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CPT 82172: Apolipoprotein Testing of Lipoprotein Components
CPT code 82172 represents laboratory measurement of apolipoproteins within lipoprotein complexes, including key analytes such as Apo-A1, Apo-B, and Apo-E. These assays provide clinically relevant information about lipid particle composition that can inform cardiovascular risk stratification and management of dyslipidemia. As precision lipid testing grows, apolipoprotein measurement has national relevance for laboratory clinical services, payer coverage policies, and diagnostic workflows.
Key payers in the coverage landscape include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of clinical context and typical sites of service, plus discussion of payer considerations and common billing modifiers used with laboratory CPT codes. The publication furnishes benchmarks where available, summarizes relevant coding relationships, and highlights operational implications for laboratories and billing teams.
This summary is intended for national audiences including laboratory directors, billing managers, clinicians who order lipid testing, and payer policy analysts. Data not available in the input is noted where applicable; the focus remains on clinical meaning, service setting, and how the code is used in routine laboratory practice.
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Billing Code Overview
CPT code 82172 describes apolipoprotein testing performed by a laboratory analyst to measure apolipoproteins associated with lipoprotein complexes, most notably Apo-A1, Apo-B, and Apo-E. The test evaluates protein components of high-, low-, and very-low–density lipoproteins to support assessment of lipid-related cardiovascular risk and related metabolic conditions.
Service Type: Laboratory — Clinical Pathology / Chemistry
Typical Site of Service: Clinical laboratory or hospital laboratory