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    v1.0.31
    OpenPayerBilling CodesVaccines, ToxoidsCPT cpt-90625-cholera-vaccine-oral-single-dose
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    CPT 90625: Cholera Vaccine, Single Oral Dose

    CPT code 90625 represents administration of a single-dose oral cholera vaccine given by a provider to treat or manage a patient with suspected cholera, an acute diarrheal illness caused by the bacterium Vibrio cholerae; service type: vaccine administration (oral), typical site of service: outpatient clinic or emergency department where oral vaccination is provided during evaluation or treatment for suspected infectious diarrhea.

    For related coverage guidance, see recent payer policy updates: Truvada (Emtricitabine and Tenofovir Disoproxil Fumarate) for HIV Prevention and Treatment, HIV/AIDS Pharmacologic Prevention and Treatment, Long-Acting Injectable Antiretroviral Agents for HIV.

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    Clinical & Coding Specifications

    Clinical Context

    A patient in an urgent care clinic presents with acute watery diarrhea, vomiting, and signs of moderate dehydration after recent travel to an area with active cholera transmission. Vital signs show tachycardia and orthostatic hypotension. The clinician performs a focused history and exam, collects stool culture or rapid testing if available, and initiates rehydration therapy (oral rehydration solution or IV fluids) as indicated. Given the clinical suspicion for cholera and the need for immediate protection and potential outbreak control, the provider administers a single-dose oral cholera vaccine using 90625. The vaccine is documented in the medical record, inclusion of lot number and expiration date is recorded, and observation for immediate adverse reaction occurs for the recommended period before discharge. Typical sites of service include urgent care centers, emergency departments, outpatient clinics, travel medicine clinics, and inpatient wards when post-exposure or during an outbreak investigation.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96372Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscularOften billed for injectable vaccines; not used for 90625 (oral), but included when co-administering an injectable vaccine during the same visit
    90471Immunization administration (includes percutaneous, intradermal, subcutaneous, or intramuscular) when performed; single vaccine/toxoidNot directly used for oral vaccine 90625; similar administration codes may be considered by some payors — documentation must support route and code selection
    90460Immunization administration through 18 years via any route; first component vaccineUsed for pediatric immunization encounters with counseling and administration; not typical for single-dose adult oral cholera vaccine but relevant if patient is a child and payor requires separate admin code
    36300Colony count or stool studies (example) [Note: placeholder for stool testing codes such as 87045]Diagnostic stool testing codes (e.g., stool culture 87045) are commonly ordered before or alongside treatment and public health reporting
    G0008Administration of influenza vaccine (Medicare)Example of a vaccine administration HCPCS; inclusion shows that administration reporting codes exist for payors though 90625 includes the vaccine product itself

    Note: If exact administration or immunization administration codes are required by a payer, separate billing may follow payer-specific rules; 90625 describes the oral cholera vaccine product administration as reported by the vaccine code itself.

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207P00000X
    207RG0300X
    363A00000X
    332B00000X
    174400000X
    2472V0600X
    103TR0400X
    207QA0505X

    Related ICD-10-CM Codes

    24 rows

    ICD-10-CM CodeDescription
    A00.0Cholera due to Vibrio cholerae 01, biovar cholerae
    A00.1Cholera due to Vibrio cholerae 01, biovar eltor
    A00.9Cholera, unspecified
    A02.0Salmonella enteritis
    A02.1Salmonella sepsis
    A02.9Salmonella infection, unspecified
    A04.0Enteropathogenic Escherichia coli infection
    A05.0Foodborne staphylococcal intoxication
    A05.9Bacterial foodborne intoxication, unspecified
    A07.1Giardiasis [lambliasis]

    Showing 1–10 of 24

    Related Payer Policy Updates

    Specialty: Infectious Disease1 / 3

    10 rows

    PolicyPayerEffective Date
    Truvada (Emtricitabine and Tenofovir Disoproxil Fumarate) for HIV Prevention and Treatmentpremerabluecrossofwashington2026-10-01
    HIV/AIDS Pharmacologic Prevention and Treatmentpremerabluecrossofwashington2026-10-01
    Long-Acting Injectable Antiretroviral Agents for HIVColorado Rocky Mountain Health Plans2026-10-01
    B-Hemolytic Streptococcus TestingOscar Health2026-10-01
    Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance AssaysOscar Health2026-10-01
    Hepatitis Testing (A, B, C, D) Coverage CriteriaOscar Health2026-10-01
    Lyme Disease Testing Coverage CriteriaOscar Health2026-10-01
    Pathogen Panel TestingOscar Health2026-10-01
    Diagnostic Testing of Common Sexually Transmitted InfectionsOscar Health2026-10-01
    Testing for Diagnosis of Active or Latent TuberculosisOscar Health2026-10-01

    Related Codes

    CPT-90476-ADENOVIRUS-TYPE-4-ORAL-VACCINE-ADMINISTRATION

    CPT 90476: Oral Live Vaccine for Adenovirus Type 4

    CPT-90477-ORAL-LIVE-ADENOVIRUS-TYPE-7-VACCINE

    CPT 90477: Oral Live Adenovirus Type 7 Vaccine Administration

    CPT-90581-ANTHRAX-VACCINE-INJECTION

    CPT 90581: Anthrax Vaccine, Injection

    CPT-90584-QUADRIVALENT-LIVE-DENGUE-VACCINE-SUBCUTANEOUS

    CPT 90584: Quadrivalent Live Dengue Vaccine, Subcutaneous, Two-Dose

    CPT-90585-TB-LIVE-INTRADERMAL-VACCINE

    CPT 90585: Live Tuberculosis Vaccine Administered Through the Skin

    CPT-90586-INTRAVESICAL-LIVE-VACCINE-BLADDER-CANCER

    CPT 90586: Intravesical Live Vaccine for Bladder Cancer

    CPT-90587-DENGUE-VACCINE-SUBCUTANEOUS-THREE-DOSE

    CPT 90587: Quadrivalent Live Dengue Vaccine, Subcutaneous, Three-Dose

    CPT-90589-CHIKUNGUNYA-VACCINE-INTRAMUSCULAR-LIVE-ATTENUATED

    CPT 90589: Chikungunya Vaccine, Live Attenuated, Intramuscular

    CPT-90593-RECOMBINANT-CHIKUNGUNYA-VACCINE-INTRAMUSCULAR

    CPT 90593: Recombinant Chikungunya Vaccine, Intramuscular

    CPT-90611-SMALLPOX-MONKEYPOX-VACCINE-SUBCUTANEOUS-05ML

    CPT 90611: Combined Smallpox and Monkeypox Vaccine, Subcutaneous 0.5 mL

    Showing 1–10 of 101

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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