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    v1.0.30
    OpenPayerBilling CodesMultianalyte Assays with Algorithmic AnalysesCPT cpt-81510-prenatal-triple-marker-algorithmic-risk-assessment
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    CPT 81510: Prenatal Serum Screening with Algorithmic Risk Score

    CPT code 81510 describes a laboratory service in which the lab performs technical assays for three analytes—AFP, uE3, and hCG—and applies an algorithmic analysis combining those test results with patient data to generate a patient risk score; service type: algorithmic prenatal serum screening using multi-analyte test results; typical site of service: clinical laboratory or reference diagnostic laboratory performing prenatal screening.

    For related coverage guidance, see recent payer policy updates: Oral Cancer Screening and Testing, RTM Testing for Alpha-1 Antitrypsin Deficiency, Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policy.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient scenario involves a pregnant patient undergoing second‑trimester aneuploidy risk assessment. The ordering obstetric provider (obstetrician-gynecologist or maternal-fetal medicine specialist) collects a maternal serum sample and submits clinical data (maternal age, gestational age, weight, diabetes status, race/ethnicity, and prior obstetric history) with the specimen. The laboratory performs quantitative immunoassays for alpha-fetoprotein (AFP), unconjugated estriol (uE3), and human chorionic gonadotropin (hCG), and then runs a validated algorithm that integrates the three analyte values with the patient data to generate a computed patient risk score for neural tube defects and chromosomal abnormalities (e.g., trisomy 21, trisomy 18). The lab analyst documents the technical testing, performs quality control, and reports the risk score and interpretation to the ordering provider via the laboratory information system. Typical site of service is an outpatient clinical laboratory or hospital clinical laboratory with specimen collection in an outpatient clinic, prenatal clinic, or physician office collection area. The service type is a laboratory algorithmic risk assessment based on assay results and patient data, representing the technical component of a multi-analyte biochemical screening test.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    81025Urinalysis; non-automated, with microscopyPerformed in prenatal visits to evaluate maternal health prior to or alongside serum screening
    36415Collection of venous blood by venipunctureSpecimen collection required before laboratory measurement of AFP, uE3, hCG and algorithmic risk analysis
    82040Albumin; urine, quantitativeAncillary prenatal laboratory that may be ordered in the same panel of prenatal labs
    86705Rubella antibody, IgGPrenatal serologies commonly ordered during the same prenatal visit as serum screening
    G0101Cervical cancer screening; collection of specimen for cyto or HPVPreventive services frequently coordinated in prenatal care visits

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207Q00000X
    207L00000X
    207K00000X
    207LP2900X
    3336C0002X
    261QS1000X
    208200000X
    156F00000X

    Related ICD-10-CM Codes

    19 rows

    ICD-10-CM CodeDescription
    O09.10Supervision of pregnancy with history of ectopic pregnancy, unspecified trimester
    O09.30Supervision of pregnancy with insufficient antenatal care, unspecified trimester
    O09.611Supervision of young primigravida, first trimester
    O09.612Supervision of young primigravida, second trimester
    O28.1Abnormal biochemical finding on antenatal screening of mother
    O28.3Abnormal ultrasonic finding on antenatal screening of mother
    O35.2XX0Maternal care for (suspected) hereditary disease in fetus, not applicable or unspecified
    O35.2XX1Maternal care for (suspected) hereditary disease in fetus, fetus 1
    O36.4XX0Maternal care for intrauterine death, not applicable or unspecified
    O36.4XX1Maternal care for intrauterine death, fetus 1

    Showing 1–10 of 19

    Related Payer Policy Updates

    Specialty: Genetic & Molecular Testing1 / 3

    10 rows

    PolicyPayerEffective Date
    Oral Cancer Screening and TestingOscar Health2027-01-01
    RTM Testing for Alpha-1 Antitrypsin DeficiencyOscar Health2027-01-01
    Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policybcbsvermont2027-01-01
    Carrier Testing Panels for Genetic Diseases (for Kentucky Only)UnitedHealthcare2026-10-01
    Genetic Testing for Neurological Disorders (for Kansas Only)UnitedHealthcare2026-10-01
    Genetic and Molecular TestingProvidence Health Plan2026-10-01
    Cell-Free Fetal DNA Testing (for Idaho Only)UnitedHealthcare2026-10-01
    Next Generation Sequencing for Minimal Residual Disease DetectionProvidence Health Plan2026-10-01
    Pharmacogenetic Panel Testing (for Kansas Only)UnitedHealthcare2026-10-01
    Non-Covered Genetic Panel TestsProvidence Health Plan2026-10-01

    Related Codes

    CPT-81490-RA-DISEASE-ACTIVITY-SCORE-SERUM-BIOMARKER-PANEL

    CPT 81490: Serum Biomarker Panel and RA Disease Activity Score

    CPT-81493-CORONARY-ARTERY-DISEASE-23-GENE-RT-PCR-RISK-SCORE

    CPT 81493: 23-Gene RT-PCR Molecular Test With CAD Risk Score

    CPT-81500-CA125-HE4-ALGORITHMIC-RISK-SCORE

    CPT 81500: Algorithmic Risk Score Using CA-125 and HE4

    CPT-81503-ALGORITHMIC-LAB-RISK-SCORE-CA125-APOLIPOPROTEIN-A1

    CPT 81503: Algorithmic Risk Score from Multiple Lab Markers

    CPT-81504-TUMOR-ORIGIN-RNA-EXPRESSION-CLASSIFIER

    CPT 81504: Tumor RNA Expression Profile Comparison

    CPT-81506-DIABETES-BIOMARKER-PANEL-WITH-RISK-SCORE

    CPT 81506: Diabetes Risk Score from Biochemical Assays

    CPT-81507-NIPS-CELL-FREE-DNA-TRISOMY-RISK-ANALYSIS

    CPT 81507: Noninvasive Prenatal Testing for Trisomies 13, 18, 21

    CPT-81508-PAPP-A-HCG-ALGORITHMIC-RISK-ASSAY

    CPT 81508: First-Trimester PAPP-A and hCG Risk Score

    CPT-81509-LAB-ALGORITHMIC-RISK-ASSESSMENT-PAPP-A-HCG-DIA

    CPT 81509: Prenatal Biochemical Risk Score from PAPP–A, hCG, DIA

    CPT-81511-MULTIANALYTE-SERUM-SCREENING-ALGORITHMIC-RISK-SCORE

    CPT 81511: Maternal Serum Quadruple Marker Risk Score

    Showing 1–10 of 41

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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