CPT 81360: ZRSR2 Mutation Analysis, Blood Specimen

CPT code 81360 describes a laboratory technical service that detects common alterations in the ZRSR2 gene (for example, E65fs, E122fs, R448fs) from a specimen such as blood; this molecular diagnostic test is performed by a lab analyst and provides results used in the diagnosis and prognosis of hematologic disorders including various leukemias, typically performed as a molecular pathology / genetic testing service in clinical laboratories or hospital pathology departments.

Customize your policy alerts

Sign up for cpt 81360 policy alerts

Get alerted when payer policies referencing 81360 are released or updated.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Explore openpayer tools

View all tools

CPT 81360: ZRSR2 Mutation Analysis, Blood Specimen

Customize your policy alerts

Sign up for cpt 81360 policy alerts

Get alerted when payer policies referencing 81360 are released or updated.

Monitor payer policy activity

Receive email alerts as soon as relevant payer policies are published or updated.

Clinical & Coding Specifications

Clinical Context

A 62-year-old patient with progressive cytopenias and abnormal peripheral blood smear is evaluated for a suspected myeloid neoplasm. The hematologist orders targeted molecular testing for the ZRSR2 gene to detect frameshift variants (for example E65fs, E122fs, R448fs) that can inform diagnosis, prognosis, and therapeutic decisions in myelodysplastic syndromes and certain leukemias. A clinic or hospital phlebotomy team collects a peripheral blood sample (or bone marrow aspirate when indicated) and sends the specimen to a clinical molecular diagnostics laboratory. The laboratory analyst performs 81360 using validated molecular methods (next-generation sequencing, targeted panel, or fragment analysis) to detect common sequence alterations in ZRSR2. The lab issues a report noting detected variants, their allele frequencies, and interpreted clinical significance. Results are routed to the ordering hematologist/oncologist for incorporation into the diagnostic impression and care plan. Typical sites of service include outpatient hospital laboratories, independent clinical molecular laboratories, and hospital inpatient laboratories. Typical personnel involved include the ordering hematologist/oncologist, phlebotomist, laboratory technician/analyst, molecular pathologist, and reporting clinician.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`0000U`	Molecular pathology procedure, not elsewhere classified, specific assay — example assay for mutation detection	Some laboratories perform custom or proprietary assays in addition to standard molecular tests for comprehensive genomic profiling; may be ordered when broader or proprietary testing is needed.
`81211`	BCR-ABL1; detection by quantitative RT-PCR or other methods	Frequently ordered in the diagnostic workup of myeloid neoplasms alongside targeted gene panels; informs diagnosis and therapy in leukemia.
`81445`	Oncology (somatic) multigene panel sequencing, 5-50 genes	Often performed concurrently or prior to single-gene tests to provide broader mutation profiling in hematologic malignancies.
`0002M`	Molecular pathology procedure, interpretation and report	Laboratories may bill separate interpretation components when complex bioinformatic or consultative interpretation is required.
`88184`	Flow cytometry, cell surface or intracellular analysis, 1-2 markers	Performed in parallel to molecular testing to immunophenotype hematologic cells and support diagnosis.

Related Modifiers

6 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
90	Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…	- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
91	Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…	- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
22	Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…	- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207RH0000X	Hematology (Internal Medicine) Physician	An internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
2080P0207X	Pediatric Hematology & Oncology Physician	A pediatrician trained in the combination of pediatrics, hematology and oncology to recognize and manage pediatric blood disorders and cancerous disea…
2084P0800X	Psychiatry Physician	A Psychiatrist specializes in the prevention, diagnosis, and treatment of mental disorders, emotional disorders, psychotic disorders, mood disorders, …
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
2084P0804X	Child & Adolescent Psychiatry Physician	Child & Adolescent Psychiatry is a subspecialty of psychiatry with additional skills and training in the diagnosis and treatment of developmental, beh…
2080P0208X	Pediatric Infectious Diseases Physician	A pediatrician trained to care for children in the diagnosis, treatment and prevention of infectious diseases. This specialist can apply specific know…
261QM1100X	Military/U.S. Coast Guard Outpatient Clinic/Center	The Defense Health Program or U.S. Coast Guard funded "fixed" facilities or distinct parts of a facility, providing outpatient medical and dental serv…
207RP1002X	Physician Nutrition Specialist (Internal Medicine)	A physician who specializes in the diagnosis and treatment of primary nutritional diseases (e.g., undernutrition, overnutrition, and genetic or acquir…

