CPT 87183: Detection of Carbapenem Resistance Genes, Per Isolate

CPT code 87183 describes a laboratory molecular amplified probe test performed by a lab analyst to detect carbapenem resistance genes (for example, blaKPC, blaNDM, blaVIM, blaOXA-48, blaIMP) in an organism grown in culture from a patient specimen; the service type is molecular infectious disease testing and the typical site of service is a clinical microbiology laboratory with results reported per isolate.

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CPT 87183: Detection of Carbapenem Resistance Genes, Per Isolate

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Get alerted when payer policies referencing 87183 are released or updated.

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Receive email alerts as soon as relevant payer policies are published or updated.

Clinical & Coding Specifications

Clinical Context

A hospitalized adult patient with a prior positive bacterial culture from blood or urine grows a Gram-negative organism suspected of carbapenem resistance. The hospital microbiology laboratory subcultures the isolate and performs molecular testing to detect carbapenemase genes. A clinical workflow: the specimen is collected and cultured; if growth suggests Enterobacterales or other Gram-negative bacilli with decreased susceptibility to carbapenems on initial susceptibility testing, the lab technologist selects molecular testing. The lab analyst performs an amplified probe assay to detect genes such as blaKPC, blaNDM, blaVIM, blaOXA-48, or blaIMP. Results are reported per isolate and routed to the treating infectious disease physician and infection prevention team for surveillance and antimicrobial stewardship. Typical sites of service include the hospital microbiology laboratory, reference laboratory, or large outpatient diagnostic laboratory. Typical patient scenarios include bloodstream infection, complicated urinary tract infection, ventilator-associated pneumonia, or colonization screening in an outbreak setting where rapid identification of carbapenemase genes guides infection control and epidemiologic tracking.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`87186`	Antimicrobial susceptibility testing by automated method for bacteria; per organism	Phenotypic susceptibility testing often precedes or complements molecular carbapenemase gene detection
`87070`	Culture, bacterial; any other source except urine, blood, or stool	Primary culture from non-urine sources that may yield isolates for subsequent molecular testing
`87081`	Culture, bacterial, aerobic, with isolation and presumptive identification	Initial culture and isolation procedures that produce the isolate tested by `87183`
`87471`	Infectious agent detection by nucleic acid (DNA or RNA); Chlamydia trachomatis, amplified probe technique	Example companion molecular technique format (amplified probe) demonstrating similar lab workflows and instrumentation—methodologically related
`87651`	Infectious agent detection by nucleic acid (DNA or RNA); SARS-CoV-2, amplified probe technique	Another amplified probe assay example reflecting lab platforms and reporting workflows commonly used alongside bacterial molecular assays

Related Modifiers

5 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
90	Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…	- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
91	Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…	- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
77	Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…	- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207RH0000X	Hematology (Internal Medicine) Physician	An internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
207K00000X	Allergy & Immunology Physician	An allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
310400000X	Assisted Living Facility	A facility providing supportive services to individuals who can function independently in most areas of activity, but need assistance and/or monitorin…
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
2080C0008X	Child Abuse Pediatrics Physician	A Child Abuse Pediatrician serves as a resource to children, families and communities by accurately diagnosing abuse; consulting with community agenci…
146D00000X	Personal Emergency Response Attendant	Individuals that are specially trained to assist patients living at home with urgent/emergent situations. These individuals must be able to perform C…
2471M1202X	Magnetic Resonance Imaging Radiologic Technologist	A radiologic technologist who specializes in magnetic resonance imaging (MRI) and is appropriately educated and trained, consistent with nationally re…
103TH0100X	Health Service Psychologist	A psychologist, certified/licensed at the independent practice level in his/her state, who is duly trained and experienced in the delivery of direct, …

CPT 87181: Antimicrobial Susceptibility Test, Gradient Diffusion

CPT-87182-MULTIPLEX-CARBAPENEMASE-IMMUNOASSAY

CPT 87182: Multiplex Carbapenemase Immunoassay

CPT-87184-ANTIMICROBIAL-SUSCEPTIBILITY-DISK-DIFFUSION

CPT 87184: Antimicrobial Susceptibility by Disk Diffusion (up to 12 agents)

CPT-87185-ANTIMICROBIAL-ENZYME-DETECTION-SUSCEPTIBILITY-TEST

CPT 87185: Antimicrobial Susceptibility Enzyme Detection

CPT-87186-ANTIMICROBIAL-SUSCEPTIBILITY-TESTING-DILUTION-METHODS

CPT 87186: Antimicrobial Susceptibility Testing by Dilution Methods

CPT-87187-MLC-ANTIMICROBIAL-SUSCEPTIBILITY-TESTING

CPT 87187: Minimum Lethal Concentration (Antimicrobial Susceptibility)

