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    v1.0.30
    OpenPayerBilling CodesCytopathology Screening ProceduresCPT cpt-88153-cervical-vaginal-cytopathology-manual-rescreening
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    CPT 88153: Manual Rescreen of Cervical or Vaginal Cytology Slide

    CPT code 88153 describes a laboratory service in which a lab analyst manually performs a cervical or vaginal cytopathology slide evaluation (technical component) and then manually rescreens the same slide under physician supervision; service type: manual cytopathology rescreen, typical site of service: clinical laboratory or hospital laboratory.

    For related coverage guidance, see recent payer policy updates: General Inflammation Testing, Urine Culture Testing for Bacteria, Biomarkers for Myocardial Infarction and Chronic Heart Failure.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 35-year-old woman presents for routine cervical cancer screening after a pelvic exam performed by her primary care clinician. A clinician collects a cervical cytology specimen (Pap smear) and submits the slide to an outpatient clinical laboratory. A cytology technologist (lab analyst) performs a manual microscopic evaluation of the cervical slide, documents findings, and then performs a second, independent manual rescreen of the same slide under the supervising pathologist's direction to ensure quality and detection of rare abnormal cells. The supervising pathologist reviews any flagged or abnormal findings and signs the final report. Typical sites of service include hospital-based pathology laboratories, independent clinical pathology labs, and large outpatient diagnostic laboratories supporting ambulatory clinics.

    • Service Type: Laboratory technical cytology service with manual rescreening of a cervical or vaginal cytopathology slide.

    • Typical Site of Service: Hospital clinical laboratory, independent diagnostic laboratory, outpatient pathology laboratory.

    • Typical Patient Scenario: Asymptomatic screening or follow-up of prior abnormal cytology; specimen processed manually due to slide quality or when automated screening is not available or when a quality-control rescreen is required. The lab analyst documents results and escalates abnormal or indeterminate findings for physician review.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    88152Cytopathology, cervical or vaginal (Pap), smear; requiring interpretation by physician with manual screening by technologist (first review)Often billed for the initial manual screening step when a technologist performs the primary review prior to rescreening; 88153 represents the rescreening by the technologist.
    88164Cytopathology, cervical or vaginal (Pap), requiring interpretation by physician with automated screening, and manual rescreening by technologistRelated when automated primary screening is used; 88164 covers automated screen with manual rescreen, whereas 88153 covers manual rescreen following a manual initial screen.
    88141Cytopathology, cervical or vaginal (Pap), requiring interpretation by a physician, single smear; physician interpretation without technologist rescreenRepresents the physician-only interpretation option when technologist screening/rescreening is not performed.
    88150Cytopathology, cervical or vaginal (Pap), screening by automated system, unlisted if manual rescreen not requiredUsed in workflows that begin with automated screening rather than manual; helps differentiate method used.
    88174

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208000000X
    363L00000X
    364SC0200X
    261QP0904X
    2083A0100X
    2084P0802X
    261QM1000X
    261QS0112X

    Related ICD-10-CM Codes

    27 rows

    ICD-10-CM CodeDescription
    C53.1Malignant neoplasm of exocervix
    C53.9Malignant neoplasm of cervix uteri, unspecified
    D06.9Carcinoma in situ of cervix, unspecified
    N76.0Acute vaginitis
    N76.1Subacute and chronic vaginitis
    N76.2Acute vulvitis
    N87.0Mild cervical dysplasia
    N87.1Moderate cervical dysplasia
    N87.9Dysplasia of cervix uteri, unspecified
    N89.0Mild vaginal dysplasia

    Showing 1–10 of 27

    Related Payer Policy Updates

    Specialty: Laboratory/Pathology1 / 3

    10 rows

    PolicyPayerEffective Date
    General Inflammation TestingOscar Health2027-01-01
    Urine Culture Testing for BacteriaOscar Health2027-01-01
    Biomarkers for Myocardial Infarction and Chronic Heart FailureOscar Health2027-01-01
    Policy Regarding Outpatient Definitive Drug TestingMolina Healthcare2027-01-01
    Serum Testing for Evidence of Mild Traumatic Brain InjuryHealthfirst2026-11-01
    Respiratory Viral PanelsProvidence Health Plan2026-10-01
    Serum Iron StudiesProvidence Health Plan2026-10-01
    Prothrombin Time (PT)Providence Health Plan2026-10-01
    Partial Thromboplastin Time (PTT)Providence Health Plan2026-10-01
    Respiratory Viral PanelsProvidence Health Plan2026-10-01

    Related Codes

    CPT-88141-CERVICAL-VAGINAL-CYTOPATHOLOGY-INTERPRETATION

    CPT 88141: Cervical or Vaginal Cytopathology Interpretation

    CPT-88142-THIN-LAYER-CYTOLOGY-MANUAL-SCREENING

    CPT 88142: Thin-Layer Cervical/Vaginal Cytology, Automated Prep with Manual Screening

    CPT-88143-THIN-LAYER-CYTOLOGY-MANUAL-SCREENING

    CPT 88143: Thin-Layer Cervical/Vaginal Cytology, Automated Prep with Manual Screening

    CPT-88147-AUTOMATED-CERVICAL-VAGINAL-CYTOPATHOLOGY-SCREENING

    CPT 88147: Automated Cervical/Vaginal Cytology Screening, Technical

    CPT-88148-CYTOPATHOLOGY-AUTOMATED-SCREEN-MANUAL-RESCREEN

    CPT 88148: Automated Cervical/Vaginal Cytology Screen with Manual Rescreening

    CPT-88150-CERVICAL-VAGINAL-CYTOPATHOLOGY-SLIDE-ANALYSIS

    CPT 88150: Manual Cervical or Vaginal Cytopathology Technical Analysis

    CPT-88152-CERVICAL-VAGINAL-CYTOPATHOLOGY-COMPUTER-ASSISTED-RESCREEN

    CPT 88152: Cervical/Vaginal Cytopathology Manual Technical with Computer-Assisted Rescreening

    CPT-88155-CERVICOVAGINAL-CYTOPATHOLOGY-HORMONE-EVALUATION

    CPT 88155: Cervicovaginal Cytopathology Hormone Evaluation

    CPT-88160-CYTOPATHOLOGY-SMEAR-TECHNICAL-ANALYSIS

    CPT 88160: Cytopathology Smear Screening and Interpretation

    CPT-88161-CYTOPATHOLOGY-SMEAR-TECHNICAL-SCREENING

    CPT 88161: Cytopathology Smear Screening and Technical Analysis

    Showing 1–10 of 15

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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    Cytopathology, slides prepared and sent for review; ancillary CPT for review of non-gynecologic cytology
    May be used for additional slide preparations or consultations in complex cytology cases following initial and rescreening steps.