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    v1.0.28
    OpenPayerBilling CodesChemistry ProceduresCPT cpt-84392-urine-sulfate-quantitative-24-hour
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    CPT 84392: Urine Sulfate Quantification, 24-Hour

    CPT code 84392 describes a laboratory procedure for quantitative measurement of sulfate in urine, typically performed on a 24-hour urine specimen to assess sulfate excretion; this is a clinical chemistry test usually processed in a hospital or outpatient clinical laboratory and reported as a discrete laboratory result for diagnostic evaluation and monitoring.

    For related coverage guidance, see recent payer policy updates: Salivary Hormone Testing, Parathyroid Hormone, Phosphorus, Calcium, and Magnesium Testing, Bone Turnover Markers Testing.

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    Table of contents

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    • Billing CodesCPT, HCPCS, DRG & more
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    • ModifiersCPT modifiers & usage
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    Clinical & Coding Specifications

    Clinical Context

    A typical scenario involves an adult patient referred by a primary care provider or nephrologist for quantitative measurement of urinary sulfate to evaluate sulfur amino acid metabolism, suspected metabolic disorders, renal tubular dysfunction, or to monitor occupational or environmental exposure to sulfate-containing compounds. The specimen is usually collected as a 24-hour urine sample with clear patient instructions regarding collection, storage, and avoidance of contaminating substances. The clinical workflow includes order entry by the provider, patient education and collection kit distribution at the clinic or laboratory, return of the 24-hour urinespecimen to the outpatient laboratory or hospital laboratory, accessioning by the lab, aliquoting and preparation by a medical technologist, performance of theurine sulfate` assay by a laboratory analyst, result validation by a qualified laboratorian or pathologist if necessary, and electronic reporting to the ordering provider. Typical sites of service are outpatient laboratory collection centers, hospital laboratories, or specialty metabolic clinics. Common clinical indications include investigation of abnormal amino acid or sulfur metabolite profiles, unexplained metabolic acidosis or renal tubular disorders, monitoring of occupational exposure, and follow-up of known metabolic conditions affecting sulfate excretion.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    81000Urinalysis, by dip stick or tablet reagent for bilirubin, glucose, hemoglobin, ketones, leukocytes, nitrite, pH, specific gravity, etc.; non-automated, without microscopyOften performed as an initial screening test prior to or alongside quantitative urine sulfate to assess urine characteristics and detect contaminating factors
    82043Assay of urine, creatinine; quantitativeFrequently ordered with urine sulfate in a 24-hour urine panel to normalize sulfate excretion to creatinine or to assess completeness of collection
    82570Assay of creatinine; bloodSerum creatinine may be obtained in parallel to evaluate renal function when interpreting 24-hour urine` sulfate results
    82542Assay of urine, creatine; quantitativeSometimes included in metabolic workups with sulfate measurement in specialty metabolic panels
    83970Assay of urine, amino acids; qualitative or quantitative, eachOrdered in metabolic evaluations where sulfate metabolism or sulfur amino acid disorders are suspected and comprehensive urine amino acid testing is indicated

    Related Modifiers

    5 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    208000000XPediatrics PhysicianA pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
    207K00000XAllergy & Immunology PhysicianAn allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
    2084N0400XNeurology PhysicianA Neurologist specializes in the diagnosis and treatment of diseases or impaired function of the brain, spinal cord, peripheral nerves, muscles, auton…
    207ZP0105XClinical Pathology/Laboratory Medicine PhysicianA pathologist deals with the causes and nature of disease and contributes to diagnosis, prognosis and treatment through knowledge gained by the labora…
    282E00000XLong Term Care HospitalLong-term care hospitals (LTCHs) furnish extended medical and rehabilitative care to individuals who are clinically complex and have multiple acute or…
    347E00000XTransportation BrokerAn organization that provides transportation for individuals who need access to medical care or services and have no other means of transportation. Tr…
    2084N0008XNeuromuscular Medicine (Psychiatry & Neurology) PhysicianA neurologist or child neurologist who specializes in the diagnosis and management of disorders of nerve, muscle or neuromuscular junction, including …

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    E03.9Hypothyroidism, unspecified
    E04.1Nontoxic single thyroid nodule
    E11.9Type 2 diabetes mellitus without complications
    E66.9Obesity, unspecified
    E78.5Hyperlipidemia, unspecified
    E83.2Disorders of zinc metabolism
    E83.51Hypocalcemia
    E83.59Other disorders of calcium metabolism
    E86.0Dehydration
    E88.09Other disorders of plasma-protein metabolism, not elsewhere classified

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Endocrinology1 / 3

    10 rows

    PolicyPayerEffective Date
    Salivary Hormone TestingOscar Health2026-10-01
    Parathyroid Hormone, Phosphorus, Calcium, and Magnesium TestingOscar Health2026-10-01
    Bone Turnover Markers TestingOscar Health2026-10-01
    Testosterone — Coverage Criteria for Measurement and MonitoringOscar Health2026-10-01
    Diabetes Mellitus Testing — Coverage CriteriaOscar Health2026-10-01
    Thyroid Disease TestingOscar Health2026-10-01
    Thyroid Disease Testingblue cross blue shield - louisiana2026-09-15
    Thyroid Disease TestingBlue Cross Blue Shield - New Mexico2026-09-04
    Parathyroid Hormone, Phosphorous, Calcium and Magnesium TestingBlue Cross Blue Shield - New Mexico2026-09-04
    Testosterone laboratory testing and managementPremera Bluecross2026-09-04

    Related Codes

    CPT-82009-KETONE-BODIES-QUALITATIVE-TEST

    CPT 82009: Qualitative Ketone Bodies Test

    CPT-82010-QUANTITATIVE-KETONE-BODIES-ASSAY-SERUM-PLASMA

    CPT 82010: Quantitative Ketone Bodies in Serum or Plasma

    CPT-82013-ACETYLCHOLINESTERASE-QUANTITATIVE-ASSAY

    CPT 82013: Quantitative Acetylcholinesterase (Acetylhydrolase) Assay

    CPT-82016-QUALITATIVE-ACYLCARNITINES-METABOLIC-SCREEN

    CPT 82016: Qualitative Acylcarnitines, Plasma/Serum/Urine

    CPT-82017-QUANTITATIVE-ACYLCARNITINE-ANALYSIS

    CPT 82017: Quantitative Acylcarnitine Analysis

    CPT-82024-QUANTITATIVE-CORTICOTROPIN-ACTH-ASSAY

    CPT 82024: Adrenocorticotropic Hormone (ACTH) Quantitative Assay

    CPT-82030-QUANTITATIVE-CAMP-PLASMA-URINE-ASSAY

    CPT 82030: Quantitative cyclic AMP assay on plasma or urine

    CPT-82040-QUANTITATIVE-ALBUMIN-MEASUREMENT

    CPT 82040: Quantitative Albumin Measurement

    CPT-82042-QUANTITATIVE-ALBUMIN-NONBLOOD-FLUID

    CPT 82042: Albumin Quantitation in Non-Blood Body Fluid

    CPT-82043-URINE-ALBUMIN-QUANTITATION-KIDNEY-DISEASE

    CPT 82043: Urine Albumin Quantitative Assay

    Showing 1–10 of 411

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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