Loading...

    Explore
    • Policy Monitoring
    • Live Policy Feed
    • Billing Codes
    • NPI Medicare & Medicaid
    • Healthcare Providers
    • Health Insurance Payers
    • States
    • Service Lines
    • Taxonomy Codes
    Lookup tools
    • Billing Code Lookup
    • CPT Modifier Lookup
    • Provider Taxonomy Code Lookup
    • Healthcare Provider & Facility Lookup
    • Health Insurance Payer Lookup
    • Payer Contact Directory

    Policy & Benchmark Tools

    • Prior Authorization Lookup
    • Coverage Criteria Lookup
    • Timely Filing Lookup
    • Billing Code Reimbursement Rates
    • Payer Comparison Dashboard
    • Facility Comparison Dashboard
    • All tools

    Company

    • About OpenPayer
    • Data Sources
    • Trek Health
    OpenPayerby Trek Health
    LinkedInYouTube

    © 2026 Trek Health. All rights reserved.

    OpenPayer is built and maintained by Trek Health.

    v1.0.30
    OpenPayerBilling CodesMultianalyte Assays with Algorithmic AnalysesCPT cpt-81507-nips-cell-free-dna-trisomy-risk-analysis
    Ask Trek AI about this page

    CPT 81507: Noninvasive Prenatal Testing for Trisomies 13, 18, 21

    CPT code 81507 describes a noninvasive prenatal screening laboratory service in which a lab analyst performs microassay testing on maternal plasma and runs an algorithmic analysis of patient data and test results to generate patient-specific risk scores for fetal trisomies 13, 18, and 21; service type: noninvasive prenatal screening with molecular microassay and algorithmic analysis; typical site of service: clinical laboratory or reference laboratory (maternal-fetal medicine/lab testing environment).

    For related coverage guidance, see recent payer policy updates: Oral Cancer Screening and Testing, RTM Testing for Alpha-1 Antitrypsin Deficiency, Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policy.

    Customize your policy alerts

    Sign up for cpt 81507 policy alerts

    Get alerted when payer policies referencing 81507 are released or updated.

    Monitor payer policy activity

    Receive email alerts as soon as relevant payer policies are published or updated.

    Table of contents

    Progress1 / 7

    Explore openpayer tools

    • Billing CodesCPT, HCPCS, DRG & more
    • Reimbursement RatesCommercial vs. Medicare rate reports
    • Facility ComparisonBeds, revenue & payer mix
    • ProvidersHospitals & facilities
    • PayersPlans & market footprint
    • Taxonomy CodesNUCC specialty codes
    • ModifiersCPT modifiers & usage
    • Prior AuthorizationPA policies by payer & drug
    • Timely FilingFiling deadlines by payer
    • Coverage CriteriaMedical necessity by payer
    • Payer ContactsClaims, PA & appeals contacts
    View all tools

    Clinical & Coding Specifications

    Clinical Context

    A 34-year-old pregnant patient at 10–22 weeks gestation presents for prenatal screening after routine obstetric counseling. The clinician orders a maternal plasma cell-free DNA (cfDNA) noninvasive prenatal screening test to assess risk for fetal trisomy 13, trisomy 18, and trisomy 21. A phlebotomy draw is performed in the outpatient obstetrics clinic or an affiliated laboratory collection center; the specimen is sent to a reference laboratory where a molecular lab analyst performs microassay testing and algorithmic analysis of fetal cfDNA present in maternal plasma. The lab generates and reports a patient-specific risk score for each trisomy to the ordering provider. Typical sites of service are outpatient obstetrics/gynecology clinics, prenatal diagnostic centers, and independent clinical reference laboratories. The clinical workflow includes patient counseling, informed consent for prenatal screening, specimen collection and shipment, laboratory analytic processing (sequencing or microassay), bioinformatic algorithmic interpretation, and result reporting to the ordering clinician for follow-up counseling and possible diagnostic testing (e.g., chorionic villus sampling or amniocentesis) if high risk is reported.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    81025Urinalysis; automated with microscopyPerformed at initial prenatal visit to assess maternal health prior to screening; not directly part of cfDNA testing but commonly ordered in the same prenatal workup.
    36415Collection of venous blood by venipunctureThe specimen collection procedure used to obtain maternal plasma for cfDNA testing.
    89290Cell-free fetal DNA analysis (noninvasive prenatal testing) sequencing procedure, each chromosome targetedRelated molecular laboratory methodology codes sometimes billed for sequence-based cfDNA testing components when applicable.
    88367Microarray analysis, interpretation and reportIf a microarray-based platform is used for fetal chromosomal analysis, this code may be used for interpretation in certain lab billing scenarios.
    76942Ultrasonic guidance for needle placement (eg, amniocentesis)May be performed subsequently if a high-risk result prompts diagnostic invasive testing such as amniocentesis.
    59015Amniocentesis for chromosomal analysis; diagnostic samplingPerformed when cfDNA screening indicates high risk and confirmatory diagnostic testing is pursued.

