CPT 81507: Noninvasive Prenatal Testing for Trisomies 13, 18, 21

CPT code 81507 describes a noninvasive prenatal screening laboratory service in which a lab analyst performs microassay testing on maternal plasma and runs an algorithmic analysis of patient data and test results to generate patient-specific risk scores for fetal trisomies 13, 18, and 21; service type: noninvasive prenatal screening with molecular microassay and algorithmic analysis; typical site of service: clinical laboratory or reference laboratory (maternal-fetal medicine/lab testing environment).

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CPT 81507: Noninvasive Prenatal Testing for Trisomies 13, 18, 21

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Get alerted when payer policies referencing 81507 are released or updated.

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Clinical & Coding Specifications

Clinical Context

A 34-year-old pregnant patient at 10–22 weeks gestation presents for prenatal screening after routine obstetric counseling. The clinician orders a maternal plasma cell-free DNA (cfDNA) noninvasive prenatal screening test to assess risk for fetal trisomy 13, trisomy 18, and trisomy 21. A phlebotomy draw is performed in the outpatient obstetrics clinic or an affiliated laboratory collection center; the specimen is sent to a reference laboratory where a molecular lab analyst performs microassay testing and algorithmic analysis of fetal cfDNA present in maternal plasma. The lab generates and reports a patient-specific risk score for each trisomy to the ordering provider. Typical sites of service are outpatient obstetrics/gynecology clinics, prenatal diagnostic centers, and independent clinical reference laboratories. The clinical workflow includes patient counseling, informed consent for prenatal screening, specimen collection and shipment, laboratory analytic processing (sequencing or microassay), bioinformatic algorithmic interpretation, and result reporting to the ordering clinician for follow-up counseling and possible diagnostic testing (e.g., chorionic villus sampling or amniocentesis) if high risk is reported.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`81025`	Urinalysis; automated with microscopy	Performed at initial prenatal visit to assess maternal health prior to screening; not directly part of cfDNA testing but commonly ordered in the same prenatal workup.
`36415`	Collection of venous blood by venipuncture	The specimen collection procedure used to obtain maternal plasma for cfDNA testing.
`89290`	Cell-free fetal DNA analysis (noninvasive prenatal testing) sequencing procedure, each chromosome targeted	Related molecular laboratory methodology codes sometimes billed for sequence-based cfDNA testing components when applicable.
`88367`	Microarray analysis, interpretation and report	If a microarray-based platform is used for fetal chromosomal analysis, this code may be used for interpretation in certain lab billing scenarios.
`76942`	Ultrasonic guidance for needle placement (eg, amniocentesis)	May be performed subsequently if a high-risk result prompts diagnostic invasive testing such as amniocentesis.
`59015`	Amniocentesis for chromosomal analysis; diagnostic sampling	Performed when cfDNA screening indicates high risk and confirmatory diagnostic testing is pursued.

Related Modifiers

5 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
90	Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…	- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207Q00000X	Family Medicine Physician	Family Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
207RH0000X	Hematology (Internal Medicine) Physician	An internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
207K00000X	Allergy & Immunology Physician	An allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
1744G0900X	Graphics Designer	Other Service Providers · Specialist
364SX0106X	Occupational Health Clinical Nurse Specialist	Physician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist
320900000X	Intellectual and/or Developmental Disabilities Community Based Residential Treatment Facility	A home-like residential facility providing habilitation, support and monitoring services to individuals diagnosed with intellectual and/or development…
261QM2500X	Medical Specialty Clinic/Center	An entity, facility, or distinct part of a facility providing diagnostic, treatment, and prescriptive services related to a specific area of medical s…

