiple hyperkeratotic, scaly patches on the dorsal hands and forearms diagnosed clinically and by shave biopsy as actinic keratoses with confluent areas suspicious for extensive field change. The physician applies a topical photosensitizing agent to the affected areas, waits the required incubation period, then performs photodynamic therapy (PDT) using a specific wavelength light source to activate the drug and destroy dysplastic keratinocytes. The procedure is performed in an outpatient dermatology procedure room under topical anesthesia; the patient is monitored briefly for pain and local reaction and discharged with wound care instructions and follow-up scheduled.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    11100Biopsy of single lesion, simple; skinPerformed prior to PDT when diagnostic confirmation is needed
    11101Biopsy of single lesion, intermediate; skinUsed if a deeper or more complex diagnostic sample is obtained before PDT
    17000Destruction (e.g., laser surgery) of premalignant lesions (e.g., actinic keratoses); first lesionAlternative or adjunctive destruction method for actinic keratoses in same visit
    17003Destruction of premalignant lesions, 14-25 lesionsWhen multiple lesions are destroyed by ablative methods instead of or before PDT
    99024Postoperative follow-up visit, routineUsed for routine postoperative follow-up visits after PDT when applicable

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207N00000XDermatology PhysicianA dermatologist is trained to diagnose and treat pediatric and adult patients with benign and malignant disorders of the skin, mouth, external genital…
    207P00000XEmergency Medicine PhysicianAn emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    163W00000XRegistered Nurse(1) A registered nurse is a person qualified by graduation from an accredited nursing school (depending upon schooling, a registered nurse may receive…
    163WC1600XContinuing Education/Staff Development Registered NurseNursing Service Providers · Registered Nurse
    2279E1000XEducational Registered Respiratory TherapistThe focus of patient and family education activities is to promote knowledge of disease process, medical therapy, and self help. Respiratory therapis…
    207YX0007XPlastic Surgery within the Head & Neck (Otolaryngology) PhysicianAn otolaryngologist with additional training in plastic and reconstructive procedures within the head, face, neck and associated structures, including…
    174H00000XHealth EducatorHealth educators work in a variety of settings providing education to individuals or groups of individuals on healthy behaviors, wellness, and health-…

    Related ICD-10-CM Codes

    24 rows

    ICD-10-CM CodeDescription
    B07.9Viral wart, unspecified
    C44.219Basal cell carcinoma of skin of left ear and external auricular canal
    C44.91Basal cell carcinoma of skin, unspecified
    D04.0Carcinoma in situ of skin of lip
    D04.9Carcinoma in situ of skin, unspecified
    D48.5Neoplasm of uncertain behavior of skin
    K13.0Diseases of lips
    K13.1Cheek and lip biting
    L20.9Atopic dermatitis, unspecified
    L30.9Dermatitis, unspecified

    Showing 1–10 of 24

    Related Payer Policy Updates

    Specialty: Dermatology1 / 2

    10 rows

    PolicyPayerEffective Date
    Onychomycosis diagnostic testing and coverageOscar Health2026-10-01
    Topical Acne-Non-Retinoid ProductsCigna2026-08-15
    Dermatology - Vtama Drug Quantity Management Policy - Per DaysCigna2026-08-15
    Medical Necessity Guidelines: Acne and Rosacea Medicationsharvard pilgrim health care2026-08-11
    Pharmacologic Treatment of PsoriasisPremera Bluecross2026-08-01
    Winlevi (clascoterone 1% cream) — Topical AcneCigna2026-08-01
    Spevigo (spesolimab‑sbzo) for generalized pustular psoriasisUnitedHealthcare2026-08-01
    Onychomycosis Testingblue cross blue shield - louisiana2026-08-01
    Spesolimab-sbzo (Spevigoblue cross blue shield - tennessee2026-07-31
    Home ultraviolet light therapy equipment for skin conditionsselect_health2026-07-01

    Related Codes

    CPT-96567-PHOTODYNAMIC-THERAPY-PRECANCEROUS-SKIN-LESION

    CPT 96567: Photodynamic Therapy for Precancerous Skin Lesions

    CPT-96570-PHOTODYNAMIC-THERAPY-DURING-ENDOSCOPY-BRONCHOSCOPY

    CPT 96570: Photodynamic Therapy During Endoscopy or Bronchoscopy

    CPT-96571-PHOTODYNAMIC-THERAPY-DURING-ENDOSCOPY-BRONCHOSCOPY

    CPT 96571: Photodynamic Therapy During Endoscopy or Bronchoscopy

    CPT-96573-PHOTODYNAMIC-THERAPY-PHOTOSENSITIZER-APPLICATION-LESION

    CPT 96573: Photodynamic Therapy with Photosensitizer Application

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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