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    v1.0.28
    OpenPayerBilling CodesChemistry ProceduresCPT cpt-82382-urine-total-catecholamines-quantitative
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    CPT 82382: Urine Total Catecholamines, Quantitative

    CPT code 82382 reports a laboratory assay measuring total urine catecholamines (epinephrine, norepinephrine, dopamine) as a clinical test for evaluating catecholamine secretion; the service is a clinical laboratory diagnostic test typically performed in a laboratory or outpatient collection setting with specimen collection from urine and analytic measurement by the lab analyst.

    For related coverage guidance, see recent payer policy updates: Salivary Hormone Testing, Parathyroid Hormone, Phosphorus, Calcium, and Magnesium Testing, Bone Turnover Markers Testing.

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    Table of contents

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    • Billing CodesCPT, HCPCS, DRG & more
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    Clinical & Coding Specifications

    Clinical Context

    A 45-year-old patient presents with episodic headaches, sweating, palpitations, and sustained or paroxysmal hypertension. The clinician suspects a catecholamine-secreting tumor (pheochromocytoma or paraganglioma) or autonomic dysfunction. The outpatient workflow begins with history, physical exam, and office blood pressure monitoring. The clinician orders a 24-hour urine collection for total catecholamines (82382) to measure urinary epinephrine, norepinephrine, and dopamine levels. The patient receives written collection instructions, stops interfering medications if clinically safe, and collects all urine over 24 hours in a provided container with preservative as indicated. The specimen is transported to the central clinical laboratory; a medical technologist or laboratory analyst performs the assay and reports quantitative total catecholamine results to the ordering provider. Results are reviewed in conjunction with plasma catecholamine or metanephrine testing, imaging studies, and clinical findings to guide diagnosis and further management.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    80053Comprehensive metabolic panel; 14 testsPre-procedural metabolic evaluation often ordered concurrently to assess renal function and electrolytes prior to urine collection or imaging

    82150 | Assay of catecholamines (epinephrine, norepinephrine) in plasma or urine, quantitative | Alternate or supplemental testing; labs may report specific catecholamine assays in addition to total catecholamines

    82542 | Amino acids; tryptophan, or related assays (example metabolic) | Ordered in differential metabolic evaluations when broader biochemical testing is indicated

    83912 | Assay of metanephrines, fractionated, plasma or urine | Common complementary test; plasma or urine fractionated metanephrines are frequently used alongside total catecholamines to evaluate for pheochromocytoma

    99000 | Handling and/or conveyance of specimen (e.g., transportation fee) | Facility or courier charges associated with specimen transport from collection site to the reference laboratory

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    208000000XPediatrics PhysicianA pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
    207K00000XAllergy & Immunology PhysicianAn allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
    207ZC0500XCytopathology PhysicianA cytopathologist is an anatomic pathologist trained in the diagnosis of human disease by means of the study of cells obtained from body secretions an…
    251300000XLocal Education Agency (LEA)The term local education agency means a public board of education or other public authority legally constituted within a State to either provide admin…
    363LG0600XGerontology Nurse PractitionerPhysician Assistants & Advanced Practice Nursing Providers · Nurse Practitioner
    3336C0003XCommunity/Retail PharmacyA pharmacy where pharmacists store, prepare, and dispense medicinal preparations and/or prescriptions for a local patient population in accordance wit…

    Related ICD-10-CM Codes

    27 rows

    ICD-10-CM CodeDescription
    C74.90Malignant neoplasm of unspecified part of unspecified adrenal gland
    C74.91Malignant neoplasm of unspecified part of right adrenal gland
    D44.4Neoplasm of uncertain behavior of craniopharyngeal duct
    E03.9Hypothyroidism, unspecified
    E11.9Type 2 diabetes mellitus without complications
    E21.3Hyperparathyroidism, unspecified
    E27.5Adrenomedullary hyperfunction
    E30.9Disorder of puberty, unspecified
    E34.9Endocrine disorder, unspecified
    E78.5Hyperlipidemia, unspecified

    Showing 1–10 of 27

    Related Payer Policy Updates

    Specialty: Endocrinology1 / 3

    10 rows

    PolicyPayerEffective Date
    Salivary Hormone TestingOscar Health2026-10-01
    Parathyroid Hormone, Phosphorus, Calcium, and Magnesium TestingOscar Health2026-10-01
    Bone Turnover Markers TestingOscar Health2026-10-01
    Testosterone — Coverage Criteria for Measurement and MonitoringOscar Health2026-10-01
    Diabetes Mellitus Testing — Coverage CriteriaOscar Health2026-10-01
    Thyroid Disease TestingOscar Health2026-10-01
    Thyroid Disease Testingblue cross blue shield - louisiana2026-09-15
    Thyroid Disease TestingBlue Cross Blue Shield - New Mexico2026-09-04
    Parathyroid Hormone, Phosphorous, Calcium and Magnesium TestingBlue Cross Blue Shield - New Mexico2026-09-04
    Testosterone laboratory testing and managementPremera Bluecross2026-09-04

    Related Codes

    CPT-82009-KETONE-BODIES-QUALITATIVE-TEST

    CPT 82009: Qualitative Ketone Bodies Test

    CPT-82010-QUANTITATIVE-KETONE-BODIES-ASSAY-SERUM-PLASMA

    CPT 82010: Quantitative Ketone Bodies in Serum or Plasma

    CPT-82013-ACETYLCHOLINESTERASE-QUANTITATIVE-ASSAY

    CPT 82013: Quantitative Acetylcholinesterase (Acetylhydrolase) Assay

    CPT-82016-QUALITATIVE-ACYLCARNITINES-METABOLIC-SCREEN

    CPT 82016: Qualitative Acylcarnitines, Plasma/Serum/Urine

    CPT-82017-QUANTITATIVE-ACYLCARNITINE-ANALYSIS

    CPT 82017: Quantitative Acylcarnitine Analysis

    CPT-82024-QUANTITATIVE-CORTICOTROPIN-ACTH-ASSAY

    CPT 82024: Adrenocorticotropic Hormone (ACTH) Quantitative Assay

    CPT-82030-QUANTITATIVE-CAMP-PLASMA-URINE-ASSAY

    CPT 82030: Quantitative cyclic AMP assay on plasma or urine

    CPT-82040-QUANTITATIVE-ALBUMIN-MEASUREMENT

    CPT 82040: Quantitative Albumin Measurement

    CPT-82042-QUANTITATIVE-ALBUMIN-NONBLOOD-FLUID

    CPT 82042: Albumin Quantitation in Non-Blood Body Fluid

    CPT-82043-URINE-ALBUMIN-QUANTITATION-KIDNEY-DISEASE

    CPT 82043: Urine Albumin Quantitative Assay

    Showing 1–10 of 411

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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