CPT 81105: HPA-1 (ITGB3/CD61) Genotyping, Technical Component

CPT-81106-HPA-2-T145M-GENETIC-ALLELE-ANALYSIS

CPT 81106: HPA-2 (T145M) Platelet Antigen Genotyping

CPT-81107-HPA-3-GENETIC-ANALYSIS-TECHNICAL-COMPONENT

CPT 81107: HPA‑3 (I843S) Platelet Antigen Genotyping

CPT-81108-HPA-4-R143Q-GENOTYPING

CPT 81108: HPA-4 (R143Q) Genotyping

CPT-81109-HPA-5-K505E-GENETIC-ANALYSIS

CPT 81109: HPA-5 (K505E) Genotyping Test

CPT-81110-HPA-6-R489Q-GENOTYPING

CPT 81110: HPA-6 (R489Q) Genotyping, Technical Component

CPT-81111-HPA-9-V837M-ALLELE-ANALYSIS

CPT 81111: HPA-9 (V837M) Genotyping, Technical Test

CPT-81112-HPA-15-GENETIC-ANALYSIS-S682Y

CPT 81112: HPA-15 (S682Y) Platelet Antigen Genotyping

CPT-81120-IDH1-MOLECULAR-DIAGNOSTIC-TEST

CPT 81120: IDH1 Mutation Detection, Technical Component

CPT-81121-IDH2-MOLECULAR-DIAGNOSTIC-TEST

CPT 81121: IDH2 Mutation Detection, Technical Component

Showing 1–10 of 199

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

Explore openpayer tools

View all tools

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`0000U`	Molecular pathology procedure, not elsewhere classified, specific assay — example assay for mutation detection	Some laboratories perform custom or proprietary assays in addition to standard molecular tests for comprehensive genomic profiling; may be ordered when broader or proprietary testing is needed.
`81211`	BCR-ABL1; detection by quantitative RT-PCR or other methods	Frequently ordered in the diagnostic workup of myeloid neoplasms alongside targeted gene panels; informs diagnosis and therapy in leukemia.
`81445`	Oncology (somatic) multigene panel sequencing, 5-50 genes	Often performed concurrently or prior to single-gene tests to provide broader mutation profiling in hematologic malignancies.
`0002M`	Molecular pathology procedure, interpretation and report	Laboratories may bill separate interpretation components when complex bioinformatic or consultative interpretation is required.
`88184`	Flow cytometry, cell surface or intracellular analysis, 1-2 markers	Performed in parallel to molecular testing to immunophenotype hematologic cells and support diagnosis.

Related Modifiers

6 rows

Modifier	Description	When to Use
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
90	Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…	- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
91	Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…	- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
22	Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…	- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207RH0000X	Hematology (Internal Medicine) Physician	An internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
2080P0207X	Pediatric Hematology & Oncology Physician	A pediatrician trained in the combination of pediatrics, hematology and oncology to recognize and manage pediatric blood disorders and cancerous disea…
2084P0800X	Psychiatry Physician	A Psychiatrist specializes in the prevention, diagnosis, and treatment of mental disorders, emotional disorders, psychotic disorders, mood disorders, …
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
2084P0804X	Child & Adolescent Psychiatry Physician	Child & Adolescent Psychiatry is a subspecialty of psychiatry with additional skills and training in the diagnosis and treatment of developmental, beh…
2080P0208X	Pediatric Infectious Diseases Physician	A pediatrician trained to care for children in the diagnosis, treatment and prevention of infectious diseases. This specialist can apply specific know…
261QM1100X	Military/U.S. Coast Guard Outpatient Clinic/Center	The Defense Health Program or U.S. Coast Guard funded "fixed" facilities or distinct parts of a facility, providing outpatient medical and dental serv…
207RP1002X	Physician Nutrition Specialist (Internal Medicine)	A physician who specializes in the diagnosis and treatment of primary nutritional diseases (e.g., undernutrition, overnutrition, and genetic or acquir…

CPT 81105: HPA-1 (ITGB3/CD61) Genotyping, Technical Component

CPT-81106-HPA-2-T145M-GENETIC-ALLELE-ANALYSIS

CPT 81106: HPA-2 (T145M) Platelet Antigen Genotyping

CPT-81107-HPA-3-GENETIC-ANALYSIS-TECHNICAL-COMPONENT

CPT 81107: HPA‑3 (I843S) Platelet Antigen Genotyping

CPT-81108-HPA-4-R143Q-GENOTYPING

CPT 81108: HPA-4 (R143Q) Genotyping

CPT-81109-HPA-5-K505E-GENETIC-ANALYSIS

CPT 81109: HPA-5 (K505E) Genotyping Test

CPT-81110-HPA-6-R489Q-GENOTYPING

CPT 81110: HPA-6 (R489Q) Genotyping, Technical Component

CPT-81111-HPA-9-V837M-ALLELE-ANALYSIS

CPT 81111: HPA-9 (V837M) Genotyping, Technical Test

CPT-81112-HPA-15-GENETIC-ANALYSIS-S682Y

CPT 81112: HPA-15 (S682Y) Platelet Antigen Genotyping

CPT-81120-IDH1-MOLECULAR-DIAGNOSTIC-TEST

CPT 81120: IDH1 Mutation Detection, Technical Component

CPT-81121-IDH2-MOLECULAR-DIAGNOSTIC-TEST

CPT 81121: IDH2 Mutation Detection, Technical Component

Showing 1–10 of 199

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

CPT 81360: ZRSR2 Mutation Analysis, Blood Specimen

Sign up for cpt 81360 policy alerts

OpenPayer

CPT 81360: ZRSR2 Mutation Analysis, Blood Specimen

Sign up for cpt 81360 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

References