    Related Modifiers

    5 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207Q00000X
    207L00000X
    207RH0000X
    207K00000X
    1744G0900X
    364SX0106X
    320900000X
    261QM2500X

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    O09.511Supervision of elderly primigravida, first trimester
    O09.512Supervision of elderly primigravida, second trimester
    O09.519Supervision of elderly primigravida, unspecified trimester
    O09.611Supervision of young primigravida, first trimester
    O09.612Supervision of young primigravida, second trimester
    O09.619Supervision of young primigravida, unspecified trimester
    O09.821Supervision of pregnancy with history of in utero procedure during previous pregnancy, first trimester
    O09.822Supervision of pregnancy with history of in utero procedure during previous pregnancy, second trimester
    O09.829Supervision of pregnancy with history of in utero procedure during previous pregnancy, unspecified trimester
    O09.891Supervision of other high risk pregnancies, first trimester

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Genetic & Molecular Testing1 / 3

    10 rows

    PolicyPayerEffective Date
    Oral Cancer Screening and TestingOscar Health2027-01-01
    RTM Testing for Alpha-1 Antitrypsin DeficiencyOscar Health2027-01-01
    Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policybcbsvermont2027-01-01
    Carrier Testing Panels for Genetic Diseases (for Kentucky Only)UnitedHealthcare2026-10-01
    Genetic Testing for Neurological Disorders (for Kansas Only)UnitedHealthcare2026-10-01
    Genetic and Molecular TestingProvidence Health Plan2026-10-01
    Cell-Free Fetal DNA Testing (for Idaho Only)UnitedHealthcare2026-10-01
    Next Generation Sequencing for Minimal Residual Disease DetectionProvidence Health Plan2026-10-01
    Pharmacogenetic Panel Testing (for Kansas Only)UnitedHealthcare2026-10-01
    Non-Covered Genetic Panel TestsProvidence Health Plan2026-10-01

    Related Codes

    CPT-81490-RA-DISEASE-ACTIVITY-SCORE-SERUM-BIOMARKER-PANEL

    CPT 81490: Serum Biomarker Panel and RA Disease Activity Score

    CPT-81493-CORONARY-ARTERY-DISEASE-23-GENE-RT-PCR-RISK-SCORE

    CPT 81493: 23-Gene RT-PCR Molecular Test With CAD Risk Score

    CPT-81500-CA125-HE4-ALGORITHMIC-RISK-SCORE

    CPT 81500: Algorithmic Risk Score Using CA-125 and HE4

    CPT-81503-ALGORITHMIC-LAB-RISK-SCORE-CA125-APOLIPOPROTEIN-A1

    CPT 81503: Algorithmic Risk Score from Multiple Lab Markers

    CPT-81504-TUMOR-ORIGIN-RNA-EXPRESSION-CLASSIFIER

    CPT 81504: Tumor RNA Expression Profile Comparison

    CPT-81506-DIABETES-BIOMARKER-PANEL-WITH-RISK-SCORE

    CPT 81506: Diabetes Risk Score from Biochemical Assays

    CPT-81508-PAPP-A-HCG-ALGORITHMIC-RISK-ASSAY

    CPT 81508: First-Trimester PAPP-A and hCG Risk Score

    CPT-81509-LAB-ALGORITHMIC-RISK-ASSESSMENT-PAPP-A-HCG-DIA

    CPT 81509: Prenatal Biochemical Risk Score from PAPP–A, hCG, DIA

    CPT-81510-PRENATAL-TRIPLE-MARKER-ALGORITHMIC-RISK-ASSESSMENT

    CPT 81510: Prenatal Serum Screening with Algorithmic Risk Score

    CPT-81511-MULTIANALYTE-SERUM-SCREENING-ALGORITHMIC-RISK-SCORE

    CPT 81511: Maternal Serum Quadruple Marker Risk Score

    Showing 1–10 of 41

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
    Published by

    Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

    Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.