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    v1.0.30
    OpenPayerBilling CodesTissue Typing Immunological ProceduresCPT cpt-86808-hla-percent-reactive-antibody-screening
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    CPT 86808: HLA Percent Reactive Antibody Screen

    CPT code 86808 describes a laboratory screening test that measures the percent reactive antibody in a transplant recipient's serum against potential donor human leukocyte antigens (HLA) to evaluate the likelihood of transplant incompatibility; service type: immunohematology serologic screening, typical site of service: clinical laboratory or hospital laboratory.

    For related coverage guidance, see recent payer policy updates: Biomarker Testing for Autoimmune Rheumatic Disease, Immunopharmacologic Monitoring of Therapeutic Serum Antibodies, Immune Cell Function Assay.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 47-year-old woman with end-stage renal disease is evaluated for a potential kidney transplant from a living-related donor. Pre-transplant workup includes crossmatch and antibody assessment to evaluate immunologic compatibility. The clinical laboratory receives the recipient's serum and performs HLA antibody screening to determine the percent reactive antibody and identify donor-specific antibodies that would predict transplant incompatibility. Results guide transplant immunology teams in donor selection, virtual crossmatch decisions, and immunosuppression planning. Typical workflow: serum sample collection in an outpatient or hospital phlebotomy setting, transport to an immunology laboratory, testing by a histocompatibility technologist using solid-phase or cell-based assays, result interpretation by a laboratory director, and electronic reporting to the transplant program. Typical sites of service are hospital-based immunology laboratories, independent reference labs, or transplant center laboratories.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    86850Tissue typing; HLA class I (A, B, C) and class II (DR, DQ) by serologic or molecular methodsProvides antigen-level HLA typing for donor and recipient essential for compatibility assessment alongside antibody screening
    86812Crossmatch; lymphocyte (T- and B-lymphocyte)Direct crossmatch testing between recipient serum and donor lymphocytes to confirm compatibility when antibodies are detected
    86355Antibody identification; RBC (for serology)Analogous immunohematology antibody identification procedures; conceptually similar methodology for antibody characterization in transplant setting
    88360Immunocytochemistry; per specimen (used for specialized immunologic stains)Occasionally used in pathology workflows supporting transplant immunology for tissue-based immunologic assessment
    86336Antibody identification by solid-phase methods (single antigen bead assays)Solid-phase single antigen testing to characterize HLA-specific antibodies and determine percent reactive antibody in greater detail

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RH0000X
    208000000X
    207K00000X
    207L00000X
    170300000X
    246ZE0500X
    209800000X
    261QM1101X

    Related ICD-10-CM Codes

    28 rows

    ICD-10-CM CodeDescription
    B18.2Chronic viral hepatitis C
    B19.20Unspecified viral hepatitis C without hepatic coma
    D56.9Thalassemia, unspecified
    D63.1Anemia in chronic kidney disease
    D64.9Anemia, unspecified
    I12.9Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease
    I50.9Heart failure, unspecified
    N18.4Chronic kidney disease, stage 4 (severe)
    N18.5Chronic kidney disease, stage 5
    N18.6End stage renal disease

    Showing 1–10 of 28

    Related Payer Policy Updates

    Specialty: Immunology/Rheumatology1 / 3

    10 rows

    PolicyPayerEffective Date
    Biomarker Testing for Autoimmune Rheumatic DiseaseOscar Health2026-10-01
    Immunopharmacologic Monitoring of Therapeutic Serum AntibodiesOscar Health2026-10-01
    Immune Cell Function AssayOscar Health2026-10-01
    Biomarker Testing for Autoimmune Rheumatic DiseaseBlue Cross Blue Shield - New Mexico2026-09-04
    Inflammatory Conditions - Orencia Intravenous Preferred Specialty Management Policy for Legacy Prescription Drug ListsCigna2026-09-01
    Secukinumab (Cosentyx) — intravenous (Medicare Advantage)blue cross blue shield - louisiana2026-09-01
    Intravenous Immune Globulin (IVIG) — indications and authorization criteriaBlue Cross Blue Shield - Iowa2026-08-28
    Infliximab Intravenous Products Preferred Specialty Management PolicyCigna2026-08-15
    Kineret (anakinra) — Coverage CriteriaBlue Cross Blue Shield - Iowa2026-08-14
    Actimmune (interferon gamma-1b) — Prior Authorization and Coverage Criteriameridian_health_plan_of_michigan2026-08-01

    Related Codes

    CPT-86805-TRANSPLANT-LYMPHOCYTE-CROSSMATCH-COMPATIBILITY-TEST

    CPT 86805: Lymphocyte Crossmatch with Recipient Serum

    CPT-86806-SEROLOGIC-CROSSMATCH-DONOR-LYMPHOCYTE-RECIPIENT-SERUM

    CPT 86806: Lymphocyte Crossmatch, Donor Lymphocytes with Recipient Serum

    CPT-86807-HLA-ANTIBODY-SCREENING-TRANSPLANT-COMPATIBILITY

    CPT 86807: HLA Antibody Percent Reactive Screening

    CPT-86812-HLA-CLASS-I-SINGLE-ANTIGEN-SEROLOGIC-TEST

    CPT 86812: HLA Class I Antigen Serologic Typing

    CPT-86813-HLA-CLASS-I-SEROLOGIC-TYPING

    CPT 86813: HLA Class I Serologic Typing (A, B, C)

    CPT-86816-HLA-CLASS-II-SEROLOGIC-SINGLE-ANTIGEN-TYPING-DR-DQ

    CPT 86816: HLA Class II Single Antigen Serology

    CPT-86817-HLA-CLASS-II-DR-DQ-SEROLOGIC-IDENTIFICATION

    CPT 86817: HLA Class II DR/DQ Serologic Typing

    CPT-86821-HLA-LYMPHOCYTE-CROSSMATCH-COMPATIBILITY-TEST

    CPT 86821: Lymphocyte Crossmatch for HLA Incompatibility

    CPT-86825-HLA-CROSSMATCH-FLOW-CYTOMETRY

    CPT 86825: HLA Crossmatch by Non-Cytotoxic Method

    CPT-86826-HLA-CROSSMATCH-FLOW-CYTOMETRY-BASED-COMPATIBILITY-TEST

    CPT 86826: HLA Crossmatch by Non-Cytotoxic Method

    Showing 1–10 of 19

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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