CPT-87188-ANTIMICROBIAL-SUSCEPTIBILITY-MACROBROTH-DILUTION

CPT 87188: Macrobroth Dilution Antimicrobial Susceptibility Test

CPT-87190-MYCOBACTERIA-PROPORTION-METHOD-SUSCEPTIBILITY-TESTING

CPT 87190: Mycobacteria Susceptibility Testing, Proportion Method

CPT-87197-BACTERIAL-TITER-ANTIBIOTIC-SUSCEPTIBILITY

CPT 87197: Bacterial Titer for Antibiotic Susceptibility

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`87186`	Antimicrobial susceptibility testing by automated method for bacteria; per organism	Phenotypic susceptibility testing often precedes or complements molecular carbapenemase gene detection
`87070`	Culture, bacterial; any other source except urine, blood, or stool	Primary culture from non-urine sources that may yield isolates for subsequent molecular testing
`87081`	Culture, bacterial, aerobic, with isolation and presumptive identification	Initial culture and isolation procedures that produce the isolate tested by `87183`
`87471`	Infectious agent detection by nucleic acid (DNA or RNA); Chlamydia trachomatis, amplified probe technique	Example companion molecular technique format (amplified probe) demonstrating similar lab workflows and instrumentation—methodologically related
`87651`	Infectious agent detection by nucleic acid (DNA or RNA); SARS-CoV-2, amplified probe technique	Another amplified probe assay example reflecting lab platforms and reporting workflows commonly used alongside bacterial molecular assays

Related Modifiers

5 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
90	Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…	- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
91	Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…	- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
77	Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…	- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207RH0000X	Hematology (Internal Medicine) Physician	An internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
207K00000X	Allergy & Immunology Physician	An allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
310400000X	Assisted Living Facility	A facility providing supportive services to individuals who can function independently in most areas of activity, but need assistance and/or monitorin…
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
2080C0008X	Child Abuse Pediatrics Physician	A Child Abuse Pediatrician serves as a resource to children, families and communities by accurately diagnosing abuse; consulting with community agenci…
146D00000X	Personal Emergency Response Attendant	Individuals that are specially trained to assist patients living at home with urgent/emergent situations. These individuals must be able to perform C…
2471M1202X	Magnetic Resonance Imaging Radiologic Technologist	A radiologic technologist who specializes in magnetic resonance imaging (MRI) and is appropriately educated and trained, consistent with nationally re…
103TH0100X	Health Service Psychologist	A psychologist, certified/licensed at the independent practice level in his/her state, who is duly trained and experienced in the delivery of direct, …

CPT 87181: Antimicrobial Susceptibility Test, Gradient Diffusion

CPT-87182-MULTIPLEX-CARBAPENEMASE-IMMUNOASSAY

CPT 87182: Multiplex Carbapenemase Immunoassay

CPT-87184-ANTIMICROBIAL-SUSCEPTIBILITY-DISK-DIFFUSION

CPT 87184: Antimicrobial Susceptibility by Disk Diffusion (up to 12 agents)

CPT-87185-ANTIMICROBIAL-ENZYME-DETECTION-SUSCEPTIBILITY-TEST

CPT 87185: Antimicrobial Susceptibility Enzyme Detection

CPT-87186-ANTIMICROBIAL-SUSCEPTIBILITY-TESTING-DILUTION-METHODS

CPT 87186: Antimicrobial Susceptibility Testing by Dilution Methods

CPT-87187-MLC-ANTIMICROBIAL-SUSCEPTIBILITY-TESTING

CPT 87187: Minimum Lethal Concentration (Antimicrobial Susceptibility)

CPT-87188-ANTIMICROBIAL-SUSCEPTIBILITY-MACROBROTH-DILUTION

CPT 87188: Macrobroth Dilution Antimicrobial Susceptibility Test

CPT-87190-MYCOBACTERIA-PROPORTION-METHOD-SUSCEPTIBILITY-TESTING

CPT 87190: Mycobacteria Susceptibility Testing, Proportion Method

CPT-87197-BACTERIAL-TITER-ANTIBIOTIC-SUSCEPTIBILITY

CPT 87197: Bacterial Titer for Antibiotic Susceptibility

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

CPT 87183: Detection of Carbapenem Resistance Genes, Per Isolate

Sign up for cpt 87183 policy alerts

OpenPayer

CPT 87183: Detection of Carbapenem Resistance Genes, Per Isolate

Sign up for cpt 87183 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

References

CPT 87183: Detection of Carbapenem Resistance Genes, Per Isolate

Sign up for cpt 87183 policy alerts

CPT 87183: Detection of Carbapenem Resistance Genes, Per Isolate

Sign up for cpt 87183 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

What does CPT code 87183 represent and where is it typically performed?

Which modifiers are commonly associated with CPT 87183 and when are they applied?

In what clinical scenarios is the carbapenemase gene detection test (87183) typically used?

Which other CPT codes are commonly associated with or performed alongside 87183?

Which payers are included and does the page provide reimbursement rates or specific payer policies?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

What does CPT code 87183 represent and where is it typically performed?

Which modifiers are commonly associated with CPT 87183 and when are they applied?

In what clinical scenarios is the carbapenemase gene detection test (87183) typically used?

Which other CPT codes are commonly associated with or performed alongside 87183?

Which payers are included and does the page provide reimbursement rates or specific payer policies?

References