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    v1.0.31
    OpenPayerBilling CodesImmune Globulins, Serum or Recombinant ProductsCPT cpt-90381-rsv-monoclonal-antibody-immunization-1ml
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    CPT 90381: RSV Monoclonal Antibody, Intramuscular Seasonal Dose

    CPT code 90381 describes a monoclonal antibody product administered intramuscularly as a seasonal 1 mL dose to provide passive protection against respiratory syncytial virus (RSV); service type is a preventive immunoprophylaxis injection and the typical site of service is an outpatient clinic or physician office for vaccine or biologic administration.

    For related coverage guidance, see recent payer policy updates: Bendamustine Products Coverage Criteria, T-Cell Lymphoma Agents: Beleodaq, Istodax, Lymphir, Poteligeo, and Romidepsin, Brentuximab Vedotin (Adcetris®) Coverage Criteria.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an infant or high-risk pediatric patient during RSV season who presents for preventive immunization against respiratory syncytial virus. The patient is scheduled for an outpatient vaccination visit in a pediatric clinic, primary care office, or hospital-based ambulatory clinic. The clinical workflow includes verification of patient identity and eligibility, review of indications and contraindications, informed parental consent, documentation of weight and medical history (including prematurity, chronic lung disease, congenital heart disease, or immunocompromise), preparation of the monoclonal antibody product (1 mL dose), intramuscular administration using age-appropriate technique, and post-administration observation for immediate adverse reactions (typically 15–30 minutes). Documentation in the medical record includes the product name, lot number, expiration date, route (intramuscular), dose (1 mL), date and time of administration, administering provider taxonomy, and any adverse events. Billing is submitted under 90381 with appropriate modifiers if required by the payer (for example, reporting an unrelated evaluation/management service on the same day) and with the applicable diagnosis code reflecting RSV prophylaxis indication.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    90460Immunization administration through 18 years of age, vaccine/toxoid component, with counseling by physician or other qualified health care professional; first vaccine/toxoid componentUsed when counseling and administration for immunoprophylaxis to a pediatric patient requires separate coding for vaccine administration with counseling.
    90461Each additional vaccine/toxoid component administered (use in conjunction with 90460)Used when multiple vaccine components are administered during the same visit in addition to 90381 prophylaxis.
    99070Supplies and materials (except spectacles), provided by the physician over and above those usually included with the office visitUsed if additional supplies for administration are billed separately by some payers.
    96372Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscularAlternative injection administration code used by some payers when billing for drug administration rather than vaccine-specific administration codes.
    99000Handling and/or conveyance of specimen for transfer from the physician's office to a laboratoryRarely applicable; included in workflow for documentation of specimens if needed for patient evaluation prior to prophylaxis.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    25CPT modifier 25 indicates that on the same day as another procedure or service, the same physician or other qualified health care professional provided a significant, separately identifiable…- When to apply: Use modifier 25 only on an E/M code to indicate the same provider delivered a significant, separately identifiable E/M service on the same day as another procedure or service — i.e.,…
    33Modifier 33 was created by the American Medical Association in response to the Affordable Care Act to identify services provided for preventive intent. It is appended to CPT/HCPCS codes that could be…- Use modifier -33 when a CPT/HCPCS service that can be billed as either preventive or diagnostic/treatment is provided with preventive intent and aligns with USPSTF A or B recommendations or other…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207Q00000X
    207RP1001X
    208000000X
    363A00000X
    261QR0206X
    207ZC0008X
    1710I1003X
    364SA2100X

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    10 rows

    PolicyPayerEffective Date
    Bendamustine Products Coverage Criteriablue cross blue shield - tennessee2027-01-30
    T-Cell Lymphoma Agents: Beleodaq, Istodax, Lymphir, Poteligeo, and RomidepsinMass General Brigham Health Plan2027-01-04
    Brentuximab Vedotin (Adcetris®) Coverage Criteriablue cross blue shield - tennessee2026-12-31
    Pemetrexed Coverageblue cross blue shield - tennessee2026-12-31
    Tumor Treatment Fields - Medical PolicyHealth-New-England2026-12-01
    Extracorporeal PhotopheresisCigna2026-11-15
    VonvendiCigna2026-11-15
    Hematology - AphexdaCigna2026-11-15
    Extracorporeal PhotopheresisCigna2026-11-15
    Yartemlea (narsoplimab-wuug) Coverage for TA-TMANeighborhood Health Plan of Rhode Island2026-11-01

    Related Codes

    CPT-90281-IMMUNOGLOBULIN-THERAPY-INFUSION

    CPT 90281: Immunoglobulin for Passive Immunity

    CPT-90283-IMMUNOGLOBULIN-PASSIVE-IMMUNITY

    CPT 90283: Immunoglobulin for Passive Immunity

    CPT-90284-SUBCUTANEOUS-IMMUNOGLOBULIN-INJECTION-SCIG-IGSC

    CPT 90284: Subcutaneous Immunoglobulin (SCIg) Injection

    CPT-90287-BOTULISM-ANTITOXIN-EQUINE-GLOBULIN

    CPT 90287: Botulism Antitoxin (Equine Globulin)

    CPT-90288-BOTULISM-IMMUNE-GLOBULIN-INTRAVENOUS

    CPT 90288: Botulism Immune Globulin Intravenous Administration

    CPT-90291-CMV-IMMUNE-GLOBULIN-INTRAVENOUS-INFUSION

    CPT 90291: Cytomegalovirus Immune Globulin (CMV–IgIV) Administration

    CPT-90296-DIPHTHERIA-ANTITOXIN-EQUINE

    CPT 90296: Diphtheria Antitoxin (Equine) Administration

    CPT-90371-HEPATITIS-B-IMMUNOGLOBULIN-HBIG

    CPT 90371: Hepatitis B Immunoglobulin (HBIg) Injection

    CPT-90375-RABIES-IMMUNOGLOBULIN-PASSIVE-IMMUNITY

    CPT 90375: Human Rabies Immunoglobulin for Passive Immunity

    CPT-90376-RABIES-IMMUNOGLOBULIN-HUMAN-POST-EXPOSURE-PROPHYLAXIS

    CPT 90376: Human Rabies Immunoglobulin for Passive Immunity

    Showing 1–10 of 21

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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