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    v1.0.30
    OpenPayerBilling CodesAntimicrobial Susceptibility StudiesCPT cpt-87182-multiplex-carbapenemase-immunoassay
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    CPT 87182: Multiplex Carbapenemase Immunoassay

    CPT code 87182 describes a laboratory multiplex immunoassay performed by a lab analyst to detect whether an organism grown in culture from a patient specimen produces carbapenemase enzymes, reporting qualitative positive/negative results; service type: pathology/laboratory infectious disease testing; typical site of service: clinical microbiology laboratory or hospital lab.

    For related coverage guidance, see recent payer policy updates: Biomarker Testing for Autoimmune Rheumatic Disease, Immunopharmacologic Monitoring of Therapeutic Serum Antibodies, Immune Cell Function Assay.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 68-year-old hospitalized patient on a ventilator develops a ventilator-associated pneumonia with Gram-negative bacilli isolated from a tracheal aspirate culture. The clinical laboratory grows an organism in culture and the treating team requests rapid identification of carbapenemase production to guide infection control and antimicrobial selection. A microbiology technologist performs a multiplex immunoassay that qualitatively screens the cultured isolate for multiple carbapenemase enzymes (e.g., KPC, NDM, VIM, IMP, OXA-48). Results are reported as positive or negative and communicated to the clinical team and infection prevention program. Typical workflow steps include specimen receipt and accessioning, culture and isolate growth, performance of the multiplex immunoassay by a trained laboratory analyst, documentation of results in the laboratory information system, and notification to the ordering clinician and infection control. Typical site of service is an acute care hospital clinical microbiology laboratory or reference laboratory supporting inpatient and outpatient specimen testing. Typical service type is a laboratory diagnostic test (microbiology immunoassay) performed by trained laboratory personnel using cultured isolates.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    87181Antigen detection; immunoassay for bacterial pathogens, single analyteMay be performed when single-target antigen testing is used instead of multiplex screening for carbapenemase detection.
    87184Phenotypic method for carbapenemase detection (e.g., modified carbapenem inactivation method)Alternative or complementary testing approach to immunoassay; can be used for phenotypic confirmation of enzyme activity.
    87480Infectious agent detection by nucleic acid (e.g., PCR) for multiple analytesMolecular assays for carbapenemase genes (e.g., blaKPC, blaNDM) often performed alongside or following immunoassay for genotypic confirmation.
    87070Culture, bacterial; any source, quantitative colony count not applicableInitial culture and isolation of the organism from clinical specimens precedes carbapenemase immunoassay testing.
    87077Antimicrobial susceptibility testing; dilution and interpretive report (e.g., MIC)Antimicrobial susceptibility testing is typically performed to determine carbapenem resistance profile and guide therapy, complementing carbapenemase screening.

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RC0000X
    207K00000X
    207L00000X
    103T00000X
    102X00000X
    207VC0200X
    335U00000X
    163WC2100X

    Related ICD-10-CM Codes

    28 rows

    ICD-10-CM CodeDescription
    A41.51Sepsis due to Escherichia coli [E. coli]
    A41.9Sepsis, unspecified organism
    A49.01Methicillin susceptible Staphylococcus aureus infection, unspecified site
    A49.9Bacterial infection, unspecified
    A52.09Other cardiovascular syphilis
    B96.5Pseudomonas (aeruginosa) (mallei) (pseudomallei) as the cause of diseases classified elsewhere
    E11.9Type 2 diabetes mellitus without complications
    G00.9Bacterial meningitis, unspecified
    I10Essential (primary) hypertension
    J15.9Unspecified bacterial pneumonia

    Showing 1–10 of 28

    Related Payer Policy Updates

    Specialty: Immunology/Rheumatology1 / 3

    10 rows

    PolicyPayerEffective Date
    Biomarker Testing for Autoimmune Rheumatic DiseaseOscar Health2026-10-01
    Immunopharmacologic Monitoring of Therapeutic Serum AntibodiesOscar Health2026-10-01
    Immune Cell Function AssayOscar Health2026-10-01
    Biomarker Testing for Autoimmune Rheumatic DiseaseBlue Cross Blue Shield - New Mexico2026-09-04
    Inflammatory Conditions - Orencia Intravenous Preferred Specialty Management Policy for Legacy Prescription Drug ListsCigna2026-09-01
    Secukinumab (Cosentyx) — intravenous (Medicare Advantage)blue cross blue shield - louisiana2026-09-01
    Intravenous Immune Globulin (IVIG) — indications and authorization criteriaBlue Cross Blue Shield - Iowa2026-08-28
    Infliximab Intravenous Products Preferred Specialty Management PolicyCigna2026-08-15
    Kineret (anakinra) — Coverage CriteriaBlue Cross Blue Shield - Iowa2026-08-14
    Actimmune (interferon gamma-1b) — Prior Authorization and Coverage Criteriameridian_health_plan_of_michigan2026-08-01

    Related Codes

    CPT-87181-ANTIMICROBIAL-SUSCEPTIBILITY-GRADIENT-DIFFUSION-TEST

    CPT 87181: Antimicrobial Susceptibility Test, Gradient Diffusion

    CPT-87183-CARBAPENEM-RESISTANCE-GENE-DETECTION-PER-ISOLATE

    CPT 87183: Detection of Carbapenem Resistance Genes, Per Isolate

    CPT-87184-ANTIMICROBIAL-SUSCEPTIBILITY-DISK-DIFFUSION

    CPT 87184: Antimicrobial Susceptibility by Disk Diffusion (up to 12 agents)

    CPT-87185-ANTIMICROBIAL-ENZYME-DETECTION-SUSCEPTIBILITY-TEST

    CPT 87185: Antimicrobial Susceptibility Enzyme Detection

    CPT-87186-ANTIMICROBIAL-SUSCEPTIBILITY-TESTING-DILUTION-METHODS

    CPT 87186: Antimicrobial Susceptibility Testing by Dilution Methods

    CPT-87187-MLC-ANTIMICROBIAL-SUSCEPTIBILITY-TESTING

    CPT 87187: Minimum Lethal Concentration (Antimicrobial Susceptibility)

    CPT-87188-ANTIMICROBIAL-SUSCEPTIBILITY-MACROBROTH-DILUTION

    CPT 87188: Macrobroth Dilution Antimicrobial Susceptibility Test

    CPT-87190-MYCOBACTERIA-PROPORTION-METHOD-SUSCEPTIBILITY-TESTING

    CPT 87190: Mycobacteria Susceptibility Testing, Proportion Method

    CPT-87197-BACTERIAL-TITER-ANTIBIOTIC-SUSCEPTIBILITY

    CPT 87197: Bacterial Titer for Antibiotic Susceptibility

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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