CPT code 82105 represents a quantitative laboratory assay for alpha–fetoprotein (AFP), a fetal glycoprotein that can be elevated in certain malignancies and liver disorders when measured later in life. This test supports diagnostic evaluation, oncology monitoring, and prenatal screening in clinical practice. Nationally, AFP measurement is an established laboratory service with implications for cancer surveillance and maternal-fetal medicine, making accurate coding essential for clinical workflows and claims processing.

Key payers in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of clinical context, typical sites of service, and which payers commonly reimburse AFP testing. The publication summarizes standard billing considerations, common modifier usage listed for this code, and contextual clinical applications of AFP measurement.

This summary equips clinicians, laboratory administrators, and billing professionals with a clear description of CPT code 82105, the clinical scenarios in which the test is used, and the payer landscape to expect for routine claims submission. Data not available in the input will be noted where applicable in other sections.