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    OpenPayerBilling CodesDiagnostic Radiology (Diagnostic Imaging) Procedures of the HeartCPT cpt-75580-ffr-ct-from-ccta-augmentation-software-report
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    CPT 75580: CTA-Derived Coronary Fractional Flow Reserve Estimation

    Medicare pays $619 on average nationally for this procedure.

    CPT code 75580 describes augmentative software analysis of a separate coronary computed tomography angiography (CTA) dataset to estimate coronary fractional flow reserve (FFR), with a physician or qualified healthcare professional providing interpretation and a written report; service type: image-based physiologic derivation of coronary FFR using CTA data; typical site of service: outpatient imaging center or hospital radiology/cardiology imaging department.

    For related coverage guidance, see recent payer policy updates: Automated Ambulatory Blood Pressure Monitoring for Diagnosis of Hypertension in Patients with Elevated Office Blood Pressure, Cardiology - Ivabradine, Cardiac Computed Tomography (CCT)/Coronary Computed Tomographic Angiography (CCTA).

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 58-year-old with stable exertional angina and intermediate coronary artery disease risk who previously underwent a coronary computed tomography angiography (CCTA) that demonstrated 40–70% stenosis in one or more coronary segments. The clinician orders augmentative software analysis to derive noninvasive fractional flow reserve from the existing CCTA dataset. A cardiovascular imaging technologist or PACS specialist exports the deidentified CCTA DICOM images to the FDA-cleared software. The software performs computational fluid dynamics and lesion-specific FFRCT estimation. A board-certified cardiologist or cardiovascular radiologist reviews the software output, integrates the FFRCT values with the anatomic CCTA findings, documents a formal interpretation, and issues an electronic report that supports clinical decision-making for medical therapy versus invasive coronary angiography.

    Common workflow steps:

    • Order and verify indication for 75580 based on prior CCTA demonstrating intermediate stenosis.

    • Retrieve and prepare CCTA DICOM images for transfer to the FFRCT software vendor.

    • Run the augmentative software analysis and receive quantitative FFRCT values by coronary segment.

    • Interpreting physician reviews images and FFRCT results, produces an interpretation and final report.

    • Bill 75580 for the software-based analysis with the physician interpretation; append appropriate modifier(s) per payer and service circumstances.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    75574Coronary computed tomography angiography, with contrast, including image post-processing when performed; single study without cardiac CTA flow analysisThis is the anatomic CCTA acquisition typically performed before FFRCT analysis; 75580 analyzes data derived from a prior CCTA such as 75574.
    93799Unlisted cardiovascular service or procedureMay be used for ancillary or nonstandard processing services if vendor-specific technical services are not separately billable; not routine for FFRCT.
    71046Radiologic examination, chest, two views, frontal and lateralMay be performed as adjunct baseline imaging but is not a substitute for CCTA when planning FFRCT.
    93000Electrocardiogram, routine ECG with at least 12 leads; with interpretation and reportOften performed as part of pre-test assessment or outpatient evaluation prior to CCTA and FFRCT.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207T00000X
    2084P0800X
    367A00000X
    261QA0005X
    207RS0012X
    2472D0500X
    101YS0200X
    342000000X

    Related Payer Policy Updates

    Specialty: Cardiology1 / 3

    10 rows

    PolicyPayerEffective Date
    Automated Ambulatory Blood Pressure Monitoring for Diagnosis of Hypertension in Patients with Elevated Office Blood PressureBluecross Idaho2026-11-01
    Cardiology - IvabradineCigna2026-10-15
    Cardiac Computed Tomography (CCT)/Coronary Computed Tomographic Angiography (CCTA)univerahealthcare2026-10-15
    Percutaneous Ventricular Assist DeviceUnitedHealthcare2026-10-01
    Cardiovascular Disease Risk AssessmentOscar Health2026-10-01
    Biomarkers for Myocardial Infarction and Chronic Heart FailureOscar Health2026-10-01
    Multiple Procedure Payment Reduction for Diagnostic Cardiovascular ProceduresBlue Cross Blue Shield - Maine2026-10-01
    Left Atrial Appendage Closure Devicesexcellus_health_plan_inc2026-09-17
    Left Atrial Appendage Closure Devicesuniverahealthcare2026-09-17
    Cardiac Omnibus CodesCigna2026-09-15

    Related Codes

    CPT-75557-CARDIAC-MRI-NON-CONTRAST-STRUCTURE-AND-FUNCTION

    CPT 75557: Cardiac MRI Morphology and Function, No Contrast

    CPT-75559-CARDIAC-MRI-STRESS-NON-CONTRAST

    CPT 75559: Cardiac MRI with Stress, Non-Contrast

    CPT-75561-CARDIAC-MRI-WITH-AND-WITHOUT-CONTRAST

    CPT 75561: Cardiac MRI, Non-Contrast Followed by Contrast

    CPT-75563-CARDIAC-MRI-STRESS-REST-WITH-AND-WITHOUT-CONTRAST

    CPT 75563: Cardiac MRI Stress Study, With and Without Contrast

    CPT-75565-CARDIAC-MRI-VELOCITY-FLOW-MAPPING

    CPT 75565: Cardiac MRI with Velocity (Flow) Mapping

    CPT-75571-CORONARY-CALCIUM-SCORING-CT-NON-CONTRAST

    CPT 75571: Coronary Artery Calcium Scoring by Non-Contrast CT

    CPT-75572-CARDIAC-CT-3D-POST-PROCESSING-FUNCTIONAL-ASSESSMENT

    CPT 75572: Cardiac CT with 3D Post-Processing and Function Assessment

    CPT-75573-CARDIAC-CT-CONGENITAL-HEART-EVALUATION

    CPT 75573: Cardiac CT for Congenital Heart Anomaly Evaluation

    CPT-75574-CARDIAC-CT-WITH-CONTRAST-CORONARY-EVALUATION

    CPT 75574: Contrast-Enhanced Cardiac CT Angiography

    CPT-75577-CORONARY-CTA-PLAQUE-QUANTIFICATION-POST-PROCESSING

    CPT 75577: Coronary CTA Plaque Quantification and Report

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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    0074UComputed tomography, heart, noninvasive FFRCT analysis (proprietary/Category III when applicable)Some workflows include proprietary or category-level codes for vendor-specific FFRCT processing; relates directly as an alternative or adjunct to 75580.