CPT 90758: Live Intramuscular Vaccine for Zaire Ebolavirus

CPT code 90758 denotes a live intramuscular vaccine for protection against Zaire ebolavirus. As an Ebola vaccine code, it documents administration of a live-attenuated immunization typically provided in outpatient and public health clinic settings. Nationally, codes for emerging infectious disease vaccines carry importance for public health preparedness, tracking immunization uptake, and aligning coverage policies across major payers.

Key payers covered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of clinical context for 90758, typical sites of service, common modifiers and coding considerations, and the types of benchmarks and policy updates that inform payer coverage and claims processing. The publication summarizes coding practice implications for billing teams and revenue cycle staff, highlights areas where payer policies commonly differ, and outlines what documentation is typically needed to support claims for vaccine administration.

Where specific payer policy details or utilization benchmarks are not provided in the input, the text notes that those data are not available and focuses on the clinical and billing description of the vaccine code.

Billing Code Overview

CPT code 90758 represents a live vaccine product administered intramuscularly to protect against Zaire ebolavirus. This is a preventive immunization delivered as a live-attenuated vaccine designed to stimulate an immune response against Ebola virus disease caused by the Zaire ebolavirus species.

Service type: Vaccination / immunization (live vaccine)
Typical site of service: Outpatient clinic, public health clinic, vaccination center, or other ambulatory care settings where intramuscular vaccines are routinely administered.

Data not available in the input for associated taxonomies, ICD-10 diagnoses, and related codes.

Clinical Context

A 30-year-old laboratory research technician is scheduled to receive a live, intramuscular Ebola Zaire vaccine (90758) prior to beginning work in a high-containment viral research facility. The patient presents to an outpatient occupational health clinic for pre-employment immunization screening. The clinical workflow includes verification of immunization history and contraindications (pregnancy status, immunocompromise, allergy to vaccine components), informed consent discussion, and documentation of lot number and site of intramuscular administration (typically deltoid). Vital signs and a brief exam are completed to confirm fitness for vaccination. Post-vaccination, the patient is observed for 15–30 minutes for immediate adverse reactions; vaccine administration details and any patient education are recorded in the electronic medical record and the facility’s immunization registry. Billing uses 90758 for the live Zaire ebolavirus intramuscular vaccine; appropriate diagnosis pointers and any applicable modifiers are appended per payer requirements.

Coding Specifications

Modifier	Description	When to Use
`22`	Increased procedural services	Use when vaccine administration required substantially greater work or additional counseling beyond typical vaccine visit, documented in record.

Taxonomy Code	Specialty	Notes
363L00000X	Infectious Disease	Specialists who may order or oversee vaccine use for high-risk exposures.
207R00000X	Emergency Medicine	Emergency clinicians managing acute occupational exposures and initial vaccination.
208D00000X	Family Medicine	Common site for administering occupational and travel vaccines.
208000000X	Internal Medicine	Provide adult vaccinations in outpatient clinics.
364S00000X	Preventive Medicine	Occupational health and public health specialists overseeing immunization programs.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`Z20.828`	Contact with and (suspected) exposure to other viral communicable diseases	Used when documenting exposure risk warranting prophylactic vaccination for healthcare or laboratory personnel.
`Z29.8`	Encounter for other specified prophylactic measures	General code for encounters where prophylactic vaccination is provided.
`Z23`	Encounter for immunization	Primary encounter code for routine and occupational vaccinations, commonly used with vaccine administration.
`Z77.110`	Contact with and (suspected) exposure to antineoplastic drugs	Listed to illustrate exposure risk contexts; not specific to Ebola but used in occupational exposure reporting when relevant.
`Z71.89`	Other specified counseling	Use when significant vaccine counseling is provided and needs documentation; may support modifier `22` claims.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`90460`	Immunization administration through 18 years of age via any route of administration with counseling by physician or other qualified health care professional; first vaccine/toxoid component	If counseling at the same visit is billed separately for patients under 19, this administration code may be applicable; adult administrations use different administration codes.
`90461`	Each additional vaccine/toxoid component (List separately in addition to code for primary administration)	Use when multiple vaccine components are administered during the same visit and payer allows separate reporting.
`90471`	Immunization administration (single vaccine) intramuscular or subcutaneous, age 18 years or older; first vaccine/toxoid component	Commonly billed for adult intramuscular vaccine administration instead of vaccine product code when payer requires administration separate from product billing.
`90472`	Each additional vaccine (single or combination vaccine) administration by intramuscular or subcutaneous route, age 18 years or older	Use when more than one adult vaccine is administered at the same encounter.
`90474`	Immunization administration by intranasal or oral route; age 18 years or older	Included for workflow completeness if other non-intramuscular vaccines are given during the visit.

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Summary & Overview