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    v1.0.30
    OpenPayerBilling CodesAntimicrobial Susceptibility StudiesCPT cpt-87190-mycobacteria-proportion-method-susceptibility-testing
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    CPT 87190: Mycobacteria Susceptibility Testing, Proportion Method

    CPT code 87190 describes laboratory technical procedures for performing a proportion-method antimicrobial susceptibility test on a mycobacteria culture isolate; service type: microbiology susceptibility testing, typical site of service: clinical microbiology laboratory or hospital laboratory performing culture-based mycobacterial testing.

    For related coverage guidance, see recent payer policy updates: Biomarker Testing for Autoimmune Rheumatic Disease, Immunopharmacologic Monitoring of Therapeutic Serum Antibodies, Immune Cell Function Assay.

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    Clinical & Coding Specifications

    Clinical Context

    A laboratory receives a respiratory specimen from a patient with suspected pulmonary mycobacterial infection after initial culture growth identifies a mycobacterial isolate. The specimen is cultured at a microbiology reference laboratory. A clinical laboratory scientist or medical technologist performs susceptibility testing using the proportion method to determine the isolate's sensitivity to first- and second-line antimycobacterial agents. Results guide infectious disease clinicians and pulmonologists in selecting effective therapy for infections such as pulmonary tuberculosis or non-tuberculous mycobacterial (NTM) disease. Typical workflow: specimen accessioning → isolate confirmation and identification (smear, culture, molecular ID) → set up proportion method susceptibility panels → incubate and read proportion plates/tubes → report minimum inhibitory concentrations or proportion-based susceptibility interpretations to the ordering clinician. Typical site of service: hospital clinical microbiology laboratory or regional reference laboratory performing mycobacterial susceptibility testing.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    87015Culture, bacterial; blood, aerobic and anaerobicPerformed earlier in workflow when bloodstream culture is required to detect bacterial growth prior to susceptibility testing.
    87077Culture, respiratory, bacterial, screening; multiple pathogens, includes isolation and presumptive identificationMay precede mycobacterial-specific culture by initial respiratory culture workup.
    87116Culture, mycobacteria, other than M. tuberculosis complex; isolation or recoveryPerformed when initially isolating mycobacterial organisms before susceptibility testing with 87190.
    87481Infectious agent detection by nucleic acid (e.g., amplification), Mycobacterium tuberculosis complex, amplified probe techniqueMolecular identification tests commonly performed before or alongside culture and susceptibility to quickly identify M. tuberculosis complex.
    87207Smear, primary source with interpretation; fluorescent or auramine-rhodamine stain for acid-fast bacilliRapid microscopic screening used earlier in the diagnostic pathway prior to culture and susceptibility.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    363L00000X
    207R00000X
    207P00000X
    207Q00000X
    208800000X
    311500000X
    101YP2500X
    261QR0405X

    Related Payer Policy Updates

    Specialty: Immunology/Rheumatology1 / 3

    10 rows

    PolicyPayerEffective Date
    Biomarker Testing for Autoimmune Rheumatic DiseaseOscar Health2026-10-01
    Immunopharmacologic Monitoring of Therapeutic Serum AntibodiesOscar Health2026-10-01
    Immune Cell Function AssayOscar Health2026-10-01
    Biomarker Testing for Autoimmune Rheumatic DiseaseBlue Cross Blue Shield - New Mexico2026-09-04
    Inflammatory Conditions - Orencia Intravenous Preferred Specialty Management Policy for Legacy Prescription Drug ListsCigna2026-09-01
    Secukinumab (Cosentyx) — intravenous (Medicare Advantage)blue cross blue shield - louisiana2026-09-01
    Intravenous Immune Globulin (IVIG) — indications and authorization criteriaBlue Cross Blue Shield - Iowa2026-08-28
    Infliximab Intravenous Products Preferred Specialty Management PolicyCigna2026-08-15
    Kineret (anakinra) — Coverage CriteriaBlue Cross Blue Shield - Iowa2026-08-14
    Actimmune (interferon gamma-1b) — Prior Authorization and Coverage Criteriameridian_health_plan_of_michigan2026-08-01

    Related Codes

    CPT-87181-ANTIMICROBIAL-SUSCEPTIBILITY-GRADIENT-DIFFUSION-TEST

    CPT 87181: Antimicrobial Susceptibility Test, Gradient Diffusion

    CPT-87182-MULTIPLEX-CARBAPENEMASE-IMMUNOASSAY

    CPT 87182: Multiplex Carbapenemase Immunoassay

    CPT-87183-CARBAPENEM-RESISTANCE-GENE-DETECTION-PER-ISOLATE

    CPT 87183: Detection of Carbapenem Resistance Genes, Per Isolate

    CPT-87184-ANTIMICROBIAL-SUSCEPTIBILITY-DISK-DIFFUSION

    CPT 87184: Antimicrobial Susceptibility by Disk Diffusion (up to 12 agents)

    CPT-87185-ANTIMICROBIAL-ENZYME-DETECTION-SUSCEPTIBILITY-TEST

    CPT 87185: Antimicrobial Susceptibility Enzyme Detection

    CPT-87186-ANTIMICROBIAL-SUSCEPTIBILITY-TESTING-DILUTION-METHODS

    CPT 87186: Antimicrobial Susceptibility Testing by Dilution Methods

    CPT-87187-MLC-ANTIMICROBIAL-SUSCEPTIBILITY-TESTING

    CPT 87187: Minimum Lethal Concentration (Antimicrobial Susceptibility)

    CPT-87188-ANTIMICROBIAL-SUSCEPTIBILITY-MACROBROTH-DILUTION

    CPT 87188: Macrobroth Dilution Antimicrobial Susceptibility Test

    CPT-87197-BACTERIAL-TITER-ANTIBIOTIC-SUSCEPTIBILITY

    CPT 87197: Bacterial Titer for Antibiotic Susceptibility

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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