Loading...

    Explore
    • Policy Monitoring
    • Live Policy Feed
    • Billing Codes
    • NPI Medicare & Medicaid
    • Healthcare Providers
    • Health Insurance Payers
    • States
    • Service Lines
    • Taxonomy Codes
    Lookup tools
    • Billing Code Lookup
    • CPT Modifier Lookup
    • Provider Taxonomy Code Lookup
    • Healthcare Provider & Facility Lookup
    • Health Insurance Payer Lookup
    • Payer Contact Directory

    Policy & Benchmark Tools

    • Prior Authorization Lookup
    • Coverage Criteria Lookup
    • Timely Filing Lookup
    • Billing Code Reimbursement Rates
    • Payer Comparison Dashboard
    • Facility Comparison Dashboard
    • All tools

    Company

    • About OpenPayer
    • Data Sources
    • Trek Health
    OpenPayerby Trek Health
    LinkedInYouTube

    © 2026 Trek Health. All rights reserved.

    OpenPayer is built and maintained by Trek Health.

    v1.0.30
    OpenPayerBilling CodesCytopathology Screening ProceduresCPT cpt-88160-cytopathology-smear-technical-analysis
    Ask Trek AI about this page

    CPT 88160: Cytopathology Smear Screening and Interpretation

    Medicare pays $57 on average nationally for this procedure.

    CPT code 88160 describes a laboratory cytopathology smear procedure in which a laboratory analyst performs the technical analysis and screening interpretation of a cytologic smear when no more specific cytology code applies; this service is a cytopathology screening and interpretation procedure typically performed as a clinical laboratory service and is most often provided in hospital or outpatient laboratory settings for specimens such as cervical, vaginal, fine-needle aspirates, body fluids, and washings.

    For related coverage guidance, see recent payer policy updates: General Inflammation Testing, Urine Culture Testing for Bacteria, Biomarkers for Myocardial Infarction and Chronic Heart Failure.

    Customize your policy alerts

    Sign up for cpt 88160 policy alerts

    Get alerted when payer policies referencing 88160 are released or updated.

    Monitor payer policy activity

    Receive email alerts as soon as relevant payer policies are published or updated.

    Table of contents

    Progress1 / 6

    Explore openpayer tools

    • Billing CodesCPT, HCPCS, DRG & more
    • Reimbursement RatesCommercial vs. Medicare rate reports
    • Facility ComparisonBeds, revenue & payer mix
    • ProvidersHospitals & facilities
    • PayersPlans & market footprint
    • Taxonomy CodesNUCC specialty codes
    • ModifiersCPT modifiers & usage
    • Prior AuthorizationPA policies by payer & drug
    • Timely FilingFiling deadlines by payer
    • Coverage CriteriaMedical necessity by payer
    • Payer ContactsClaims, PA & appeals contacts
    View all tools

    Clinical & Coding Specifications

    Clinical Context

    A 48-year-old outpatient presents for evaluation of a suspicious cytologic specimen obtained from a non-cervical site (for example, a pleural fluid smear sent from the emergency department). The specimen arrives in the clinical laboratory labeled with patient identifiers and requisition documentation. A histology or cytology technician prepares and stains the smear. A laboratory analyst performs the technical analysis of the cytopathology smear under a microscope to screen for abnormal cells, document adequacy, and select fields for photomicrography if required. The analyst records findings and forwards the prepared slide and preliminary technical report to a board-certified pathologist for final interpretation. The laboratory bills the technical component for the screening/analysis of the cytology smear using 88160 only if no more specific cytopathology screening code (for cervical, vaginal, fine needle aspirates, body fluids, washings, etc.) applies. Typical coordination involves specimen accessioning, slide preparation, staining, microscopic screening, and transmission of slides and technical notes to the interpreting physician. Typical sites of service include hospital outpatient laboratories, independent clinical laboratories, ambulatory surgery centers handling specimen submissions, and emergency department laboratory services.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    88164Cytopathology, smears, requiring interpretation by physician (may include digital imaging), per specimenPhysician interpretation code commonly billed by pathologists after technical screening under 88160 when a more specific cytology interpretation code applies.
    88175Cytopathology, automated thin layer preparation and screening, by laboratory personnel; screening onlyAlternative technical screening method used for fluid or smear preparations; may be billed when thin-layer processing is used instead of manual smear screening.
    88173Cytopathology, automated thin layer preparation and interpretation, by a laboratoryRelated when thin-layer technology is used and both technical and interpretation components differ from manual smear codes.
    88305Level IV surgical pathology, gross and microscopic examinationMay be billed when cytologic smear findings prompt concurrent tissue biopsy processing and histologic correlation.
    88141Cytopathology, cervical or vaginal cytologic smears; requiring interpretation by a physician, per specimenA specific cervical/vaginal screening code that, if applicable, should be used instead of 88160 per code guidance.
    88142Cytopathology, cervical or vaginal smears; automated review, screening and preparationSpecific automated cervical/vaginal cytology code used when applicable and preferred over the nonspecific 88160.

