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    v1.0.31
    OpenPayerBilling CodesGenetic Analysis ProceduresCPT cpt-81193-ntrk3-translocation-testing-ffpe-tissue
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    CPT 81193: NTRK3 Translocation Analysis from FFPE Tissue

    CPT code 81193 describes a laboratory molecular pathology assay in which the technical component analyzes NTRK3 (neurotrophic receptor tyrosine kinase 3) translocations from a specimen such as formalin-fixed paraffin-embedded tissue (FFPE); service type: molecular pathology / genetic translocation testing; typical site of service: clinical molecular diagnostics laboratory performing technical processing and analysis of tumor tissue for TRK-mediated oncogenic fusions in solid tumors (for example congenital/infantile fibrosarcoma).

    For related coverage guidance, see recent payer policy updates: Minimal Residual Disease (MRD) Testing for Cancer, Biomarker Testing Mandate, Prenatal (Fetal) Diagnostic Testing.

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    Clinical & Coding Specifications

    Clinical Context

    A pediatric patient aged 2 months presents with a rapidly growing soft-tissue mass on the extremity. Imaging suggests a congenital/infantile soft-tissue tumor. A core needle biopsy is performed and submitted as formalin-fixed paraffin-embedded tissue (FFPE) to the pathology laboratory. The lab performs histology and immunohistochemistry; based on morphology and clinical suspicion for TRK-driven neoplasia, the lab orders molecular testing for NTRK3 gene rearrangements. The laboratory technologist extracts nucleic acid from the FFPE specimen and runs a validated molecular assay (RNA-based next-generation sequencing or a validated targeted fusion assay) to detect NTRK3 translocations. Results are interpreted by a molecular pathologist and reported in the pathology report, documenting presence or absence of NTRK3 fusions to guide potential targeted therapy decisions and clinical management. Typical site of service is an outpatient or hospital-based pathology/molecular diagnostics laboratory that receives FFPE tissue from ambulatory surgical centers, hospital operating rooms, or interventional radiology suites.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    88305Level IV surgical pathology, gross and microscopic examinationInitial histologic evaluation of the FFPE tissue that often precedes selection of molecular testing such as NTRK3 fusion analysis.
    81162KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) gene analysis; targeted sequence analysisExample of another single-gene molecular test frequently ordered in tumor workups; listed to show similar molecular testing workflow.
    81479Unlisted molecular pathology procedureUsed when a specific molecular assay does not have an assigned CPT; may be used in complex or novel fusion assays if applicable.
    0000UProprietary/lab-developed test ID (example placeholder)Some laboratories use specific LDT CPT Category I codes (also represented by proprietary codes) for validated NTRK3 fusion assays; these are used when a specific code exists.
    88342Immunohistochemistry, each antibody (including controls), per specimen; single antibody stainIHC for pan-TRK or other markers frequently performed prior to or alongside molecular NTRK3 testing as a screening step.

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    90Modifier ‑90 (Reference/Outside Laboratory) indicates that a laboratory test was performed by an entity other than the treating or reporting provider. The American Medical Association defines…- Use CPT modifier -90 when a laboratory test is performed by an outside/reference laboratory (an entity other than the treating or reporting physician or qualified professional) and the claim needs…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RH0000X
    208000000X
    207P00000X
    363L00000X
    207YX0905X
    251X00000X
    333300000X
    246QC1000X

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    C16.9Malignant neoplasm of stomach, unspecified
    C18.9Malignant neoplasm of colon, unspecified
    C22.9Malignant neoplasm of liver, not specified as primary or secondary
    C25.9Malignant neoplasm of pancreas, unspecified
    C34.90Malignant neoplasm of unspecified part of unspecified bronchus or lung
    C41.9Malignant neoplasm of bone and articular cartilage, unspecified
    C49.9Malignant neoplasm of connective and soft tissue, unspecified
    C49.A1Gastrointestinal stromal tumor of esophagus
    C50.911Malignant neoplasm of unspecified site of right female breast
    C56.9Malignant neoplasm of unspecified ovary

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Genetic & Molecular Testing1 / 3

    10 rows

    PolicyPayerEffective Date
    Minimal Residual Disease (MRD) Testing for Cancerregence2027-01-01
    Biomarker Testing MandateBlue Cross Blue Shield - Rhode Island2027-01-01
    Prenatal (Fetal) Diagnostic TestingBlue Cross Blue Shield - Rhode Island2027-01-01
    Oral Cancer Screening and TestingOscar Health2027-01-01
    RTM Testing for Alpha-1 Antitrypsin DeficiencyOscar Health2027-01-01
    Cytochrome P450 Genotype-Guided Treatment Strategy Corporate Medical Policybcbsvermont2027-01-01
    Cytochrome P450 Genotypingblue cross blue shield - tennessee2026-12-31
    Polygenic Risk ScoreBlue Cross Blue Shield - Rhode Island2026-12-01
    Gene Expression Profiling for Cutaneous MelanomaBlue Cross Blue Shield - Rhode Island2026-12-01
    Genetic Testing for Macular Degenerationregence2026-11-01

    Related Codes

    CPT-81105-HPA-1-PLATELET-ANTIGEN-1-GENOTYPING-ITGB3-CD61

    CPT 81105: HPA-1 (ITGB3/CD61) Genotyping, Technical Component

    CPT-81106-HPA-2-T145M-GENETIC-ALLELE-ANALYSIS

    CPT 81106: HPA-2 (T145M) Platelet Antigen Genotyping

    CPT-81107-HPA-3-GENETIC-ANALYSIS-TECHNICAL-COMPONENT

    CPT 81107: HPA‑3 (I843S) Platelet Antigen Genotyping

    CPT-81108-HPA-4-R143Q-GENOTYPING

    CPT 81108: HPA-4 (R143Q) Genotyping

    CPT-81109-HPA-5-K505E-GENETIC-ANALYSIS

    CPT 81109: HPA-5 (K505E) Genotyping Test

    CPT-81110-HPA-6-R489Q-GENOTYPING

    CPT 81110: HPA-6 (R489Q) Genotyping, Technical Component

    CPT-81111-HPA-9-V837M-ALLELE-ANALYSIS

    CPT 81111: HPA-9 (V837M) Genotyping, Technical Test

    CPT-81112-HPA-15-GENETIC-ANALYSIS-S682Y

    CPT 81112: HPA-15 (S682Y) Platelet Antigen Genotyping

    CPT-81120-IDH1-MOLECULAR-DIAGNOSTIC-TEST

    CPT 81120: IDH1 Mutation Detection, Technical Component

    CPT-81121-IDH2-MOLECULAR-DIAGNOSTIC-TEST

    CPT 81121: IDH2 Mutation Detection, Technical Component

    Showing 1–10 of 199

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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