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    v1.0.30
    OpenPayerBilling CodesMultianalyte Assays with Algorithmic AnalysesCPT cpt-81500-ca125-he4-algorithmic-risk-score
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    CPT 81500: Algorithmic Risk Score Using CA-125 and HE4

    CPT code 81500 covers a laboratory service in which the lab analyst performs technical tests for CA‑125 and HE4 and applies an algorithmic analysis combining patient data and test results to report a patient risk score; the service type is laboratory algorithmic risk assessment, typically performed in a clinical laboratory or hospital lab setting and reported as a discrete molecular/algorithmic test result for clinical decision support.

    For related coverage guidance, see recent payer policy updates: Oral Cancer Screening and Testing, RTM Testing for Alpha-1 Antitrypsin Deficiency, Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policy.

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    Clinical & Coding Specifications

    Clinical Context

    A 56-year-old woman with a pelvic mass and abnormal transvaginal ultrasound is seen in a gynecologic oncology clinic to evaluate risk for epithelial ovarian cancer. Her clinician orders serum biomarker testing for CA-125 and HE4, and sends the sample to a reference laboratory that performs the technical assays and applies an FDA-cleared algorithm combining the two markers with patient age and menopausal status to generate a numerical risk score. The laboratory analyst receives the specimen, performs immunoassays for CA-125 and HE4, verifies quality controls, enters patient demographic variables, runs the risk‑prediction algorithm, documents the technical results and algorithm output, and reports the patient risk score to the ordering provider via the laboratory information system. Results inform shared decision-making about further imaging, referral to gynecologic oncology, or surgical planning.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    81500CA-125 and HE4 algorithmic analysis to report patient risk score (technical lab testing and algorithm)Primary code describing the laboratory assay and algorithmic risk score generated from CA-125 and HE4.
    86304Immunoassay for tumor antigen, quantitative; multiple analytes (e.g., CA-125)Common laboratory method to measure CA-125 values that feed into the algorithm; may be billed by the performing lab.
    86255Immunoassay for tumor marker, quantitative; cancer antigen 125 (CA-125)Direct assay code often used for the individual CA-125 analyte measurement when reported separately.
    86301Immunoassay for tumor antigen, quantitative; single analyte (e.g., HE4)Method-level code for measuring HE4 when billed separately from the algorithmic report.
    99000Handling and/or conveyance of specimenAdministrative/handling codes used by some laboratories for specimen processing and transportation (payer-specific).

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207P00000X
    363L00000X
    364SA2100X
    2471S1302X
    2084D0003X
    103TP0814X
    207VB0002X
    253J00000X

    Related ICD-10-CM Codes

    27 rows

    ICD-10-CM CodeDescription
    C48.2Malignant neoplasm of peritoneum, unspecified
    C56.9Malignant neoplasm of unspecified ovary
    C57.9Malignant neoplasm of female genital organ, unspecified
    C76.2Malignant neoplasm of abdomen
    D49.9Neoplasm of unspecified behavior of unspecified site
    D72.829Elevated white blood cell count, unspecified
    E29.1Testicular hypofunction
    K65.9Peritonitis, unspecified
    N80.9Endometriosis, unspecified
    N84.0Polyp of corpus uteri

    Showing 1–10 of 27

    Related Payer Policy Updates

    Specialty: Genetic & Molecular Testing1 / 3

    10 rows

    PolicyPayerEffective Date
    Oral Cancer Screening and TestingOscar Health2027-01-01
    RTM Testing for Alpha-1 Antitrypsin DeficiencyOscar Health2027-01-01
    Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policybcbsvermont2027-01-01
    Carrier Testing Panels for Genetic Diseases (for Kentucky Only)UnitedHealthcare2026-10-01
    Genetic Testing for Neurological Disorders (for Kansas Only)UnitedHealthcare2026-10-01
    Genetic and Molecular TestingProvidence Health Plan2026-10-01
    Cell-Free Fetal DNA Testing (for Idaho Only)UnitedHealthcare2026-10-01
    Next Generation Sequencing for Minimal Residual Disease DetectionProvidence Health Plan2026-10-01
    Pharmacogenetic Panel Testing (for Kansas Only)UnitedHealthcare2026-10-01
    Non-Covered Genetic Panel TestsProvidence Health Plan2026-10-01

    Related Codes

    CPT-81490-RA-DISEASE-ACTIVITY-SCORE-SERUM-BIOMARKER-PANEL

    CPT 81490: Serum Biomarker Panel and RA Disease Activity Score

    CPT-81493-CORONARY-ARTERY-DISEASE-23-GENE-RT-PCR-RISK-SCORE

    CPT 81493: 23-Gene RT-PCR Molecular Test With CAD Risk Score

    CPT-81503-ALGORITHMIC-LAB-RISK-SCORE-CA125-APOLIPOPROTEIN-A1

    CPT 81503: Algorithmic Risk Score from Multiple Lab Markers

    CPT-81504-TUMOR-ORIGIN-RNA-EXPRESSION-CLASSIFIER

    CPT 81504: Tumor RNA Expression Profile Comparison

    CPT-81506-DIABETES-BIOMARKER-PANEL-WITH-RISK-SCORE

    CPT 81506: Diabetes Risk Score from Biochemical Assays

    CPT-81507-NIPS-CELL-FREE-DNA-TRISOMY-RISK-ANALYSIS

    CPT 81507: Noninvasive Prenatal Testing for Trisomies 13, 18, 21

    CPT-81508-PAPP-A-HCG-ALGORITHMIC-RISK-ASSAY

    CPT 81508: First-Trimester PAPP-A and hCG Risk Score

    CPT-81509-LAB-ALGORITHMIC-RISK-ASSESSMENT-PAPP-A-HCG-DIA

    CPT 81509: Prenatal Biochemical Risk Score from PAPP–A, hCG, DIA

    CPT-81510-PRENATAL-TRIPLE-MARKER-ALGORITHMIC-RISK-ASSESSMENT

    CPT 81510: Prenatal Serum Screening with Algorithmic Risk Score

    CPT-81511-MULTIANALYTE-SERUM-SCREENING-ALGORITHMIC-RISK-SCORE

    CPT 81511: Maternal Serum Quadruple Marker Risk Score

    Showing 1–10 of 41

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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