Summary & Overview
CPT 82670: Total Estradiol Quantitative Assay
CPT code 82670 identifies a quantitative laboratory assay for total estradiol, typically performed by clinical laboratories using methods such as LC–MS/MS. Measuring estradiol is central to evaluating reproductive endocrine function, monitoring fertility treatments, and assessing hormonal disorders in both women and men. Nationally, reliable estradiol measurement supports clinical decision-making across primary care, obstetrics–gynecology, reproductive endocrinology, and inpatient settings.
Key payers addressed include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. The publication covers payer coverage considerations and common clinical contexts in which 82670 is billed. Readers will find a concise explanation of the test, typical sites of service, and the clinical scenarios that commonly prompt ordering of total estradiol. The report also outlines benchmark relationships to related services — for example, panels that require multiple estradiol assays — and highlights operational and coding considerations relevant to laboratories and clinicians.
This summary is intended for a national audience of laboratory managers, coding and billing professionals, and clinicians seeking clarity on the clinical role and billing identity of CPT code 82670. Data not available in the input for payer-specific rates or utilization metrics are not included.
Billing Code Overview
CPT code 82670 reports a laboratory assay measuring total estradiol in a biological specimen using methods such as liquid chromatography–tandem mass spectrometry (LC–MS/MS). This test quantifies circulating estradiol, an estrogenic hormone important for assessing hormonal status in both female and male patients.
Service type: Laboratory test — quantitative estradiol measurement
Typical site of service: Clinical laboratory or hospital laboratory, with specimens commonly collected in outpatient blood-draw settings or inpatient phlebotomy
Clinical & Coding Specifications
Clinical Context
A 38‑year‑old woman presents to an endocrinology clinic with progressive weight gain, easy bruising, menstrual irregularity, and recent hypertension. The clinician orders a serum total estradiol measured by liquid chromatography–tandem mass spectrometry (CPT 82670) to quantify baseline estrogen levels as part of an endocrine workup for suspected adrenal or pituitary dysfunction and to assess ovarian contribution to hypercortisolemia. Blood is drawn in the outpatient phlebotomy area, labeled, and sent to the Clinical Medical Laboratory for analysis. The lab performs CPT 82670 using LC–MS/MS, providing a sensitive and specific estradiol concentration to inform differential diagnosis among E24.0–E24.9 and other adrenal disorders. Results are reported to the ordering provider and integrated with cortisol, ACTH, and other hormonal assays to guide diagnostic interpretation and subsequent management steps such as dynamic endocrine testing or referral to Obstetrics & Gynecology or Family Medicine for fertility counseling or perioperative planning.
Coding Specifications
| Modifier | Description | When to Use |
|---|---|---|
26 | Professional component |