CPT code 64405 denotes an injection of an anesthetic and/or steroid into the greater occipital nerve and is commonly used in the management of occipital neuralgia and posterior scalp pain. Nationally, this procedural code matters because it represents a frequently billed interventional pain service performed in outpatient settings and influences clinical pathways for headache and neuropathic pain management. Key payers in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare.

Readers will learn what CPT code 64405 represents clinically and operationally, how it is typically delivered (nerve block in outpatient clinics, ambulatory surgery centers, or physician offices), and which major payers cover or adjudicate claims for this service. The publication provides benchmarks for utilization and reimbursement (where available), summaries of relevant policy considerations and documentation expectations, and clinical context around indications and typical procedural settings. Data not available in the input will be clearly noted. The focus is national in scope and intended for billing managers, clinicians involved in pain procedures, and policy analysts tracking interventional pain services.