CPT code 81528 describes a laboratory test that analyzes a stool sample performing fecal hemoglobin measurement and real-time amplification of 10 DNA markers, then applies an algorithmic analysis of the lab results and patient data to report a positive or negative colon cancer screening result; the service is a molecular stool-based colorectal cancer screening and typically involves clinical laboratory technical processing performed in a clinical laboratory or reference lab setting rather than an outpatient clinic or procedural suite.

For related coverage guidance, see recent payer policy updates: RTM Testing of Homocysteine Metabolism-Related Conditions, Multimarker Serum Testing Related to Ovarian Cancer, Genomic Profiling for Selecting Targeted Cancer Therapies.