CPT code 81349 describes a laboratory test using low–pass whole genome sequencing (WGS) performed with high-throughput next-generation sequencing to evaluate the entire genome for copy-number variants (CNVs) and extended regions of homozygosity that can be associated with developmental delay or other genetic conditions; the service is a molecular/genomic diagnostic assay typically performed as a technical laboratory procedure in a clinical genomics or reference laboratory (laboratory/remote processing site) rather than in an outpatient clinic or inpatient bedside setting.