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CPT 82670: Total Estradiol Quantitative Assay
CPT code 82670 identifies a quantitative laboratory assay for total estradiol, typically performed by clinical laboratories using methods such as LC–MS/MS. Measuring estradiol is central to evaluating reproductive endocrine function, monitoring fertility treatments, and assessing hormonal disorders in both women and men. Nationally, reliable estradiol measurement supports clinical decision-making across primary care, obstetrics–gynecology, reproductive endocrinology, and inpatient settings.
Key payers addressed include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. The publication covers payer coverage considerations and common clinical contexts in which 82670 is billed. Readers will find a concise explanation of the test, typical sites of service, and the clinical scenarios that commonly prompt ordering of total estradiol. The report also outlines benchmark relationships to related services — for example, panels that require multiple estradiol assays — and highlights operational and coding considerations relevant to laboratories and clinicians.
This summary is intended for a national audience of laboratory managers, coding and billing professionals, and clinicians seeking clarity on the clinical role and billing identity of CPT code 82670. Data not available in the input for payer-specific rates or utilization metrics are not included.
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Billing Code Overview
CPT code 82670 reports a laboratory assay measuring total estradiol in a biological specimen using methods such as liquid chromatography–tandem mass spectrometry (LC–MS/MS). This test quantifies circulating estradiol, an estrogenic hormone important for assessing hormonal status in both female and male patients.
Service type: Laboratory test — quantitative estradiol measurement
Typical site of service: Clinical laboratory or hospital laboratory, with specimens commonly collected in outpatient blood-draw settings or inpatient phlebotomy
National Reimbursement Benchmarks
For CPT 82670, BUCA’s average commercial rate sits at $55.6, representing the broad-market midpoint for commercial payers in this sample. Blue Cross Blue Shield is above BUCA with a mean of $75.4 and shows substantial dispersion between the 25th and 75th percentiles ($56.7 to $90.9), a P75–P25 spread of $34.2 indicating wider variability in negotiated prices. Aetna and Cigna have mean rates below BUCA at $33.9 and $28.7 respectively; Aetna’s interquartile spread is $14.4 (P75 $37.4 minus P25 $21.0), while Cigna’s spread is $24.7 (P75 $39.7 minus P25 $15.0). UnitedHealth Group’s mean of $25.0 pairs with the tightest interquartile range of $16.5 (P75 $27.9 minus P25 $12.4), suggesting more consistency.
Comparing dispersion across payers, Blue Cross Blue Shield displays the widest IQR at $34.2, reflecting the greatest variability among commercial contracts here. Cigna follows with a notable $24.7 spread, while UnitedHealth Group is the tightest at $16.5, and Aetna is relatively narrow at $16.4. BUCA’s quartiles ($39.3, $47.8, $67.0) give an IQR of $27.7, placing it between the wider BCBS and the tighter UnitedHealth Group and Aetna spreads, and illustrating that average commercial rates fall in the mid-range of observed payer variability.