Related ICD-10-CM Codes

26 rows

ICD-10-CM Code	Description
O09.511	Supervision of elderly primigravida, first trimester
O09.512	Supervision of elderly primigravida, second trimester
O09.519	Supervision of elderly primigravida, unspecified trimester
O09.611	Supervision of young primigravida, first trimester
O09.612	Supervision of young primigravida, second trimester
O09.619	Supervision of young primigravida, unspecified trimester
O09.821	Supervision of pregnancy with history of in utero procedure during previous pregnancy, first trimester
O09.822	Supervision of pregnancy with history of in utero procedure during previous pregnancy, second trimester
O09.829	Supervision of pregnancy with history of in utero procedure during previous pregnancy, unspecified trimester
O09.891	Supervision of other high risk pregnancies, first trimester

Showing 1–10 of 26

CPT 81490: Serum Biomarker Panel and RA Disease Activity Score

CPT-81493-CORONARY-ARTERY-DISEASE-23-GENE-RT-PCR-RISK-SCORE

CPT 81493: 23-Gene RT-PCR Molecular Test With CAD Risk Score

CPT-81500-CA125-HE4-ALGORITHMIC-RISK-SCORE

CPT 81500: Algorithmic Risk Score Using CA-125 and HE4

CPT-81503-ALGORITHMIC-LAB-RISK-SCORE-CA125-APOLIPOPROTEIN-A1

CPT 81503: Algorithmic Risk Score from Multiple Lab Markers

CPT-81504-TUMOR-ORIGIN-RNA-EXPRESSION-CLASSIFIER

CPT 81504: Tumor RNA Expression Profile Comparison

CPT-81506-DIABETES-BIOMARKER-PANEL-WITH-RISK-SCORE

CPT 81506: Diabetes Risk Score from Biochemical Assays

CPT-81508-PAPP-A-HCG-ALGORITHMIC-RISK-ASSAY

CPT 81508: First-Trimester PAPP-A and hCG Risk Score

CPT-81509-LAB-ALGORITHMIC-RISK-ASSESSMENT-PAPP-A-HCG-DIA

CPT 81509: Prenatal Biochemical Risk Score from PAPP–A, hCG, DIA

CPT-81510-PRENATAL-TRIPLE-MARKER-ALGORITHMIC-RISK-ASSESSMENT

CPT 81510: Prenatal Serum Screening with Algorithmic Risk Score

CPT-81511-MULTIANALYTE-SERUM-SCREENING-ALGORITHMIC-RISK-SCORE

CPT 81511: Maternal Serum Quadruple Marker Risk Score

Showing 1–10 of 41

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`81025`	Urinalysis; automated with microscopy	Performed at initial prenatal visit to assess maternal health prior to screening; not directly part of cfDNA testing but commonly ordered in the same prenatal workup.
`36415`	Collection of venous blood by venipuncture	The specimen collection procedure used to obtain maternal plasma for cfDNA testing.
`89290`	Cell-free fetal DNA analysis (noninvasive prenatal testing) sequencing procedure, each chromosome targeted	Related molecular laboratory methodology codes sometimes billed for sequence-based cfDNA testing components when applicable.
`88367`	Microarray analysis, interpretation and report	If a microarray-based platform is used for fetal chromosomal analysis, this code may be used for interpretation in certain lab billing scenarios.
`76942`	Ultrasonic guidance for needle placement (eg, amniocentesis)	May be performed subsequently if a high-risk result prompts diagnostic invasive testing such as amniocentesis.
`59015`	Amniocentesis for chromosomal analysis; diagnostic sampling	Performed when cfDNA screening indicates high risk and confirmatory diagnostic testing is pursued.

Related Modifiers

5 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
90	Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…	- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
53	Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…	- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207Q00000X	Family Medicine Physician	Family Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
207RH0000X	Hematology (Internal Medicine) Physician	An internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
207K00000X	Allergy & Immunology Physician	An allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
1744G0900X	Graphics Designer	Other Service Providers · Specialist
364SX0106X	Occupational Health Clinical Nurse Specialist	Physician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist
320900000X	Intellectual and/or Developmental Disabilities Community Based Residential Treatment Facility	A home-like residential facility providing habilitation, support and monitoring services to individuals diagnosed with intellectual and/or development…
261QM2500X	Medical Specialty Clinic/Center	An entity, facility, or distinct part of a facility providing diagnostic, treatment, and prescriptive services related to a specific area of medical s…

