CPT code 64415 denotes injection(s) of anesthetic and/or steroid into the brachial plexus for regional anesthesia or therapeutic nerve blockade of the upper extremity. This procedure is clinically important for perioperative pain control, chronic pain management, and diagnostic nerve blockade. Nationally, accurate coding of 64415 affects procedural reporting, payment determination, and quality tracking for nerve block services. Key public and commercial payers covered in this summary include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise framing of the clinical procedure and site-of-service considerations, an outline of common billing modifiers used with nerve block services, and an overview of payer coverage patterns and coding guidance where available. The publication also highlights typical settings where the service is delivered and practical coding notes that influence claims adjudication. Data not available in the input will be explicitly noted in relevant sections. The content is intended to help coding managers, billing staff, and policy analysts understand the clinical context and payer landscape for CPT code 64415 at a national level.