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    v1.0.30
    OpenPayerBilling CodesUreter and Pelvis Transurethral Surgical ProceduresCPT cpt-52327-cystourethroscopy-subureteral-implant-injection-for-vur
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    CPT 52327: Cystourethroscopy with Ureteral Submucosal Injection

    Medicare pays $228 on average nationally for this procedure.

    CPT code 52327 describes cystourethroscopy with injection of implant material beneath a ureteral orifice (endoscopic ureteral bulking) to prevent vesicoureteral reflux; this procedure is an endoscopic operative urinary tract intervention typically performed in an operating room or procedure suite and the service includes cystoscopic inspection of the bladder, urethra, prostatic urethra, and ureteric orifices with catheterization of the ureteral opening for implant delivery.

    For related coverage guidance, see recent payer policy updates: Dental Anesthesia Services, Anesthesia Services for Interventional Pain Management Procedures in an Adult, General Anesthesia and Conscious Sedation Services.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a pediatric or adult patient with symptomatic or recurrent urinary tract infections, suspected or confirmed vesicoureteral reflux (VUR), or persistent urinary incontinence after conservative management. The patient presents to an outpatient or ambulatory surgery center for evaluation and treatment. Pre-procedure workflow includes history and physical, urinalysis and culture, renal bladder ultrasound or voiding cystourethrogram confirming VUR, informed consent, and anesthesia evaluation. In the operating room or procedure suite under general anesthesia (common in children) or monitored anesthesia care/local with sedation (common in adults), the provider performs cystourethroscopy using a cystoscope passed through the urethra into the bladder to inspect the urethra, bladder mucosa, and ureteral orifices. The clinician cannulates the ureteral orifice with a catheter tip and injects a bulking/implant material submucosally beneath the ureteral opening to create a coaptation that reduces retrograde urine flow. Post-procedure workflow includes recovery, monitoring for hematuria or urinary retention, discharge instructions, and scheduling of follow-up imaging (often a voiding cystourethrogram) to assess reflux resolution. Typical site of service: outpatient hospital procedural suite, ambulatory surgery center, or operating room. Service type: endoscopic surgical procedure (cystourethroscopy with ureteral orifice injection/implant).

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    52000Cystourethroscopy, diagnostic; with or without collection of specimen(s) by brushing or washingDiagnostic cystoscopy often performed prior to injection to inspect bladder and ureteral orifices
    52005Cystourethroscopy, with ureteroscopy and/or pyeloscopy, with or without collection of specimen(s)Performed when ureteral or intrarenal inspection beyond the orifice is required
    51702Complex urethral catheterization, requiring cystoscopy; with insertion of indwelling ureteral stentMay be performed if ureteral stenting is required for drainage or during management of complication
    51701Complex urethral catheterization, requiring cystoscopy, with collection of urine from catheterized bladderRelated catheter management often performed in conjunction
    52085Cystourethroscopy with ureteral catheterization, with or without irrigation, instillation, or ureteropyelographyUreteral catheterization or imaging adjuncts commonly used to localize or cannulate the orifice

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    63Modifier‑63 is appended to surgical CPT codes (20000–69990) when a procedure is performed on a neonate or infant weighing ≤ 4 kg (about 8.8 lbs). The AMA/AAPC definition specifies this use and notes…- Use modifier -63 only for surgical procedures in the CPT 20000–69990 series performed on a neonate or infant who weighs ≤ 4 kg at the time of the procedure; it indicates increased complexity due to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207L00000X
    208D00000X
    367A00000X
    364SP0813X
    261QG0250X
    1744R1103X
    332000000X
    2086S0102X

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    N11.0Nonobstructive reflux-associated chronic pyelonephritis
    N13.6Pyonephrosis
    N13.70Vesicoureteral-reflux, unspecified
    N13.71Vesicoureteral-reflux without reflux nephropathy
    N13.8Other obstructive and reflux uropathy
    N20.0Calculus of kidney
    N20.1Calculus of ureter
    N28.89Other specified disorders of kidney and ureter
    N30.00Acute cystitis without hematuria
    N30.01Acute cystitis with hematuria

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Anesthesiology1 / 3

    10 rows

    PolicyPayerEffective Date
    Dental Anesthesia ServicesProvidence Health Plan2026-10-01
    Anesthesia Services for Interventional Pain Management Procedures in an AdultCigna2026-09-15
    General Anesthesia and Conscious Sedation ServicesUnitedHealthcare2026-09-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Elective Inpatient Services (for Idaho Only)UnitedHealthcare2026-06-01
    Sites of Servicepriority health2026-06-01
    Coverage for Ambulatory Surgery Unit (ASU)/Outpatient Facility and Anesthesia for Dental Servicesuniverahealthcare2026-05-21

    Related Codes

    CPT-52320-CYSTOURETHROSCOPY-URETERAL-STONE-REMOVAL

    CPT 52320: Cystourethroscopy with Ureteral Stone Removal

    CPT-52325-URETERAL-LITHOTRIPSY-CYSTOURETHROSCOPY

    CPT 52325: Cystourethroscopy with Ureteral Stone Fragmentation and Removal

    CPT-52330-CYSTOURETHROSCOPY-URETERAL-STONE-MANIPULATION

    CPT 52330: Cystourethroscopy with Ureteral Stone Manipulation

    CPT-52332-CYSTOURETHROSCOPY-URETERAL-STENT-PLACEMENT

    CPT 52332: Cystourethroscopy with Ureteral Stent Placement

    CPT-52334-CYSTOURETHROSCOPY-PERCUTANEOUS-RETROGRADE-NEPHROSTOMY

    CPT 52334: Cystourethroscopy with Guidewire for Retrograde Nephrostomy

    CPT-52341-CYSTOURETHROSCOPY-URETERAL-STRICTURE-TREATMENT

    CPT 52341: Cystourethroscopy with Ureteral Stricture Treatment

    CPT-52342-CYSTOURETHROSCOPY-WITH-URETERAL-CATHETER-TO-UPJ-FOR-UPJ-STRICTURE-TREATMENT

    CPT 52342: Cystourethroscopy with Ureteral Catheterization and UPJ Stricture Treatment

    CPT-52343-CYSTOURETHROSCOPY-WITH-INTRARENAL-STRICTURE-TREATMENT

    CPT 52343: Cystourethroscopy with Intrarenal Stricture Treatment

    CPT-52344-CYSTOURETHROSCOPY-URETERAL-STRICTURE-TREATMENT-URETEROSCOPY

    CPT 52344: Cystourethroscopy with Ureteral Stricture Treatment and Ureteroscopy

    CPT-52345-CYSTOURETHROSCOPY-URETEROSCOPIC-TREATMENT-UPJ-STRICTURE

    CPT 52345: Cystourethroscopy with Ureteroscopic UPJ Stricture Treatment

    Showing 1–10 of 17

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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