CPT code 86812 represents a serologic laboratory test to identify a single human leukocyte antigen (HLA) Class I antigen—one of the A, B, or C antigens. This code captures single-antigen serologic HLA typing, a procedure used in immunogenetics for transplant compatibility assessment, disease association studies, and certain immunologic evaluations. Nationally, HLA testing matters for organ and tissue transplantation programs, immunology research, and specialized diagnostic workflows.

Key payers included in this analysis are Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. The publication provides an overview useful to clinical laboratory managers, billing and coding teams, and policy analysts.

Readers will learn the clinical context and typical service setting for CPT code 86812, common billing considerations, and where this service fits within laboratory and transplant care pathways. The report outlines payer coverage landscape at a national level, summarizes available benchmarks and utilization patterns when present, and highlights policy and coding updates that affect HLA serologic testing reimbursement and documentation. Data not available in the input will be explicitly noted in relevant sections.