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    v1.0.30
    OpenPayerBilling CodesAntimicrobial Susceptibility StudiesCPT cpt-87183-carbapenem-resistance-gene-detection-per-isolate
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    CPT 87183: Detection of Carbapenem Resistance Genes, Per Isolate

    CPT code 87183 describes a laboratory molecular amplified probe test performed by a lab analyst to detect carbapenem resistance genes (for example, blaKPC, blaNDM, blaVIM, blaOXA-48, blaIMP) in an organism grown in culture from a patient specimen; the service type is molecular infectious disease testing and the typical site of service is a clinical microbiology laboratory with results reported per isolate.

    For related coverage guidance, see recent payer policy updates: Biomarker Testing for Autoimmune Rheumatic Disease, Immunopharmacologic Monitoring of Therapeutic Serum Antibodies, Immune Cell Function Assay.

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    Clinical & Coding Specifications

    Clinical Context

    A hospitalized adult patient with a prior positive bacterial culture from blood or urine grows a Gram-negative organism suspected of carbapenem resistance. The hospital microbiology laboratory subcultures the isolate and performs molecular testing to detect carbapenemase genes. A clinical workflow: the specimen is collected and cultured; if growth suggests Enterobacterales or other Gram-negative bacilli with decreased susceptibility to carbapenems on initial susceptibility testing, the lab technologist selects molecular testing. The lab analyst performs an amplified probe assay to detect genes such as blaKPC, blaNDM, blaVIM, blaOXA-48, or blaIMP. Results are reported per isolate and routed to the treating infectious disease physician and infection prevention team for surveillance and antimicrobial stewardship. Typical sites of service include the hospital microbiology laboratory, reference laboratory, or large outpatient diagnostic laboratory. Typical patient scenarios include bloodstream infection, complicated urinary tract infection, ventilator-associated pneumonia, or colonization screening in an outbreak setting where rapid identification of carbapenemase genes guides infection control and epidemiologic tracking.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    87186Antimicrobial susceptibility testing by automated method for bacteria; per organismPhenotypic susceptibility testing often precedes or complements molecular carbapenemase gene detection
    87070Culture, bacterial; any other source except urine, blood, or stoolPrimary culture from non-urine sources that may yield isolates for subsequent molecular testing
    87081Culture, bacterial, aerobic, with isolation and presumptive identificationInitial culture and isolation procedures that produce the isolate tested by 87183
    87471Infectious agent detection by nucleic acid (DNA or RNA); Chlamydia trachomatis, amplified probe techniqueExample companion molecular technique format (amplified probe) demonstrating similar lab workflows and instrumentation—methodologically related
    87651Infectious agent detection by nucleic acid (DNA or RNA); SARS-CoV-2, amplified probe techniqueAnother amplified probe assay example reflecting lab platforms and reporting workflows commonly used alongside bacterial molecular assays

    Related Modifiers

    5 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RH0000X
    207K00000X
    310400000X
    207L00000X
    2080C0008X
    146D00000X
    2471M1202X
    103TH0100X

    Related Payer Policy Updates

    Specialty: Immunology/Rheumatology1 / 3

    10 rows

    PolicyPayerEffective Date
    Biomarker Testing for Autoimmune Rheumatic DiseaseOscar Health2026-10-01
    Immunopharmacologic Monitoring of Therapeutic Serum AntibodiesOscar Health2026-10-01
    Immune Cell Function AssayOscar Health2026-10-01
    Biomarker Testing for Autoimmune Rheumatic DiseaseBlue Cross Blue Shield - New Mexico2026-09-04
    Inflammatory Conditions - Orencia Intravenous Preferred Specialty Management Policy for Legacy Prescription Drug ListsCigna2026-09-01
    Secukinumab (Cosentyx) — intravenous (Medicare Advantage)blue cross blue shield - louisiana2026-09-01
    Intravenous Immune Globulin (IVIG) — indications and authorization criteriaBlue Cross Blue Shield - Iowa2026-08-28
    Infliximab Intravenous Products Preferred Specialty Management PolicyCigna2026-08-15
    Kineret (anakinra) — Coverage CriteriaBlue Cross Blue Shield - Iowa2026-08-14
    Actimmune (interferon gamma-1b) — Prior Authorization and Coverage Criteriameridian_health_plan_of_michigan2026-08-01

    Related Codes

    CPT-87181-ANTIMICROBIAL-SUSCEPTIBILITY-GRADIENT-DIFFUSION-TEST

    CPT 87181: Antimicrobial Susceptibility Test, Gradient Diffusion

    CPT-87182-MULTIPLEX-CARBAPENEMASE-IMMUNOASSAY

    CPT 87182: Multiplex Carbapenemase Immunoassay

    CPT-87184-ANTIMICROBIAL-SUSCEPTIBILITY-DISK-DIFFUSION

    CPT 87184: Antimicrobial Susceptibility by Disk Diffusion (up to 12 agents)

    CPT-87185-ANTIMICROBIAL-ENZYME-DETECTION-SUSCEPTIBILITY-TEST

    CPT 87185: Antimicrobial Susceptibility Enzyme Detection

    CPT-87186-ANTIMICROBIAL-SUSCEPTIBILITY-TESTING-DILUTION-METHODS

    CPT 87186: Antimicrobial Susceptibility Testing by Dilution Methods

    CPT-87187-MLC-ANTIMICROBIAL-SUSCEPTIBILITY-TESTING

    CPT 87187: Minimum Lethal Concentration (Antimicrobial Susceptibility)

    CPT-87188-ANTIMICROBIAL-SUSCEPTIBILITY-MACROBROTH-DILUTION

    CPT 87188: Macrobroth Dilution Antimicrobial Susceptibility Test

    CPT-87190-MYCOBACTERIA-PROPORTION-METHOD-SUSCEPTIBILITY-TESTING

    CPT 87190: Mycobacteria Susceptibility Testing, Proportion Method

    CPT-87197-BACTERIAL-TITER-ANTIBIOTIC-SUSCEPTIBILITY

    CPT 87197: Bacterial Titer for Antibiotic Susceptibility

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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