Related ICD-10-CM Codes

26 rows

ICD-10-CM Code	Description
O09.511	Supervision of elderly primigravida, first trimester
O09.512	Supervision of elderly primigravida, second trimester
O09.519	Supervision of elderly primigravida, unspecified trimester
O09.611	Supervision of young primigravida, first trimester
O09.612	Supervision of young primigravida, second trimester
O09.619	Supervision of young primigravida, unspecified trimester
O09.821	Supervision of pregnancy with history of in utero procedure during previous pregnancy, first trimester
O09.822	Supervision of pregnancy with history of in utero procedure during previous pregnancy, second trimester
O09.829	Supervision of pregnancy with history of in utero procedure during previous pregnancy, unspecified trimester
O09.891	Supervision of other high risk pregnancies, first trimester

Showing 1–10 of 26

CPT 81490: Serum Biomarker Panel and RA Disease Activity Score

CPT-81493-CORONARY-ARTERY-DISEASE-23-GENE-RT-PCR-RISK-SCORE

CPT 81493: 23-Gene RT-PCR Molecular Test With CAD Risk Score

CPT-81500-CA125-HE4-ALGORITHMIC-RISK-SCORE

CPT 81500: Algorithmic Risk Score Using CA-125 and HE4

CPT-81503-ALGORITHMIC-LAB-RISK-SCORE-CA125-APOLIPOPROTEIN-A1

CPT 81503: Algorithmic Risk Score from Multiple Lab Markers

CPT-81504-TUMOR-ORIGIN-RNA-EXPRESSION-CLASSIFIER

CPT 81504: Tumor RNA Expression Profile Comparison

CPT-81506-DIABETES-BIOMARKER-PANEL-WITH-RISK-SCORE

CPT 81506: Diabetes Risk Score from Biochemical Assays

CPT-81508-PAPP-A-HCG-ALGORITHMIC-RISK-ASSAY

CPT 81508: First-Trimester PAPP-A and hCG Risk Score

CPT-81509-LAB-ALGORITHMIC-RISK-ASSESSMENT-PAPP-A-HCG-DIA

CPT 81509: Prenatal Biochemical Risk Score from PAPP–A, hCG, DIA

CPT-81510-PRENATAL-TRIPLE-MARKER-ALGORITHMIC-RISK-ASSESSMENT

CPT 81510: Prenatal Serum Screening with Algorithmic Risk Score

CPT-81511-MULTIANALYTE-SERUM-SCREENING-ALGORITHMIC-RISK-SCORE

CPT 81511: Maternal Serum Quadruple Marker Risk Score

Showing 1–10 of 41

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

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CPT 81507: Noninvasive Prenatal Testing for Trisomies 13, 18, 21

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CPT 81507: Noninvasive Prenatal Testing for Trisomies 13, 18, 21

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

References

CPT 81507: Noninvasive Prenatal Testing for Trisomies 13, 18, 21

Sign up for cpt 81507 policy alerts

CPT 81507: Noninvasive Prenatal Testing for Trisomies 13, 18, 21

Sign up for cpt 81507 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What clinical service does CPT 81507 represent?

Where and how is the specimen for CPT 81507 typically collected and processed?

Which billing modifiers are commonly associated with CPT 81507 and when are they used?

What related CPT codes or downstream procedures should be considered in the care pathway for patients undergoing testing described by CPT 81507?

Which payers are mentioned for CPT 81507 and does the page provide specific coverage or reimbursement rates?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What clinical service does CPT 81507 represent?

Where and how is the specimen for CPT 81507 typically collected and processed?

Which billing modifiers are commonly associated with CPT 81507 and when are they used?

What related CPT codes or downstream procedures should be considered in the care pathway for patients undergoing testing described by CPT 81507?

Which payers are mentioned for CPT 81507 and does the page provide specific coverage or reimbursement rates?

References