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    v1.0.28
    OpenPayerBilling CodesChemistry ProceduresCPT cpt-82805-blood-gas-analysis-with-measured-o2-saturation
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    CPT 82805: Blood Gas Analysis with Direct O2 Saturation

    CPT code 82805 describes a laboratory blood gas analysis in which a lab analyst measures any number of blood gas parameters using a blood gas analyzer and the test includes direct measurement of oxygen saturation (O2 saturation); service type is clinical laboratory testing and the typical site of service is a clinical laboratory or hospital laboratory/acute care setting.

    For related coverage guidance, see recent payer policy updates: Salivary Hormone Testing, Parathyroid Hormone, Phosphorus, Calcium, and Magnesium Testing, Bone Turnover Markers Testing.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 68-year-old patient with chronic obstructive pulmonary disease (COPD) presents to the emergency department with progressive shortness of breath, hypoxemia, and altered mental status. The clinician orders an arterial blood gas (ABG) to evaluate ventilation, oxygenation, and acid-base status. A respiratory therapist or phlebotomist obtains an arterial sample (radial artery) and sends it to the hospital laboratory. The laboratory analyst runs the specimen on a blood gas analyzer that measures pH, partial pressures of carbon dioxide (PaCO2) and oxygen (PaO2), bicarbonate (HCO3-), electrolytes if applicable, and includes direct measurement of oxygen saturation (SaO2) per the description of 82805. Results are used by clinicians to guide decisions about supplemental oxygen, noninvasive ventilation, intubation, ventilator settings, and acid-base management. Typical site of service is the hospital laboratory supporting the emergency department, intensive care unit, or inpatient wards. The service type is clinical laboratory testing (blood gas analysis) with direct O2 saturation measurement documented in the laboratory report.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    82803Blood gas; single parameter (e.g., PaCO2 or PaO2)Performed when only one blood gas parameter is measured; 82805 includes multiple parameters plus direct O2 saturation measurement
    82810Blood gas analysis, venous or arterial, multiple parameters, without direct O2 saturation measurementOften ordered alongside or as alternative when direct SaO2 measurement is not required; 82805 specifies direct O2 saturation measurement
    36415Collection of venous blood by venipunctureCommonly performed for concurrent laboratory tests; specimen collection for blood gas typically requires arterial puncture but venous samples may be drawn for comparative labs
    36600Arterial puncture, therapeutic, diagnostic, or monitoring (for blood gas)Procedure code for arterial blood draw used to obtain specimen for 82805 in some billing contexts
    93000Electrocardiogram, routine ECG with at least 12 leads; with interpretation and reportOften performed in parallel when evaluating cardiopulmonary causes of hypoxia; complements blood gas data

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207R00000XInternal Medicine PhysicianA physician who provides long-term, comprehensive care in the office and the hospital, managing both common and complex illness of adolescents, adults…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    363A00000XPhysician AssistantA physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
    207P00000XEmergency Medicine PhysicianAn emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
    133VN1301XOncology Nutrition Registered DietitianAn individual who is a Board Certified Specialist in Oncology Nutrition and provides direct nutrition care for individuals at risk for or diagnosed wi…
    324500000XSubstance Abuse Rehabilitation FacilityA facility or distinct part of a facility that provides a 24 hr therapeutically planned living and rehabilitative intervention environment for the tre…
    173F00000XSleep Specialist (PhD)Sleep medicine is a clinical specialty with a focus on clinical problems that require accurate diagnosis and treatment. The knowledge base of sleep me…
    283X00000XRehabilitation HospitalA hospital or facility that provides health-related, social and/or vocational services to disabled persons to help them attain their maximum functiona…

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    A41.9Sepsis, unspecified organism
    B34.9Viral infection, unspecified
    E87.6Hypokalemia
    G93.1Anoxic brain damage, not elsewhere classified
    I21.9Acute myocardial infarction, unspecified
    I26.99Other pulmonary embolism without acute cor pulmonale
    I50.9Heart failure, unspecified
    J18.9Pneumonia, unspecified organism
    J44.9Chronic obstructive pulmonary disease, unspecified
    J45.909Unspecified asthma, uncomplicated

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Endocrinology1 / 3

    10 rows

    PolicyPayerEffective Date
    Salivary Hormone TestingOscar Health2026-10-01
    Parathyroid Hormone, Phosphorus, Calcium, and Magnesium TestingOscar Health2026-10-01
    Bone Turnover Markers TestingOscar Health2026-10-01
    Testosterone — Coverage Criteria for Measurement and MonitoringOscar Health2026-10-01
    Diabetes Mellitus Testing — Coverage CriteriaOscar Health2026-10-01
    Thyroid Disease TestingOscar Health2026-10-01
    Thyroid Disease Testingblue cross blue shield - louisiana2026-09-15
    Thyroid Disease TestingBlue Cross Blue Shield - New Mexico2026-09-04
    Parathyroid Hormone, Phosphorous, Calcium and Magnesium TestingBlue Cross Blue Shield - New Mexico2026-09-04
    Testosterone laboratory testing and managementPremera Bluecross2026-09-04

    Related Codes

    CPT-82009-KETONE-BODIES-QUALITATIVE-TEST

    CPT 82009: Qualitative Ketone Bodies Test

    CPT-82010-QUANTITATIVE-KETONE-BODIES-ASSAY-SERUM-PLASMA

    CPT 82010: Quantitative Ketone Bodies in Serum or Plasma

    CPT-82013-ACETYLCHOLINESTERASE-QUANTITATIVE-ASSAY

    CPT 82013: Quantitative Acetylcholinesterase (Acetylhydrolase) Assay

    CPT-82016-QUALITATIVE-ACYLCARNITINES-METABOLIC-SCREEN

    CPT 82016: Qualitative Acylcarnitines, Plasma/Serum/Urine

    CPT-82017-QUANTITATIVE-ACYLCARNITINE-ANALYSIS

    CPT 82017: Quantitative Acylcarnitine Analysis

    CPT-82024-QUANTITATIVE-CORTICOTROPIN-ACTH-ASSAY

    CPT 82024: Adrenocorticotropic Hormone (ACTH) Quantitative Assay

    CPT-82030-QUANTITATIVE-CAMP-PLASMA-URINE-ASSAY

    CPT 82030: Quantitative cyclic AMP assay on plasma or urine

    CPT-82040-QUANTITATIVE-ALBUMIN-MEASUREMENT

    CPT 82040: Quantitative Albumin Measurement

    CPT-82042-QUANTITATIVE-ALBUMIN-NONBLOOD-FLUID

    CPT 82042: Albumin Quantitation in Non-Blood Body Fluid

    CPT-82043-URINE-ALBUMIN-QUANTITATION-KIDNEY-DISEASE

    CPT 82043: Urine Albumin Quantitative Assay

    Showing 1–10 of 411

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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