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    v1.0.28
    OpenPayerBilling CodesChemistry ProceduresCPT cpt-84295-serum-plasma-whole-blood-sodium-measurement
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    CPT 84295: Serum Sodium Concentration Measurement

    CPT code 84295 describes a laboratory quantitative assay measuring sodium concentration in serum, plasma, or whole blood, typically performed as a clinical chemistry electrolyte test; the service type is laboratory diagnostic testing and the typical site of service is a clinical laboratory or hospital laboratory where blood specimens are analyzed for electrolyte evaluation.

    For related coverage guidance, see recent payer policy updates: Salivary Hormone Testing, Bone Turnover Markers Testing, Parathyroid Hormone, Phosphorus, Calcium, and Magnesium Testing.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 68-year-old male presents to the emergency department with weakness, confusion, and persistent vomiting. The treating clinician orders basic serum chemistries, including a serum sodium measurement, to assess for electrolyte disturbances that may explain altered mental status and volume status. A venous blood sample is collected and sent to the hospital core laboratory. The lab analyst performs the quantitative sodium assay (84295) using an automated chemistry analyzer. Results are verified by the laboratory information system, reviewed by clinical laboratory staff, and released to the ordering clinician electronically. The sodium result guides immediate management decisions such as intravenous fluid selection, hypertonic saline administration, or further electrolyte and endocrine evaluation. Typical site of service is an outpatient laboratory draw station, hospital outpatient department, inpatient hospital laboratory, or emergency department point-of-care collection with testing performed in the clinical laboratory.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    80048Basic metabolic panel (Calcium, total)Common panel that includes serum sodium as part of a multi-analyte metabolic evaluation; often ordered instead of individual sodium test.
    36415Collection of venous blood by venipuncturePreceding procedure for obtaining the specimen used for the sodium assay.
    80500Urinalysis, by dipstick or tablet reagent, non-automated, with microscopy when performedMay be ordered alongside serum sodium when evaluating volume status or renal function.
    84443Assay of thyroid stimulating hormone (TSH)Ordered in the workup of hyponatremia or metabolic disturbances that could affect sodium.
    95831Electroencephalogram (EEG), 21–30 minutes awake and drowsyIn select cases of altered mental status related to severe dysnatremia, neurologic monitoring may be performed; included to reflect potential downstream testing.

    Related Modifiers

    5 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    P1Modifier P1 indicates an ASA Physical Status I — a normal healthy patient — and is appended to anesthesia CPT codes (00100–01999) based on the anesthesiologist’s clinical assessment. It documents the…- When to apply: Use modifier P1 on anesthesia CPT codes (00100–01999) when the anesthesia provider assigns ASA Physical Status I — a normal healthy patient (non‑smoker, minimal or no alcohol use).…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207RC0000XCardiovascular Disease PhysicianAn internist who specializes in diseases of the heart and blood vessels and manages complex cardiac conditions such as heart attacks and life-threaten…
    208D00000XGeneral Practice PhysicianA physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
    208000000XPediatrics PhysicianA pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
    261QM3000XMedically Fragile Infants and Children Day CareAn entity, facility, or distinct part of a facility specially equipped and staffed to provide care for medically fragile children with varied and comp…
    1835P1300XPsychiatric PharmacistA licensed pharmacist who has demonstrated specialized knowledge and skill in optimizing care of patients with psychiatric illness by assessing and mo…
    2083P0901XPublic Health & General Preventive Medicine PhysicianPublic health and general preventive medicine focuses on promoting health, preventing disease, and managing the health of communities and defined popu…
    261QB0400XBirthing Clinic/CenterA freestanding birth center is a health facility other than a hospital where childbirth is planned to occur away from the pregnant woman's residence, …
    132700000XDietary ManagerA dietary manager is a trained food services professional who is charged with maintaining cost/profit objectives, purchasing foods and services for th…

    Related Payer Policy Updates

    Specialty: Endocrinology1 / 3

    5 rows

    PolicyPayerEffective Date
    Salivary Hormone TestingOscar Health2026-10-01
    Bone Turnover Markers TestingOscar Health2026-10-01
    Parathyroid Hormone, Phosphorus, Calcium, and Magnesium TestingOscar Health2026-10-01
    Testosterone — Coverage Criteria for Measurement and MonitoringOscar Health2026-10-01
    Thyroid Disease TestingOscar Health2026-10-01

    Related Codes

    CPT-82009-KETONE-BODIES-QUALITATIVE-TEST

    CPT 82009: Qualitative Ketone Bodies Test

    CPT-82010-QUANTITATIVE-KETONE-BODIES-ASSAY-SERUM-PLASMA

    CPT 82010: Quantitative Ketone Bodies in Serum or Plasma

    CPT-82013-ACETYLCHOLINESTERASE-QUANTITATIVE-ASSAY

    CPT 82013: Quantitative Acetylcholinesterase (Acetylhydrolase) Assay

    CPT-82016-QUALITATIVE-ACYLCARNITINES-METABOLIC-SCREEN

    CPT 82016: Qualitative Acylcarnitines, Plasma/Serum/Urine

    CPT-82017-QUANTITATIVE-ACYLCARNITINE-ANALYSIS

    CPT 82017: Quantitative Acylcarnitine Analysis

    CPT-82024-QUANTITATIVE-CORTICOTROPIN-ACTH-ASSAY

    CPT 82024: Adrenocorticotropic Hormone (ACTH) Quantitative Assay

    CPT-82030-QUANTITATIVE-CAMP-PLASMA-URINE-ASSAY

    CPT 82030: Quantitative cyclic AMP assay on plasma or urine

    CPT-82040-QUANTITATIVE-ALBUMIN-MEASUREMENT

    CPT 82040: Quantitative Albumin Measurement

    CPT-82042-QUANTITATIVE-ALBUMIN-NONBLOOD-FLUID

    CPT 82042: Albumin Quantitation in Non-Blood Body Fluid

    CPT-82043-URINE-ALBUMIN-QUANTITATION-KIDNEY-DISEASE

    CPT 82043: Urine Albumin Quantitative Assay

    Showing 1–10 of 411

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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