CPT code 64408 denotes injection of an anesthetic, steroid, or both into the tenth cranial nerve (vagus nerve). This targeted nerve injection is used for diagnostic or therapeutic purposes and can be reported for one or more injections performed during a single procedure. Nationally, services involving cranial nerve blocks are clinically significant due to procedural complexity, need for image guidance or specialist skill, and variable coverage policies across major payers.

Key payers covered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise explanation of the clinical context and service settings for 64408, a summary of payer coverage considerations and common modifiers reported with the service, and benchmarks and policy updates relevant to billing and reimbursement. The publication highlights coding guidance for reporting the procedure when multiple injections occur during a single session and outlines areas where payers commonly require documentation, such as indication, procedural technique, and expected outcomes.

This overview is aimed at clinicians, billing professionals, and policy analysts seeking a national perspective on clinical use, payer handling, and administrative considerations for CPT code 64408.