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    v1.0.28
    OpenPayerBilling CodesChemistry ProceduresCPT cpt-82136-quantitative-2-to-5-amino-acid-analysis
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    CPT 82136: Quantitative Analysis of 2–5 Amino Acids

    CPT code 82136 describes quantitative laboratory testing for 2 to 5 amino acids on specimens such as blood, plasma, urine, or other body fluids, used to determine whether amino acid concentrations are outside normal limits; the service is a quantitative amino acid analysis typically performed by a laboratory or clinical chemistry service and usually provided in clinical laboratory or hospital laboratory settings.

    For related coverage guidance, see recent payer policy updates: Diabetic Supplies, Radiofrequency Ablation for Thyroid Nodules, Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Idaho Only).

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    Clinical & Coding Specifications

    Clinical Context

    A pediatric or adult patient presents for metabolic evaluation due to symptoms such as unexplained failure to thrive, developmental delay, hypotonia, unexplained vomiting, lethargy, or new-onset seizures. A clinician suspects an inborn error of amino acid metabolism (for example, phenylketonuria, maple syrup urine disease, or hyperammonemia-related disorders) or needs to monitor amino acid levels for nutritional assessment or toxicology. A blood (plasma/serum) or urine specimen is collected in the outpatient clinic, emergency department, or inpatient ward and sent to the clinical chemistry or biochemical genetics laboratory.

    The laboratory analyst performs quantitative amino acid analysis on the specimen, measuring 2 to 5 amino acids using methods such as ion-exchange chromatography, HPLC, or mass spectrometry. Results are reviewed for values outside reference ranges and reported to the ordering provider. Abnormal panels prompt further testing, specialty referral (e.g., to genetics or metabolic nutrition), or urgent clinical interventions if life-threatening metabolic derangements are detected.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    82043Drug, ethanol, qualitative; urineOrdered when evaluating toxic ingestion or substance exposure that may present with metabolic symptoms
    82045Drug; quantitative, other than ethanol, each specimenMay be used alongside metabolic testing if toxicology is a concern
    84132Ammonia; quantitativePerformed when amino acid abnormalities suggest hyperammonemia; important for metabolic workup
    80053Comprehensive metabolic panel; 14 testsOften ordered concurrently to assess electrolytes, renal and hepatic function that impact amino acid metabolism
    80299Toxicology procedure, not otherwise classifiedUsed for specialized toxicology tests that may accompany metabolic evaluations

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    208D00000XGeneral Practice PhysicianA physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    261QX0203XRadiation Oncology Clinic/CenterAmbulatory Health Care Facilities · Clinic/Center
    2080S0012XPediatric Sleep Medicine PhysicianA Pediatrician who practices Sleep Medicine is certified in the subspecialty of sleep medicine and specializes in the clinical assessment, physiologic…
    261QR0405XSubstance Use Disorder Rehabilitation Clinic/CenterAmbulatory Health Care Facilities · Clinic/Center
    204R00000XElectrodiagnostic Medicine PhysicianElectrodiagnostic medicine is the medical subspecialty that applies neurophysiologic techniques to diagnose, evaluate, and treat patients with impairm…
    343800000XSecured Medical Transport (VAN)A public or privately owned transportation service with vehicles, specially equipped to provide enhanced safety, security and passenger restraint, and…

    Related ICD-10-CM Codes

    18 rows

    ICD-10-CM CodeDescription
    E70.0Classical phenylketonuria
    E70.1Other hyperphenylalaninemias
    E71.0Maple-syrup-urine disease
    E71.2Disorder of branched-chain amino-acid metabolism, unspecified
    E73.9Lactose intolerance, unspecified
    E74.4Disorders of pyruvate metabolism and gluconeogenesis
    E74.9Disorder of carbohydrate metabolism, unspecified
    E78.5Hyperlipidemia, unspecified
    E83.39Other disorders of phosphorus metabolism
    E83.40Disorders of magnesium metabolism, unspecified

    Showing 1–10 of 18

    Related Payer Policy Updates

    Specialty: Endocrinology1 / 3

    10 rows

    PolicyPayerEffective Date
    Diabetic SuppliesCigna2026-10-15
    Radiofrequency Ablation for Thyroid NodulesCigna2026-10-15
    Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Idaho Only)UnitedHealthcare2026-10-01
    Tzield (teplizumab-mzwv) CoverageUnitedHealthcare2026-10-01
    Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Indiana Only)UnitedHealthcare2026-10-01
    Medical Necessity Guidelines Insulin PumpsMass General Brigham Health Plan2026-10-01
    Medical Necessity Guidelines: Continuous Glucose MonitorsMass General Brigham Health Plan2026-10-01
    Continuous Glucose MonitoringAmbetter Nevada2026-10-01
    Salivary Hormone TestingOscar Health2026-10-01
    Parathyroid Hormone, Phosphorus, Calcium, and Magnesium TestingOscar Health2026-10-01

    Related Codes

    CPT-82009-KETONE-BODIES-QUALITATIVE-TEST

    CPT 82009: Qualitative Ketone Bodies Test

    CPT-82010-QUANTITATIVE-KETONE-BODIES-ASSAY-SERUM-PLASMA

    CPT 82010: Quantitative Ketone Bodies in Serum or Plasma

    CPT-82013-ACETYLCHOLINESTERASE-QUANTITATIVE-ASSAY

    CPT 82013: Quantitative Acetylcholinesterase (Acetylhydrolase) Assay

    CPT-82016-QUALITATIVE-ACYLCARNITINES-METABOLIC-SCREEN

    CPT 82016: Qualitative Acylcarnitines, Plasma/Serum/Urine

    CPT-82017-QUANTITATIVE-ACYLCARNITINE-ANALYSIS

    CPT 82017: Quantitative Acylcarnitine Analysis

    CPT-82024-QUANTITATIVE-CORTICOTROPIN-ACTH-ASSAY

    CPT 82024: Adrenocorticotropic Hormone (ACTH) Quantitative Assay

    CPT-82030-QUANTITATIVE-CAMP-PLASMA-URINE-ASSAY

    CPT 82030: Quantitative cyclic AMP assay on plasma or urine

    CPT-82040-QUANTITATIVE-ALBUMIN-MEASUREMENT

    CPT 82040: Quantitative Albumin Measurement

    CPT-82042-QUANTITATIVE-ALBUMIN-NONBLOOD-FLUID

    CPT 82042: Albumin Quantitation in Non-Blood Body Fluid

    CPT-82043-URINE-ALBUMIN-QUANTITATION-KIDNEY-DISEASE

    CPT 82043: Urine Albumin Quantitative Assay

    Showing 1–10 of 411

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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