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    v1.0.30
    OpenPayerBilling CodesPostmortem Examination ProceduresCPT cpt-88025-autopsy-with-brain-examination-technical
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    CPT 88025: Autopsy with Gross and Microscopic Examination Including Brain

    CPT code 88025 describes the technical performance of an autopsy including gross and microscopic examination of the body with examination of the brain; the service is a postmortem pathological examination and is typically provided as a facility-based pathology service in a hospital morgue, medical examiner’s office, or pathology laboratory setting.

    For related coverage guidance, see recent payer policy updates: General Inflammation Testing, Urine Culture Testing for Bacteria, Biomarkers for Myocardial Infarction and Chronic Heart Failure.

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    Clinical & Coding Specifications

    Clinical Context

    A decedent is received in the hospital pathology suite following an in-hospital death where the cause of death is unclear or medicolegal evaluation is requested. The pathologist’s team performs a complete autopsy that includes external examination, internal gross dissection, and systematic microscopic sampling of organs including the brain. The typical workflow: notification and consent or legal authorization obtained; body identification and chain-of-custody documented; external examination and photographic documentation; evisceration and organ block removal; in situ and gross examination of thoracic, abdominal, pelvic organs and cranium; brain removal and fixation, gross and microscopic brain examination; submission of tissue blocks for histology; interpretation and compilation of the autopsy report including immediate cause, contributing conditions, and clinicopathologic correlation. Typical site of service: hospital pathology department, medical examiner/coroner facility, or anatomic pathology department within an accredited hospital. Typical patient scenario: an adult inpatient with sudden, unexplained cardiopulmonary collapse where diagnostic uncertainty remains after clinical evaluation and imaging, and an autopsy including brain examination is ordered to determine cause of death and to provide information for family counseling and quality improvement.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    88016Gross and microscopic examination of placenta and fetal membranesPerformed when perinatal death or pregnancy-related factors are part of the autopsy evaluation
    88104Cytopathology, cervical or vaginal (non-gynecologic uses) — microscopic examinationMay be performed on ancillary cytology specimens submitted during postmortem evaluation when indicated
    88305Level IV pathology, surgical pathology, gross and microscopic examinationUsed for individual organ or tissue histopathology specimens submitted during an autopsy for additional detailed analysis
    88342Immunohistochemistry, per single antibody stainPerformed on autopsy tissue blocks when immunostains are required to establish diagnosis
    88331Consultation and review of slides by an outside pathologistUsed when external slide consultation or second opinion is obtained for autopsy findings
    99490Chronic care management (non-face-to-face)Not typically billed for autopsy, included here only if administrative follow-up with family or quality review services are separately billable under specific payer guidance

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207R00000X
    208000000X
    207RP1001X
    207L00000X
    317400000X
    163WC3500X
    173F00000X
    163WC0400X

    Related ICD-10-CM Codes

    28 rows

    ICD-10-CM CodeDescription
    A02.1Salmonella sepsis
    A41.9Sepsis, unspecified organism
    B20Human immunodeficiency virus [HIV] disease
    C34.90Malignant neoplasm of unspecified part of unspecified bronchus or lung
    C71.9Malignant neoplasm of brain, unspecified
    E10.65Type 1 diabetes mellitus with hyperglycemia
    E11.9Type 2 diabetes mellitus without complications
    F03.90Unspecified dementia, unspecified severity, without behavioral disturbance, psychotic disturbance, mood disturbance, and anxiety
    G30.9Alzheimer's disease, unspecified
    G45.9Transient cerebral ischemic attack, unspecified

    Showing 1–10 of 28

    Related Payer Policy Updates

    Specialty: Laboratory/Pathology1 / 2

    10 rows

    PolicyPayerEffective Date
    General Inflammation TestingOscar Health2027-01-01
    Urine Culture Testing for BacteriaOscar Health2027-01-01
    Biomarkers for Myocardial Infarction and Chronic Heart FailureOscar Health2027-01-01
    Policy Regarding Outpatient Definitive Drug TestingMolina Healthcare2027-01-01
    Serum Testing for Evidence of Mild Traumatic Brain InjuryHealthfirst2026-11-01
    Respiratory Viral PanelsProvidence Health Plan2026-10-01
    Serum Iron StudiesProvidence Health Plan2026-10-01
    Prothrombin Time (PT)Providence Health Plan2026-10-01
    Partial Thromboplastin Time (PTT)Providence Health Plan2026-10-01
    Respiratory Viral PanelsProvidence Health Plan2026-10-01

    Related Codes

    CPT-88000-POSTMORTEM-GROSS-EXAMINATION-EXTERNAL-ONLY

    CPT 88000: Postmortem External Examination

    CPT-88005-GROSS-POSTMORTEM-EXAMINATION-WITH-BRAIN

    CPT 88005: Gross Postmortem Examination Including Brain

    CPT-88007-POSTMORTEM-GROSS-EXAMINATION-BRAIN-SPINAL-CORD

    CPT 88007: Gross Autopsy Examination Including Brain and Spinal Cord

    CPT-88012-INFANT-POSTMORTEM-GROSS-ANALYSIS-BRAIN-INCLUDED

    CPT 88012: Gross Postmortem Examination of Infant, Including Brain

    CPT-88014-STILLBORN-NEWBORN-GROSS-ANALYSIS-INCLUDING-BRAIN

    CPT 88014: Gross Analysis of Stillborn or Newborn Including Brain

    CPT-88016-GROSS-ANALYSIS-MACERATED-STILLBORN

    CPT 88016: Gross Examination of Macerated Stillborn

    CPT-88020-POSTMORTEM-TECHNICAL-GROSS-AND-MICROSCOPIC-EXAM-EXCLUDING-CNS

    CPT 88020: Autopsy, External and Internal Examination Excluding CNS

    CPT-88027-POSTMORTEM-PATHOLOGIC-EXAMINATION-BRAIN-SPINAL-CORD

    CPT 88027: Autopsy Technical Exam Including Brain and Spinal Cord

    CPT-88028-INFANT-POSTMORTEM-TECHNICAL-AUTOPSY

    CPT 88028: Technical Infant Postmortem Examination

    CPT-88029-NEONATAL-STILLBORN-POSTMORTEM-PATHOLOGY-INCLUDING-BRAIN

    CPT 88029: Postmortem Exam of Stillborn/Newborn, Gross and Microscopic

    Showing 1–10 of 15

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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