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    v1.0.30
    OpenPayerBilling CodesAntimicrobial Susceptibility StudiesCPT cpt-87197-bacterial-titer-antibiotic-susceptibility
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    CPT 87197: Bacterial Titer for Antibiotic Susceptibility

    CPT code 87197 describes a laboratory procedure in which a technologist or lab analyst performs a bacterial titer using patient serum to assess susceptibility to a specific antibiotic dosage, a microbiology diagnostic test aimed at guiding antimicrobial therapy; the service type is antimicrobial susceptibility testing / bacteriology serologic titer, and the typical site of service is a clinical laboratory or hospital laboratory where serum-based susceptibility assays are performed.

    For related coverage guidance, see recent payer policy updates: Biomarker Testing for Autoimmune Rheumatic Disease, Immunopharmacologic Monitoring of Therapeutic Serum Antibodies, Immune Cell Function Assay.

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    Clinical & Coding Specifications

    Clinical Context

    A 56-year-old patient presents with a bloodstream infection secondary to a suspected gram-negative organism. The inpatient infectious disease team orders a bacterial serum titer to determine the minimum inhibitory concentration (MIC) and the patient’s susceptibility to a targeted antibiotic dose. A venous blood specimen is collected and routed to the hospital microbiology laboratory. The lab technologist isolates the organism and a lab analyst performs a bacterial titer using the patient’s serum to determine susceptibility at specific antibiotic dosages. Results inform antimicrobial stewardship decisions, dosing adjustments, or a change in therapy. Typical site of service is the hospital clinical microbiology laboratory or an independent clinical laboratory supporting inpatient and outpatient providers. The clinical workflow includes specimen collection, receipt and accessioning, organism identification, preparation of serial dilutions or antibiotic concentrations, incubation, interpretation of titer endpoints, documentation in the laboratory information system, and result reporting to the ordering clinician.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    87070Antimicrobial susceptibility; single procedure, disk/strip methodCommonly performed alongside bacterial titer for organism susceptibility confirmation using standardized antimicrobial susceptibility testing methods
    87205Culture, other source, bacterial; each isolate identifiedPerformed before titering to isolate and identify the bacterial organism from the clinical specimen
    87076Antimicrobial susceptibility; interpretive reportProvides interpretive reporting that complements titer results to guide therapy
    87449Infectious agent detection by nucleic acid (e.g., PCR), multiple organisms or targetsPerformed before or in parallel when molecular identification is needed to direct susceptibility testing
    87880Infectious agent antigen detection by immunoassay, single step methodRapid testing that may precede culture and subsequent bacterial titering in the diagnostic workflow

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RH0000X
    363L00000X
    208000000X
    207Q00000X
    344600000X
    1835C0206X
    2279P1004X
    3336M0002X

    Related Payer Policy Updates

    Specialty: Immunology/Rheumatology1 / 3

    10 rows

    PolicyPayerEffective Date
    Biomarker Testing for Autoimmune Rheumatic DiseaseOscar Health2026-10-01
    Immunopharmacologic Monitoring of Therapeutic Serum AntibodiesOscar Health2026-10-01
    Immune Cell Function AssayOscar Health2026-10-01
    Biomarker Testing for Autoimmune Rheumatic DiseaseBlue Cross Blue Shield - New Mexico2026-09-04
    Inflammatory Conditions - Orencia Intravenous Preferred Specialty Management Policy for Legacy Prescription Drug ListsCigna2026-09-01
    Secukinumab (Cosentyx) — intravenous (Medicare Advantage)blue cross blue shield - louisiana2026-09-01
    Intravenous Immune Globulin (IVIG) — indications and authorization criteriaBlue Cross Blue Shield - Iowa2026-08-28
    Infliximab Intravenous Products Preferred Specialty Management PolicyCigna2026-08-15
    Kineret (anakinra) — Coverage CriteriaBlue Cross Blue Shield - Iowa2026-08-14
    Actimmune (interferon gamma-1b) — Prior Authorization and Coverage Criteriameridian_health_plan_of_michigan2026-08-01

    Related Codes

    CPT-87181-ANTIMICROBIAL-SUSCEPTIBILITY-GRADIENT-DIFFUSION-TEST

    CPT 87181: Antimicrobial Susceptibility Test, Gradient Diffusion

    CPT-87182-MULTIPLEX-CARBAPENEMASE-IMMUNOASSAY

    CPT 87182: Multiplex Carbapenemase Immunoassay

    CPT-87183-CARBAPENEM-RESISTANCE-GENE-DETECTION-PER-ISOLATE

    CPT 87183: Detection of Carbapenem Resistance Genes, Per Isolate

    CPT-87184-ANTIMICROBIAL-SUSCEPTIBILITY-DISK-DIFFUSION

    CPT 87184: Antimicrobial Susceptibility by Disk Diffusion (up to 12 agents)

    CPT-87185-ANTIMICROBIAL-ENZYME-DETECTION-SUSCEPTIBILITY-TEST

    CPT 87185: Antimicrobial Susceptibility Enzyme Detection

    CPT-87186-ANTIMICROBIAL-SUSCEPTIBILITY-TESTING-DILUTION-METHODS

    CPT 87186: Antimicrobial Susceptibility Testing by Dilution Methods

    CPT-87187-MLC-ANTIMICROBIAL-SUSCEPTIBILITY-TESTING

    CPT 87187: Minimum Lethal Concentration (Antimicrobial Susceptibility)

    CPT-87188-ANTIMICROBIAL-SUSCEPTIBILITY-MACROBROTH-DILUTION

    CPT 87188: Macrobroth Dilution Antimicrobial Susceptibility Test

    CPT-87190-MYCOBACTERIA-PROPORTION-METHOD-SUSCEPTIBILITY-TESTING

    CPT 87190: Mycobacteria Susceptibility Testing, Proportion Method

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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