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    v1.0.30
    OpenPayerBilling CodesCytopathology Screening ProceduresCPT cpt-88148-cytopathology-automated-screen-manual-rescreen
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    CPT 88148: Automated Cervical/Vaginal Cytology Screen with Manual Rescreening

    CPT code 88148 describes a technical laboratory service in which a lab analyst performs an automated screening of a cervical or vaginal cytopathology smear followed by a manual rescreening under a supervising physician; the service is a cytopathology screening procedure typically performed in a clinical laboratory or pathology lab setting and reported when automated review with subsequent manual review of the specimen is completed.

    For related coverage guidance, see recent payer policy updates: General Inflammation Testing, Urine Culture Testing for Bacteria, Biomarkers for Myocardial Infarction and Chronic Heart Failure.

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    Clinical & Coding Specifications

    Clinical Context

    A 34-year-old patient presents to a gynecology clinic for routine cervical cancer screening. A pelvic exam is performed and a cervical cytology (Pap) specimen is collected using a cervical brush and liquid-based cytology vial. The specimen is sent to a centralized cytology laboratory. The lab analyst performs an automated primary screening of the cervical/vaginal cytology smear using an FDA-cleared automated screening system, flagging any slides requiring review. The analyst then performs a manual rescreen of flagged or high-risk slides under the supervision of a pathologist. The physician provides final review and signs the report. Typical sites of service include outpatient gynecology clinics, ambulatory surgical centers, and independent clinical laboratories. Common clinical indications include routine screening, follow-up of an abnormal prior Pap, post-treatment surveillance, or evaluation of abnormal bleeding.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    88142Cytopathology, cervical or vaginal (eg, Pap) smears, interpretation by physician; manual screening and interpretation.Ancillary or alternative service when manual screening/interpretation is performed without automated primary screening; may be billed when manual-only workflow is used.
    88175Cytopathology, cervical or vaginal (eg, Pap) smears, automated screening and interpretation, with manual review of abnormal slides performed by a physician.Closely related automated screening code typically used when the physician performs automated review with manual review; may be reported in workflows where physician rather than lab analyst performs review.
    88164Cytopathology, cervical or vaginal (eg, Pap) smears, collection and transport only; unspecified.Relevant for documentation of specimen collection services performed by the clinician prior to lab-based automated screening/rescreening.
    88147Cytopathology, cervical or vaginal (eg, Pap) smears, automated screening with manual rescreening by a technologist, under physician supervision (technical component).Component code for technical automated screen/rescreen performed by lab personnel; often billed by laboratories performing the technical service.
    88148Cytopathology, cervical or vaginal (eg, Pap) smears, automated screening with manual rescreening by a technologist, under physician supervision (analyst-performed service).Primary code for the laboratory analyst performing the automated screen followed by manual rescreening under physician supervision; represents the technical screening workflow.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207Q00000X
    207L00000X
    363A00000X
    207K00000X
    208M00000X
    261QM1101X
    2080C0008X
    207QA0505X

    Related Payer Policy Updates

    Specialty: Laboratory/Pathology1 / 3

    10 rows

    PolicyPayerEffective Date
    General Inflammation TestingOscar Health2027-01-01
    Urine Culture Testing for BacteriaOscar Health2027-01-01
    Biomarkers for Myocardial Infarction and Chronic Heart FailureOscar Health2027-01-01
    Policy Regarding Outpatient Definitive Drug TestingMolina Healthcare2027-01-01
    Serum Testing for Evidence of Mild Traumatic Brain InjuryHealthfirst2026-11-01
    Respiratory Viral PanelsProvidence Health Plan2026-10-01
    Serum Iron StudiesProvidence Health Plan2026-10-01
    Prothrombin Time (PT)Providence Health Plan2026-10-01
    Partial Thromboplastin Time (PTT)Providence Health Plan2026-10-01
    Respiratory Viral PanelsProvidence Health Plan2026-10-01

    Related Codes

    CPT-88141-CERVICAL-VAGINAL-CYTOPATHOLOGY-INTERPRETATION

    CPT 88141: Cervical or Vaginal Cytopathology Interpretation

    CPT-88142-THIN-LAYER-CYTOLOGY-MANUAL-SCREENING

    CPT 88142: Thin-Layer Cervical/Vaginal Cytology, Automated Prep with Manual Screening

    CPT-88143-THIN-LAYER-CYTOLOGY-MANUAL-SCREENING

    CPT 88143: Thin-Layer Cervical/Vaginal Cytology, Automated Prep with Manual Screening

    CPT-88147-AUTOMATED-CERVICAL-VAGINAL-CYTOPATHOLOGY-SCREENING

    CPT 88147: Automated Cervical/Vaginal Cytology Screening, Technical

    CPT-88150-CERVICAL-VAGINAL-CYTOPATHOLOGY-SLIDE-ANALYSIS

    CPT 88150: Manual Cervical or Vaginal Cytopathology Technical Analysis

    CPT-88152-CERVICAL-VAGINAL-CYTOPATHOLOGY-COMPUTER-ASSISTED-RESCREEN

    CPT 88152: Cervical/Vaginal Cytopathology Manual Technical with Computer-Assisted Rescreening

    CPT-88153-CERVICAL-VAGINAL-CYTOPATHOLOGY-MANUAL-RESCREENING

    CPT 88153: Manual Rescreen of Cervical or Vaginal Cytology Slide

    CPT-88155-CERVICOVAGINAL-CYTOPATHOLOGY-HORMONE-EVALUATION

    CPT 88155: Cervicovaginal Cytopathology Hormone Evaluation

    CPT-88160-CYTOPATHOLOGY-SMEAR-TECHNICAL-ANALYSIS

    CPT 88160: Cytopathology Smear Screening and Interpretation

    CPT-88161-CYTOPATHOLOGY-SMEAR-TECHNICAL-SCREENING

    CPT 88161: Cytopathology Smear Screening and Technical Analysis

    Showing 1–10 of 15

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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