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207R00000X
    207L00000X
    363A00000X
    122400000X
    283XC2000X
    2080T0004X
    364SE0003X
    292200000X

    Related Payer Policy Updates

    Specialty: Laboratory/Pathology1 / 3

    10 rows

    PolicyPayerEffective Date
    General Inflammation TestingOscar Health2027-01-01
    Urine Culture Testing for BacteriaOscar Health2027-01-01
    Biomarkers for Myocardial Infarction and Chronic Heart FailureOscar Health2027-01-01
    Policy Regarding Outpatient Definitive Drug TestingMolina Healthcare2027-01-01
    Serum Testing for Evidence of Mild Traumatic Brain InjuryHealthfirst2026-11-01
    Respiratory Viral PanelsProvidence Health Plan2026-10-01
    Serum Iron StudiesProvidence Health Plan2026-10-01
    Prothrombin Time (PT)Providence Health Plan2026-10-01
    Partial Thromboplastin Time (PTT)Providence Health Plan2026-10-01
    Respiratory Viral PanelsProvidence Health Plan2026-10-01

    Related Codes

    CPT-88141-CERVICAL-VAGINAL-CYTOPATHOLOGY-INTERPRETATION

    CPT 88141: Cervical or Vaginal Cytopathology Interpretation

    CPT-88142-THIN-LAYER-CYTOLOGY-MANUAL-SCREENING

    CPT 88142: Thin-Layer Cervical/Vaginal Cytology, Automated Prep with Manual Screening

    CPT-88143-THIN-LAYER-CYTOLOGY-MANUAL-SCREENING

    CPT 88143: Thin-Layer Cervical/Vaginal Cytology, Automated Prep with Manual Screening

    CPT-88147-AUTOMATED-CERVICAL-VAGINAL-CYTOPATHOLOGY-SCREENING

    CPT 88147: Automated Cervical/Vaginal Cytology Screening, Technical

    CPT-88148-CYTOPATHOLOGY-AUTOMATED-SCREEN-MANUAL-RESCREEN

    CPT 88148: Automated Cervical/Vaginal Cytology Screen with Manual Rescreening

    CPT-88150-CERVICAL-VAGINAL-CYTOPATHOLOGY-SLIDE-ANALYSIS

    CPT 88150: Manual Cervical or Vaginal Cytopathology Technical Analysis

    CPT-88152-CERVICAL-VAGINAL-CYTOPATHOLOGY-COMPUTER-ASSISTED-RESCREEN

    CPT 88152: Cervical/Vaginal Cytopathology Manual Technical with Computer-Assisted Rescreening

    CPT-88153-CERVICAL-VAGINAL-CYTOPATHOLOGY-MANUAL-RESCREENING

    CPT 88153: Manual Rescreen of Cervical or Vaginal Cytology Slide

    CPT-88155-CERVICOVAGINAL-CYTOPATHOLOGY-HORMONE-EVALUATION

    CPT 88155: Cervicovaginal Cytopathology Hormone Evaluation

    CPT-88161-CYTOPATHOLOGY-SMEAR-TECHNICAL-SCREENING

    CPT 88161: Cytopathology Smear Screening and Technical Analysis

    Showing 1–10 of 15

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
    Published by

    Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

    Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.