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    v1.0.30
    OpenPayerBilling CodesCytopathology Screening ProceduresCPT cpt-88143-thin-layer-cytology-manual-screening
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    CPT 88143: Thin-Layer Cervical/Vaginal Cytology, Automated Prep with Manual Screening

    CPT code 88143 describes a laboratory service in which a lab analyst performs the technical processing of a cervical or vaginal cytology specimen collected in preservative fluid using an automated thin-layer preparation, followed by manual screening and rescreening under a physician’s supervision; service type: laboratory cytopathology technical component with manual screening; typical site of service: outpatient laboratory or hospital clinical laboratory processing specimens collected in clinic or office settings.

    For related coverage guidance, see recent payer policy updates: General Inflammation Testing, Urine Culture Testing for Bacteria, Biomarkers for Myocardial Infarction and Chronic Heart Failure.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 32-year-old patient presents to a gynecology clinic for routine cervical cancer screening. The clinician obtains a liquid-based cervical cytology specimen (ThinPrep or similar) placed into preservative fluid during a speculum exam. The specimen is sent to the laboratory where a cytotechnologist performs an automated thin-layer preparation followed by manual screening and rescreening under a supervising pathologist’s oversight. Results are reported using a cytology reporting system (for example, Bethesda). Typical workflow includes specimen accessioning, automated slide preparation, primary manual screening by a cytotechnologist, rescreening for quality control or abnormalities, and final review/oversight by a physician. Typical site of service is an outpatient clinic, physician office, or independent clinical laboratory. The service is performed for routine screening, evaluation of abnormal bleeding, follow-up of prior abnormal cytology, or reflex testing per clinical guidelines.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    88142Cytopathology, cervical or vaginal (any reporting system), requiring interpretation by a physician, with manual screening of a smear or thin layer preparation when performed; technician prepares and the physician performs interpretationPerformed when a physician interprets the prepared cytology specimen rather than a laboratory technician alone; often billed in conjunction with or as alternative to 88143 when only the physician interpretation is reported.
    88175Cytopathology, cervical or vaginal; automated screening with manual rescreening under physician supervision (computer assisted)Commonly paired when automated screening platforms are used and additional manual rescreening or computer-assisted analysis is performed.
    88164Cytopathology, cervical or vaginal; automated thin layer preparation, preceded by manual screening by a technician with physician review (if applicable)Used for specific thin-layer prep workflows where a different billing structure or level of interpretation applies.
    88141Cytopathology, cervical or vaginal; screening only, by technician (without physician interpretation)Used when the laboratory performs only technician screening without physician oversight; may precede or follow processes that result in 88143 when supervisory review is added.
    88148Cytopathology, any site; cell block and separate cytologic interpretationPerformed when additional cell block preparation and interpretation are required after initial cytology screening.
    88174Cytopathology, cervical or vaginal; ancillary testing for high-risk HPV (when performed in conjunction)Frequently ordered reflexively for abnormal cytology results; may be reported alongside cytology codes when both tests are processed.

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RH0000X
    208000000X
    363LF0000X
    207K00000X
    246QI0000X
    2278S1500X
    261QX0200X
    364ST0500X

    Related Payer Policy Updates

    Specialty: Laboratory/Pathology1 / 3

    10 rows

    PolicyPayerEffective Date
    General Inflammation TestingOscar Health2027-01-01
    Urine Culture Testing for BacteriaOscar Health2027-01-01
    Biomarkers for Myocardial Infarction and Chronic Heart FailureOscar Health2027-01-01
    Policy Regarding Outpatient Definitive Drug TestingMolina Healthcare2027-01-01
    Serum Testing for Evidence of Mild Traumatic Brain InjuryHealthfirst2026-11-01
    Respiratory Viral PanelsProvidence Health Plan2026-10-01
    Serum Iron StudiesProvidence Health Plan2026-10-01
    Prothrombin Time (PT)Providence Health Plan2026-10-01
    Partial Thromboplastin Time (PTT)Providence Health Plan2026-10-01
    Respiratory Viral PanelsProvidence Health Plan2026-10-01

    Related Codes

    CPT-88141-CERVICAL-VAGINAL-CYTOPATHOLOGY-INTERPRETATION

    CPT 88141: Cervical or Vaginal Cytopathology Interpretation

    CPT-88142-THIN-LAYER-CYTOLOGY-MANUAL-SCREENING

    CPT 88142: Thin-Layer Cervical/Vaginal Cytology, Automated Prep with Manual Screening

    CPT-88147-AUTOMATED-CERVICAL-VAGINAL-CYTOPATHOLOGY-SCREENING

    CPT 88147: Automated Cervical/Vaginal Cytology Screening, Technical

    CPT-88148-CYTOPATHOLOGY-AUTOMATED-SCREEN-MANUAL-RESCREEN

    CPT 88148: Automated Cervical/Vaginal Cytology Screen with Manual Rescreening

    CPT-88150-CERVICAL-VAGINAL-CYTOPATHOLOGY-SLIDE-ANALYSIS

    CPT 88150: Manual Cervical or Vaginal Cytopathology Technical Analysis

    CPT-88152-CERVICAL-VAGINAL-CYTOPATHOLOGY-COMPUTER-ASSISTED-RESCREEN

    CPT 88152: Cervical/Vaginal Cytopathology Manual Technical with Computer-Assisted Rescreening

    CPT-88153-CERVICAL-VAGINAL-CYTOPATHOLOGY-MANUAL-RESCREENING

    CPT 88153: Manual Rescreen of Cervical or Vaginal Cytology Slide

    CPT-88155-CERVICOVAGINAL-CYTOPATHOLOGY-HORMONE-EVALUATION

    CPT 88155: Cervicovaginal Cytopathology Hormone Evaluation

    CPT-88160-CYTOPATHOLOGY-SMEAR-TECHNICAL-ANALYSIS

    CPT 88160: Cytopathology Smear Screening and Interpretation

    CPT-88161-CYTOPATHOLOGY-SMEAR-TECHNICAL-SCREENING

    CPT 88161: Cytopathology Smear Screening and Technical Analysis

    Showing 1–10 of 15

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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